PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Experimental structure

8Z6C

Crystal structure of HDGFRP2 PWWP domain in complex with 4-(4-bromo-1H-pyrazol-3-yl) pyridine

Co-Crystals PWWP coordinates observed X-RAY DIFFRACTION

Original coordinates

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PDB deposition
8Z6C Deposited model
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.

Coordinate coverage

Mapped chains

3 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

ProteinLabel chainAuthor chainDomainObserved Cα / coreObserved substitutions
HDGFL2A["A"]UP:Q7Z4V5:PWWP158 / 580
HDGFL2B["B"]UP:Q7Z4V5:PWWP158 / 580
HDGFL2C["C"]UP:Q7Z4V5:PWWP158 / 580

Chemical identity

Chemical components and interpretation

3 component records
CCDNameRoleFull InChIKey
A1D734-(4-bromanyl-1~{H}-pyrazol-3-yl)pyridineexperimentally studied ligand
functional		LKKNQJJSEMQTHQ-UHFFFAOYSA-N
SO4SULFATE IONion/additive
incidental		QAOWNCQODCNURD-UHFFFAOYSA-L
HOHWATERsolvent
incidental		XLYOFNOQVPJJNP-UHFFFAOYSA-N

Geometry, with defined scope

Independent contact evidence

Inspect 11 retained contact records
CCD / instanceProtein chainContact classMinimum core / broader domain distance Å
A1D73 · DHDGFL2 · Anative annotation core contact2.49 / 2.49
A1D73 · GHDGFL2 · Bnative annotation core contact2.49 / 2.49
A1D73 · DHDGFL2 · Cnative annotation core contact4.81 / 2.98
A1D73 · JHDGFL2 · Cnative annotation core contact2.56 / 2.56
SO4 · EHDGFL2 · Abroader Pfam PWWP contact6.81 / 2.75
SO4 · FHDGFL2 · Anative annotation core contact3.08 / 3.08
SO4 · IHDGFL2 · Anative annotation core contact3 / 3
SO4 · HHDGFL2 · Bnative annotation core contact2.74 / 2.74
SO4 · IHDGFL2 · Bbroader Pfam PWWP contact6.17 / 2.64
SO4 · HHDGFL2 · Cnative annotation core contact4.32 / 4.32
SO4 · KHDGFL2 · Cbroader Pfam PWWP contact5.81 / 2.65

Biological partners

No curated macromolecular partner record.

Source interpretation

Focused scientific audit

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retain with stated interpretation/caveats. Co-crystal supported for A1D73; all three cores present but some side chains incomplete. Chemical binding interpretation belongs to primary study.