Protein record

ARID4A

AT-rich interactive domain-containing protein 4A

P29374 at UniProt

Homo sapiens1257 amino acidsannotation supported

1annotated core in ARID4A

3PDB entries with observed PWWP1 coordinates

3model records for PWWP1

0frozen v1.2 assay / association records for PWWP1

Canonical sequence · Source-mapped regions

Protein domain architecture

1257 residues

PWWP annotation cores, other annotated regions, and deposited construct mappings share the canonical amino acid axis. The original Atlas PWWP intervals retain their source definitions.

PWWP annotation coreOther source annotationPredicted candidate, when present

2 additional source-supported regions · coordinates and evidence

UniProt feature coordinates accepted after exact canonical sequence identity check against the frozen Atlas. Source annotations can be inferred by sequence or curated from experiments; evidence codes remain attached. Other domain types link to their UniProt source because the Atlas records PWWP domains.

Source feature	Type	Amino acids	Evidence
ARID	Domain	309–401	ECO:0000255 PROSITE-ProRule: PRU00355
Tudor-knot	Domain	576–628	ECO:0000255

Deposited construct mapping

3 selected examples

Colored segments map deposited polymer sequences to this canonical protein; dark segments have observed coordinates. Unmapped tags and engineered residues are not assigned canonical positions. These are not certified whole-fold boundaries.

7V8Nchain A169–417

Mapping and construct evidence

Deposited polymer length: 253 residues. Mapped sequence identity: 100.0%. sequence differences or tags detected; biological versus engineered origin requires review.

PWWP1: 93 / 93 annotation-core Cα residues observed.

Frozen SIFTS aligned regions with construct-to-UniProt sequence comparison. Bars are mapped canonical segments; tags, insertions, and unmapped termini are not assigned canonical positions. PDB source.

Unmapped construct positions: 1–4.

2YRVchain A170–273

Mapping and construct evidence

Deposited polymer length: 117 residues. Mapped sequence identity: 100.0%. sequence differences or tags detected; biological versus engineered origin requires review.

PWWP1: 93 / 93 annotation-core Cα residues observed.

Unmapped construct positions: 1–7, 112–117.

6L87chain A171–280, 304–414

Mapping and construct evidence

Deposited polymer length: 229 residues. Mapped sequence identity: 98.64%. sequence differences or tags detected; biological versus engineered origin requires review.

PWWP1: 92 / 93 annotation-core Cα residues observed.

Source-recorded sequence differences:

[
  {
    "construct": "K",
    "entity_position": 108,
    "reference": "D",
    "uniprot_position": 278
  },
  {
    "construct": "K",
    "entity_position": 110,
    "reference": "E",
    "uniprot_position": 280
  },
  {
    "construct": "K",
    "entity_position": 112,
    "reference": "E",
    "uniprot_position": 305
  }
]

Unmapped construct positions: 222–229.

One mapped example per native domain, preferring frozen experimental representatives; up to four distinct mapped intervals.

Validated isoform differences · 2 PWWP correspondence records

Only source-validated PWWP core correspondences from the frozen v1.2 isoform audit; other-domain architectures are not projected onto isoforms. Coordinates in the isoform column refer to the individual isoform sequence; deleted cores remain absent.

Isoform	Length	PWWP core	Source-mapped positions	Retention / source edits
P29374-2	1203	PWWP1	170–262 93 / 93 mapped residues; span may contain gaps	complete
P29374-3	1188	PWWP1	170–262 93 / 93 mapped residues; span may contain gaps	complete

Viewing ARID4A PWWP1

Canonical annotation interval 170–262 · pfam via InterPro API. annotation core; not a certified complete folded domain or pocket.

Alternative PWWP annotations and interval provenance

[
  {
    "end": 262,
    "identifier": "IPR012603",
    "integrated_identifier": null,
    "model": null,
    "name": "ARID4A/B, PWWP domain",
    "representative": false,
    "score": null,
    "source": "interpro",
    "source_url": "https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/P29374/?page_size=200",
    "start": 170
  },
  {
    "end": 262,
    "identifier": "PF08169",
    "integrated_identifier": "IPR012603",
    "model": "PF08169",
    "name": "RBB1NT (NUC162) domain",
    "representative": false,
    "score": 2.5e-33,
    "source": "pfam",
    "source_url": "https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/P29374/?page_size=200",
    "start": 170
  }
]

PWWP1 · source-classified Phase 6A evidence

Ligands & Bioactivity

Explore all domain compounds →

0 chemical or preparation profiles · 0 domain-attributed assay / association observations. Counts refer to the curated snapshot.

0 profiles

Deposited research ligands

No records in this category for the selected domain in the curated snapshot.

0 profiles

Studied without research structure

No records in this category for the selected domain in the curated snapshot.

0 profiles

Experiment-specific controls

No records in this category for the selected domain in the curated snapshot.

0 profiles

Ambiguous / indirect evidence

No records in this category for the selected domain in the curated snapshot.

Open this domain in Structural & Binding Landscape →

PWWP1 · Deposited coordinates

Experimental coverage and AlphaFold correspondence

3 entry / domain records

One representative chain per PDB entry and native domain. RMSD uses fixed UniProt correspondence and all common Cα atoms; it is reported only for ≥40 atoms and ≥80% core coverage. A value is descriptive, not a prediction benchmark.

PDB	Chain	Observed core Cα	Class	Method / resolution	AF RMSD Å	Review
2YRV	A	93 / 93	APO	SOLUTION NMR	1.98	No classification flag
7V8N	A	93 / 93	APO	X-RAY DIFFRACTION 2.05 Å	1.82	No classification flag
6L87	A	92 / 93	APO	SOLUTION NMR	3.81	No classification flag

PWWP1 · Measured preparations

Frozen v1.2 assay records

Explore evidence links

This retained table is the original source projection. The Phase 5 Ligands & Bioactivity section above includes added observations and reviewed target context. Values remain attached to their assay, construct and preparation. A crystal structure does not transfer affinity to another construct or stereoisomer. Assay pages preserve field-level source-verification states where reviewed; unreviewed null fields remain uncurated.

Preparation / identity	Assay and result	Construct	Evidence and source
No curated assay row for this domain. This does not establish that no literature evidence exists.

Scientific review queue

PWWP1 · Prediction evidence

Predicted models

3 model records

Domain retention uses independently reconstructed UniProt isoform edits. Local pLDDT is not experimental confirmation and does not establish interdomain orientation.

Model	Origin	Core retention	Core mean pLDDT	Full mean pLDDT
AF-P29374-F1:v6 Canonical	GDM	complete	86.6	56.3
AF-P29374-2-F1:v6	GDM	complete	86.8	56.7
AF-P29374-3-F1:v6	GDM	complete	86.8	57.2

PWWP1 · Structural correspondence

Human annotation-core comparisons

17 pairs

Structural alignment establishes a residue correspondence for these cropped cores. It does not establish equivalent ligand pockets, function or selectivity.

Domain pair	Aligned Cα	US-align RMSD Å	TM score A / B	View
ARID4A PWWP1 BRD1 PWWP1	59	2.16	0.501 / 0.543	Aligned core viewer
ARID4A PWWP1 BRPF1 PWWP1	59	1.94	0.521 / 0.567	Aligned core viewer
ARID4A PWWP1 BRPF3 PWWP1	59	1.83	0.526 / 0.572	Aligned core viewer
ARID4A PWWP1 DNMT3A PWWP1	59	1.84	0.539 / 0.787	Aligned core viewer
ARID4A PWWP1 DNMT3B PWWP1	59	1.72	0.544 / 0.795	Aligned core viewer
ARID4A PWWP1 HDGF PWWP1	57	2.68	0.469 / 0.67	Aligned core viewer
ARID4A PWWP1 HDGFL2 PWWP1	58	1.71	0.541 / 0.802	Aligned core viewer
ARID4A PWWP1 HDGFL3 PWWP1	57	1.97	0.51 / 0.745	Aligned core viewer
ARID4A PWWP1 MSH6 PWWP1	57	2.52	0.488 / 0.668	Aligned core viewer
ARID4A PWWP1 NSD2 PWWP1	55	2.16	0.493 / 0.664	Aligned core viewer
ARID4A PWWP1 NSD3 PWWP1	56	2.17	0.5 / 0.68	Aligned core viewer
ARID4A PWWP1 NSD3 PWWP2	59	1.91	0.533 / 0.736	Aligned core viewer
ARID4A PWWP1 PSIP1 PWWP1	60	2.42	0.504 / 0.67	Aligned core viewer
ARID4A PWWP1 PWWP2B PWWP1	52	2.34	0.459 / 0.653	Aligned core viewer
ARID4A PWWP1 PWWP3A PWWP1	55	2.92	0.438 / 0.596	Aligned core viewer
ARID4A PWWP1 ZMYND11 PWWP1	51	2.39	0.444 / 0.705	Aligned core viewer
ARID4A PWWP1 ZMYND8 PWWP1	51	2.22	0.447 / 0.72	Aligned core viewer