Experimental structure
29HG
Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088
Original coordinates
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| NSD2 | B | ["B"] | UP:O96028:PWWP1 | 65 / 65 | 0 |
| NSD2 | B | ["B"] | UP:O96028:PWWP2 | 0 / 63 | 0 |
Chemical identity
Chemical components and interpretation
| CCD | Name | Role | Full InChIKey |
|---|---|---|---|
| A1J20 | ~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide | experimentally studied degrader functional | DEWAWAOVHSEUOF-UHFFFAOYSA-N |
Geometry, with defined scope
Independent contact evidence
Inspect 2 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| A1J20 · F | NSD2 · B | native annotation core contact | 2.71 / 2.71 |
| A1J20 · F | NSD2 · B | noncore contact in multidomain chain | — / — |
Biological partners
F-box only protein 22 · protein/peptide · label chains ["A"]
S-phase kinase-associated protein 1 · protein/peptide · label chains ["C"]
Cullin-1 · protein/peptide · label chains ["D"]
E3 ubiquitin-protein ligase RBX1 · protein/peptide · label chains ["E"]
Source interpretation
Focused scientific audit
This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.