PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

An atlas of PWWP-domain evidence

Explore the structures.
Follow the evidence.

A connected view of PWWP proteins, experimental structures, AlphaFold predictions and published chemical evidence—with the source and scientific context behind every record.

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From the coordinate archiveExperimental core
NSD2 PWWP1 experimental annotation-core Cα trace Static orthographic projection of PDB 9FOC chain A, derived from the unchanged representative crop. Guides connect consecutive canonical positions within 4.5 Å; these are not all-atom covalent bonds.
NSD2 · PWWP1

PDB 9FOC · Chain A · Cα annotation-core trace

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Explore an exampleNSD2NSD3LEDGFHDGFL2
30human protein records
33human domain annotations
18human domains with observed coordinates
206PDB entries with PWWP coordinates, across species

Full snapshot totals. The 230 protein-associated experimental entries include 24 without observed PWWP-core coordinates.

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One resource. Connected questions.

PWWP family

Find native domains, annotation tiers and experimental coverage.

Explore 42 annotation cores →

Experimental structures

Browse domain coverage and open deposited structure records.

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Core comparisons

Inspect aligned Cα models and recorded residue correspondence.

Explore 153 human pairs →

Chemical evidence

Trace chemical identities to preparations, assays and sources.

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Protein directory

30 records · human scope

27 human records have source-supported PWWP annotations; KDM3A, KDM3B and JMJD1C remain a separate predicted PWWP-like tier. Annotation support does not establish experimental function. PWWP4 retains an uncertain protein-existence flag.

Browse all 30 protein records in the selected scope
ProteinAccessionOrganismDomainsObserved PDB entriesAssignment
ARID4AP29374Homo sapiens13annotation supported
ARID4BQ4LE39Homo sapiens10annotation supported
BRD1O95696Homo sapiens13annotation supported
BRPF1P55201Homo sapiens17annotation supported
BRPF3Q9ULD4Homo sapiens11annotation supported
DNMT3AQ9Y6K1Homo sapiens114annotation supported
DNMT3BQ9UBC3Homo sapiens114annotation supported
GLYR1Q49A26Homo sapiens10annotation supported
HDGFP51858Homo sapiens12annotation supported
HDGFL1Q5TGJ6Homo sapiens10annotation supported
HDGFL2Q7Z4V5Homo sapiens186annotation supported
HDGFL3Q9Y3E1Homo sapiens15annotation supported
JMJD1CQ15652Homo sapiens10predicted PWWP like
KDM3AQ9Y4C1Homo sapiens10predicted PWWP like
KDM3BQ7LBC6Homo sapiens10predicted PWWP like
MBD5Q9P267Homo sapiens10annotation supported
MSH6P52701Homo sapiens12annotation supported
NSD1Q96L73Homo sapiens20annotation supported
NSD2O96028Homo sapiens219annotation supported
NSD3Q9BZ95Homo sapiens213annotation supported
PSIP1O75475Homo sapiens113annotation supported
PWWP2AQ96N64Homo sapiens10annotation supported
PWWP2BQ6NUJ5Homo sapiens11annotation supported
PWWP3AQ2TAK8Homo sapiens11annotation supported
PWWP3BQ5H9M0Homo sapiens10annotation supported
PWWP4A0A494C071Homo sapiens10annotation supported
Uncertain protein existence
ZCWPW1Q9H0M4Homo sapiens10annotation supported
ZCWPW2Q504Y3Homo sapiens10annotation supported
ZMYND11Q15326Homo sapiens11annotation supported
ZMYND8Q9ULU4Homo sapiens15annotation supported

Read each kind of evidence in context.

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01 / OBSERVED

Experimental coordinates

Domain mapping identifies observed residues. A protein-associated PDB entry need not contain the PWWP core.

02 / PREDICTED

Models and confidence

AlphaFold confidence describes a prediction. It does not establish protein existence, function or experimental observation.

03 / MEASURED

Assays and preparations

Measurements stay attached to the reported preparation and construct, with uncertainty and source scope visible.