STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Evolution & Discovery · Source-indexed research

A chronology of PWWP research

Follow the papers, experimental structures, and curated ligand records behind the Atlas.

Discovery 1.0.0
97PWWP research publication events
230experimental PDB entries
128searchable literature records
29citations without a recorded year
Each date keeps its meaning.

Publication entries use the year recorded in the bibliography. PDB deposition and initial release use their separate recorded dates. These events do not establish discovery priority. Verification scope is shown for every source; an undated deposition citation is retained in the literature index.

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Research scope omits supporting methodology citations. Select “All source citations” or use the full literature index to include them.

Recorded research events

97 events

2026

Publication year

High-Affinity Nanobody Against the LEDGF PWWP Domain Inhibits Chromatin Binding In Vitro.

Biomolecules · Vantieghem T; Jansen S; Akele TZ; et al.

PWWP nanobody binding; binder-alone crystal structures are not PWWP structures

Experimental research

Curated ligand / preparation records

NbH10named macromolecule no full sequence identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:42194065

Publication year

NSD2 degradation remediates the oncogenic cistrome in t(4;14) multiple myeloma.

Blood · Hu, B.; Edwards, J.T.; Modi, H.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9Y60:primary

Publication year

Structure and function of IWS1 in transcription elongation.

Nucleic Acids Res. · Syau, D.; Steinruecke, F.; Roth, S.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9XYC:primary

Publication year

Computational analysis of non-synonymous SNPs-induced structural perturbations and histone binding alterations in the PWWP domain of PWWP2A and PWWP2B proteins.

Journal of biomolecular structure & dynamics · M S; N S; Oviya IR; et al.

Published computational variant study; computational rather than experimental evidence

Computational study

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:42444282

Publication year

Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.

Proc.Natl.Acad.Sci.USA · Chen, J.; Lu, J.; Long, Z.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:11NZ:primary

Publication year

Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin.

Nat.Struct.Mol.Biol. · Yan, Y.; Zhou, X.E.; Thomas, S.L.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9MP0:primary

Publication year

Core nucleosomes are refractory to lentiviral DNA integration.

Nat Commun · Hope, J.; Punch, E.; Cook, N.J.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9S28:primary

Publication year

Structural basis of NSD2 degradation via targeted recruitment of SCF-FBXO22.

Nat Commun · Robertson, K.C.; Amann, S.J.; Liu, T.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:29HG:primary

Publication year

Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease.

Nature communications · Lu J; Vig E; Chen J; et al.

Hierarchical DNMT3A autoinhibition; review coordinate-level PWWP coverage

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:41708613

Publication year

Molecular basis for the inhibition of de novo DNA methylation by TCL1A.

Nat Commun · Liu, Q.; Li, J.; Wang, X.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9LQ1:primary

Publication year

AI-Driven Discovery of a Hydrophobic-Tag Degrader Targeting NSD3 for Lung Squamous Carcinoma Therapy.

Journal of medicinal chemistry · Xiu SY; Jia ZY; Li Q; et al.

Published AI-driven NSD3 degrader discovery

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:42503659

Publication year

Fluorogenic Ligand Enables Identification of NSD3-Overexpressed Tumors by Targeting the PWWP1 Domain of NSD3.

Analytical chemistry · Li Y; Shao S; Lei Q; et al.

NSD3 PWWP1-targeting fluorogenic ligand

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:41820229

Publication year

Nucleosome spacing regulates linker methylation by DNMT3A2/3B3.

Molecular cell · Xie X; Liu M; Chua GNL; et al.

Nucleosome spacing and linker methylation structural context

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:41742418

Publication year

Discovery and biological evaluation of HS13 as a novel covalent ligand targeting the NSD2-PWWP1 domain.

Bioorganic & medicinal chemistry · Liu C; Wang Q; Xie X; et al.

HS13 covalent NSD2 PWWP1 ligand

Experimental research

Curated ligand / preparation records

HS13paper label exact identity unresolved

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:42442058

Publication year

De novo design of proteinaceous binders targeting the LEDGF PWWP domain.

Protein science : a publication of the Protein Society · Vantieghem T; Delepine J; Noppen S; et al.

Designed JUBO protein binders and LEDGF PWWP complex

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary abstract and data availability verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:42489162

2025

Publication year

Histone modification-driven structural remodeling unleashes DNMT3B in DNA methylation.

Science advances · Cho CC; Huang HH; Jiang BC; et al.

Histone-driven DNMT3B structural remodeling and DNA methylation

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:40138405

Publication year

Crystal engineering of the hepatoma-derived growth factor-related protein 2 PWWP domain towards crystallographic fragment screening.

Acta crystallographica. Section F, Structural biology communications · Vantieghem T; Osipov EM; Beelen S; et al.

HRP2 PWWP C64S crystallization engineering and lattice comparison

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:40709919

Publication year

Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain.

Communications biology · Jin Z; Meng Z; Liu Y; et al.

Drosophila P75 PWWP thymidine-rich DNA recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:40089621

Publication year

Structural and Molecular Insight into the PWWP1 Domain of NSD2 from the Discovery of Novel Binders Via DNA-Encoded Library Screening.

ACS medicinal chemistry letters · Collie GW; Ackroyd B; Corbishley C; et al.

NSD2 PWWP1 DEL binders, extended construct, and engineered crystal systems

Experimental research

Curated ligand / preparation records

UNC6934exact single CCD identity
compound 11 (Collie 2025)assayed stereoisomeric mixture not single chemical identity
compound 12 (Collie 2025)paper label exact identity unresolved
compound 13 (Collie 2025)paper label exact identity unresolved
compound 5 (Collie 2025)assayed stereoisomeric mixture not single chemical identity
compound 6 (Collie 2025)paper label exact identity unresolved
compound 7 (Collie 2025)exact single CCD identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:40959233

Publication year

Fragment-Based Screening of NSD2-PWWP1 Identifies Novel Covalent Allosteric Ligands That Diminish Methyllysine and DNA Binding Abilities of NSD2.

J.Med.Chem. · Huang, Y.; Li, Y.; Chen, X.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9KN9:primary

2024

Publication year

The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.

Embo Rep. · Wapenaar, H.; Clifford, G.; Rolls, W.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:8QZM:primary

Publication year

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.

J.Med.Chem. · Carlino, L.; Astles, P.C.; Ackroyd, B.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:9EXW:primary

Publication year

Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader.

Journal of medicinal chemistry · Liu L; Parolia A; Liu Y; et al.

LLC0424 NSD2 PROTAC

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:38687638

Publication year

Inhibitors targeting the PWWP domain-containing proteins.

European journal of medicinal chemistry · Huang Y; Li B; Wu Z; et al.

PWWP inhibitor discovery review for citation chaining only

Review / synthesis

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:39413441

Publication year

Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.

European journal of medicinal chemistry · Vantieghem T; Aslam NA; Osipov EM; et al.

68-fragment HRP-family crystallographic screen and rational fragment expansion

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:39461037

Publication year

Fragment-based discovery of small molecule inhibitors of the HDGFRP2 PWWP domain.

FEBS letters · Wei X; Li S; Li Z; et al.

Varenicline and BPP fragment ligands of HDGFL2 PWWP

Experimental research

Curated ligand / preparation records

BPPexact single CCD identity
vareniclineexact single CCD identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:39031937

2023

Publication year

Structural basis for the allosteric regulation and dynamic assembly of DNMT3B.

Nucleic Acids Res. · Lu, J.; Fang, J.; Zhu, H.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:8EIH:primary

Publication year

Multivalency of nucleosome recognition by LEDGF.

Nucleic acids research · Koutná E; Lux V; Kouba T; et al.

Multivalent LEDGF nucleosome recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:37615563

Publication year

Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding.

Nucleic Acids Res. · Bruekner, S.R.; Pieters, W.; Fish, A.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:8AG6:primary

Publication year

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

Journal of the American Chemical Society · Hanley RP; Nie DY; Tabor JR; et al.

NSD2 degrader targeting H3K36me2 reduction

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:36976643

2022

Publication year

H3K36 methylation and DNA-binding both promote Ioc4 recruitment and Isw1b remodeler function.

Nucleic Acids Res. · Li, J.; Bergmann, L.; Rafael de Almeida, A.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:7E29:primary

Publication year

A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.

Nature chemical biology · Dilworth D; Hanley RP; Ferreira de Freitas R; et al.

UNC6934 chemical probe and UNC7145 negative control

Experimental research

Curated ligand / preparation records

MRT866exact single CCD identity
UNC6934exact single CCD identity
UNC7145paper label exact identity unresolved

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:34782742

Publication year

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos.

Journal of medicinal chemistry · Meng F; Xu C; Park KS; et al.

NSD2 and Ikaros/Aiolos degrader development

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:35895319

Publication year

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors.

Journal of medicinal chemistry · Li N; Yang H; Liu K; et al.

Structure-based NSD2 PWWP1 inhibitor series

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:35704853

Publication year

Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

European journal of medicinal chemistry · Sun Y; Zhang Y; Chen X; et al.

NSD3-targeted PROTAC development; literature-only future-work context

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:35717870

2021

Publication year

Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.

Nature · Li, W.; Tian, W.; Yuan, G.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:7CRO:primary

Publication year

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures.

Nat Commun · Barski, M.S.; Vanzo, T.; Zhao, X.Z.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:7OUF:primary

Publication year

Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2.

Journal of medicinal chemistry · Ferreira de Freitas R; Liu Y; Szewczyk MM; et al.

MRT837 and NSD2 PWWP1 small-molecule antagonists

Experimental research

Curated ligand / preparation records

MR837 (3f)exact single CCD identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:33522809

Publication year

Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1.

Journal of molecular biology · Gong W; Liang Q; Tong Y; et al.

Experimental solution structure of engineered tandem PWWP–ARID; PDB 6L87

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:34506790

Publication year

Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.

Biochemical and biophysical research communications · Zhang M; Yang Y; Zhou M; et al.

NSD-family PWWP histone and DNA-binding comparison

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:34271259

Publication year

Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.

Biochimica et biophysica acta. Gene regulatory mechanisms · Zhang M; Lei M; Qin S; et al.

BRPF2 PWWP-DNA crystal structure

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:33556623

2020

Publication year

Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding.

Nature structural & molecular biology · Wang H; Farnung L; Dienemann C; et al.

PWWP-nucleosome cryo-EM structure and cross-gyre DNA binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:31819277

Publication year

Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.

Nature · Xu TH; Liu M; Zhou XE; et al.

DNMT3A2-DNMT3B3-nucleosome cryo-EM context; PWWP coordinate inclusion must be checked

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:32968275

Publication year

Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.

Nat Commun · Barski, M.S.; Minnell, J.J.; Hodakova, Z.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:7PEL:primary

2019

Publication year

Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and a H3K36me2-containing histone peptide

Nucleic Acids Res. · Wang, Z.; Tian, W.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:6IIT:primary

Publication year

Complex structure of the HRP3 PWWP domain with both a 16-bp TA-rich DNA and an H3K36me3-containing histone peptide

Nucleic Acids Res. · Wang, Z.; Tian, W.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:6IIS:primary

Publication year

Complex structure of the HRP3 PWWP domain with a 10-bp GC-rich DNA

Nucleic Acids Res. · Wang, Z.; Tian, W.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:6IIR:primary

Publication year

Complex structure of the HRP3 PWWP domain with a 16-bp TA-rich DNA

Nucleic Acids Res. · Wang, Z.; Tian, W.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:6IIQ:primary

Publication year

Apo-form structure of the HRP3 PWWP domain

Nucleic Acids Res. · Wang, Z.; Tian, W.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:6IIP:primary

Publication year

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.

Science advances · LeRoy G; Oksuz O; Descostes N; et al.

LEDGF and HDGF2 nucleosome-dependent transcription

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:31616795

Publication year

The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin.

Nucleic acids research · Tian W; Yan P; Xu N; et al.

HRP3 PWWP recognition of DNA minor groove

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:31162607

Publication year

Solution structure of TbTFIIS2-2 PWWP domain from Trypanosoma brucei and its binding to H4K17me3 and H3K32me3.

The Biochemical journal · Wang R; Gao J; Zhang J; et al.

Trypanosoma PWWP solution structure and methylhistone binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:30626613

Publication year

Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.

Nature chemical biology · Böttcher J; Dilworth D; Reiser U; et al.

BI-9321 PWWP1 chemical probe and fragment-to-probe development

Experimental research

Curated ligand / preparation records

BI-9321exact single CCD identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary data availability and developer assays verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:31285596

Publication year

H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction.

Journal of molecular biology · Dukatz M; Holzer K; Choudalakis M; et al.

DNA and H3K36me2/3 contributions to DNMT3A PWWP chromatin interaction

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:31634469

Publication year

Resonance assignments for the tandem PWWP-ARID domains of human RBBP1.

Biomolecular NMR assignments · Gong W; Yao X; Liang Q; et al.

NMR resonance assignments of human RBBP1 tandem PWWP-ARID; assignment report distinguished from structure determination

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:30666492

2018

Publication year

Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor.

Scientific reports · Chen LY; Huang YC; Huang ST; et al.

HDGF domain swapping and SMYD1 interaction

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:29321480

Publication year

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

Nature communications · Link S; Spitzer RMM; Sana M; et al.

PWWP2A chromatin contacts and MTA1-specific NuRD; modeled PWWP structure is not experimental

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:30327463

Publication year

A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

Nature communications · Zhang T; Wei G; Millard CJ; et al.

PWWP2A/B variant NuRD complexes at active genes

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:30228260

2017

Publication year

Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

The EMBO journal · Pünzeler S; Link S; Wagner G; et al.

PWWP2A multivalent H2A.Z nucleosome binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:28645917

Publication year

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

Structure (London, England : 1993) · Yao N; Li J; Liu H; et al.

ZMYND8-drebrin structural interaction

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:28966017

2016

Publication year

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.

The Journal of biological chemistry · Sankaran SM; Wilkinson AW; Elias JE; et al.

NSD2 PWWP recognition of H3K36me2 and chromatin recruitment

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:26912663

Publication year

Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8.

The Journal of biological chemistry · Adhikary S; Sanyal S; Basu M; et al.

Combinatorial histone recognition by ZMYND8

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:26655721

Publication year

ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes

Mol.Cell · Li, N.; Li, Y.; Lv, J.; et al.

Citation accompanying an included PWWP-domain deposition

Deposition-linked bibliography

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: PDB citation metadata; original paper not independently reviewed unless curated record is linked

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

REF:PDB:5B73:primary

Publication year

Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B.

Journal of structural biology · Rondelet G; Dal Maso T; Willems L; et al.

DNMT3B PWWP-H3K36me3 crystal structures and nucleosome recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:26993463

Publication year

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.

Cell reports · Savitsky P; Krojer T; Fujisawa T; et al.

PHD-BRD-PWWP cassette multivalent histone and DNA engagement

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:27926874

Publication year

PWWP domains and their modes of sensing DNA and histone methylated lysines.

Biophysical reviews · Rona GB; Eleutherio ECA; Pinheiro AS

PWWP DNA and methyllysine recognition review

Review / synthesis

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:28510146

Publication year

Solution structure of TbTFIIS2-1 PWWP domain from Trypanosoma brucei.

Proteins · Wang R; Zhang J; Liao S; et al.

Trypanosoma brucei PWWP solution structure

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:27005948

2015

Publication year

The First Residue of the PWWP Motif Modulates HATH Domain Binding, Stability, and Protein-Protein Interaction.

Biochemistry · Hung YL; Lee HJ; Jiang I; et al.

PWWP motif first-residue contribution to HATH binding and stability

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:26067205

2014

Publication year

A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.

Molecular & cellular proteomics : MCP · Gilbert TM; McDaniel SL; Byrum SD; et al.

Yeast PWWP targeting of NuA3 to H3K36me3

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:25104842

Publication year

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.

Nature · Wen H; Li Y; Xi Y; et al.

Histone variant H3.3K36me3 recognition and tumor suppression

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:24590075

Publication year

Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding.

Cell research · Wang J; Qin S; Li F; et al.

BS69 Bromo-ZnF-PWWP structure and nucleosome recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:24675531

Publication year

Structure and function of the nucleosome-binding PWWP domain.

Trends in biochemical sciences · Qin S; Min J

Nucleosome-binding PWWP domain review

Review / synthesis

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:25277115

Publication year

BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.

Molecular cell · Guo R; Zheng L; Park JW; et al.

Histone H3.3 recognition coupled to pre-mRNA processing

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:25263594

2013

Publication year

TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.

PloS one · Morchikh M; Naughtin M; Di Nunzio F; et al.

TOX4 and NOVA1 as LEDGF PWWP interaction partners

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:24312278

Publication year

Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.

Epigenetics & chromatin · van Nuland R; van Schaik FM; Simonis M; et al.

Nucleosomal DNA contribution to PSIP1 PWWP recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:23656834

Publication year

Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.

Nucleic acids research · Eidahl JO; Crowe BL; North JA; et al.

LEDGF PWWP solution structure and cooperative nucleosome recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:23396443

Publication year

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα.

Cell · Li F; Mao G; Tong D; et al.

H3K36me3 recognition and human mismatch repair

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:23622243

2012

Publication year

Evolution of the PWWP-domain encoding genes in the plant and animal lineages.

BMC evolutionary biology · Alvarez-Venegas R; Avramova Z

Comparative evolution of PWWP-domain genes in animal and plant lineages

Comparative sequence research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:22734652

Publication year

Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.

The Journal of biological chemistry · Gong W; Zhou T; Mo J; et al.

Royal-family domain comparison in ARID4A; chromobarrel coordinate 2LCC is not a PWWP structure

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary abstract and structural metadata verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:22247551

Publication year

Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.

The Biochemical journal · Qiu Y; Zhang W; Zhao C; et al.

Pdp1 PWWP solution structure and H4K20/DNA binding sites

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:22150589

2011

Publication year

Structural and histone binding ability characterizations of human PWWP domains.

PloS one · Wu H; Zeng H; Lam R; et al.

Family-wide human PWWP structure and histone binding comparison

Experimental research

Curated ligand / preparation records

Bis-Trisexact single CCD identity
H4K20me3 peptide / trimethyllysine monomerdefined modified peptide sequence not monomer identity

Preparations retain their measured assays and identity qualifications. A structure link does not transfer activity to a modeled chemical component.

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: primary full text sections verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:21720545

2010

Publication year

The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.

The Journal of biological chemistry · Dhayalan A; Rajavelu A; Rathert P; et al.

DNMT3A PWWP reading of H3K36me3

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:20547484

Publication year

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1.

Nature structural & molecular biology · Vezzoli A; Bonadies N; Allen MD; et al.

BRPF1 PWWP H3K36me3 molecular recognition

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:20400950

Publication year

Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.

Molecular cell · Huen MS; Huang J; Leung JW; et al.

EXPAND1/MUM1 PWWP chromatin architecture and DNA damage response

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:20347427

2009

Publication year

Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.

Molecular cell · Wang Y; Reddy B; Thompson J; et al.

Pdp1 PWWP control of Set9-dependent H4K20 methylation

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:19250904

2008

Publication year

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

Journal of virology · Shun MC; Botbol Y; Li X; et al.

LEDGF PWWP residues in chromatin binding and HIV infectivity

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:18799576

Publication year

Human mismatch repair protein MSH6 contains a PWWP domain that targets double stranded DNA.

Biochemistry · Laguri C; Duband-Goulet I; Friedrich N; et al.

Experimental characterization of MSH6 PWWP as a dsDNA-binding module

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:18484749

2007

Publication year

Hepatoma-derived growth factor binds DNA through the N-terminal PWWP domain.

BMC molecular biology · Yang J; Everett AD

HDGF PWWP-mediated DNA binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: full text retrieved metadata verified claims pending

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:17974029

Publication year

PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.

Journal of molecular biology · Sue SC; Lee WT; Tien SC; et al.

Domain-swapped HDGF PWWP dimer and heparin binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:17270212

2006

Publication year

High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.

Protein science : a publication of the Protein Society · Lukasik SM; Cierpicki T; Borloz M; et al.

High-resolution HDGF PWWP crystal structure

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:16384999

2005

Publication year

Solution structure of the PWWP domain of the hepatoma-derived growth factor family.

Protein science : a publication of the Protein Society · Nameki N; Tochio N; Koshiba S; et al.

HRP-3 PWWP solution structure

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:15689505

2004

Publication year

The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin.

Molecular and cellular biology · Chen T; Tsujimoto N; Li E

PWWP-directed pericentric heterochromatin methylation

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:15456878

Publication year

Chromatin targeting of de novo DNA methyltransferases by the PWWP domain.

The Journal of biological chemistry · Ge YZ; Pu MT; Gowher H; et al.

PWWP-dependent chromatin targeting of de novo DNA methyltransferases

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:14998998

Publication year

Solution structure and heparin interaction of human hepatoma-derived growth factor.

Journal of molecular biology · Sue SC; Chen JY; Lee SC; et al.

HDGF solution structure and heparin interaction

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:15491618

2003

Publication year

Structural variation in PWWP domains.

Journal of molecular biology · Slater LM; Allen MD; Bycroft M

Fission-yeast PWWP solution structure and structural variation

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:12842472

2002

Publication year

The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds.

Nature structural biology · Qiu C; Sawada K; Zhang X; et al.

Foundational mammalian DNMT3B PWWP fold and DNA binding

Experimental research

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:11836534

2000

Publication year

The PWWP domain: a potential protein-protein interaction domain in nuclear proteins influencing differentiation?

FEBS letters · Stec I; Nagl SB; van Ommen GJ; et al.

Original PWWP family definition and comparative sequence discovery

Family sequence analysis / review

Source verification and date precision

Publication year recorded in the frozen bibliography; no month or day inferred.

Verification scope: bibliographic metadata and abstract verified

Display scope follows the frozen bibliography record; no new functional milestone is inferred.

PMID:10802047

Traceable data · Versioned separately

Sources and scope

The original v1.2 bibliography and experimental deposition records supply this index. Search operates over the complete record set, including DOI, PDB, protein, title, and curated ligand names. The literature index also retains undated citations.

Scientific limitations
  • Bibliographic metadata and selected full-text verification have different scopes, shown per source. This is not a systematic literature review.
  • The chronology indexes recorded dates; it does not assign discovery priority or infer milestones from citation order.
  • The Phenix methods citation is retained as methodological context, excluded from the default research timeline, and available in the full literature index and all-source scope.
  • Publication dates have year precision in the frozen bibliography. The year is not presented as 1 January.
  • PDB entries can be associated with a protein without observed PWWP coordinates; observed-coordinate status is explicit.
  • Current UniProt features are accepted only when the canonical sequence exactly matches the frozen Atlas sequence. Annotation evidence is not necessarily experimental evidence.
  • Mapped construct bars represent source-supported canonical segments, not inferred complete construct termini or complete folded-domain boundaries.
  • Isoform rows reuse source-validated PWWP core correspondence; other-domain architectures are not inferred for isoforms.
  • Ligand names are linked only through curated assay/preparation records. Structural occupancy, preparation identity, and activity remain separate.
  • Missing annotations, contacts, dates, or ligand links indicate missing curation in this snapshot, not biological absence.