Experimental structure

9E0G

A focus of tetramer (2) of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome

Complexes PWWP coordinates observed ELECTRON MICROSCOPY

Original coordinates

Explore the structure

Your molecular view is ready

Load the deposited coordinates to rotate, zoom and inspect the structure.

Drag to rotate · scroll or pinch to zoom. Keyboard: focus the view, then use arrow keys to rotate, + / − to zoom, and Home to reset.

Original coordinates are available from a locally verified historical archive or the bundled source and load on request.

Coordinate coverage

Mapped chains

4 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

Protein	Label chain	Author chain	Domain	Observed Cα / core
DNMT3A	C	["W"]	UP:Q9Y6K1:PWWP1	0 / 59
DNMT3A	D	["K"]	UP:Q9Y6K1:PWWP1	59 / 59
DNMT3B	A	["L"]	UP:Q9UBC3:PWWP1	0 / 59
DNMT3B	B	["X"]	UP:Q9UBC3:PWWP1	0 / 59

Chemical identity

Chemical components and interpretation

2 component records

CCD	Name	Role	Full InChIKey
ZN	ZINC ION	ion/cofactor_requires_context incidental	PTFCDOFLOPIGGS-UHFFFAOYSA-N
SAH	S-ADENOSYL-L-HOMOCYSTEINE	biological cofactor functional	ZJUKTBDSGOFHSH-WFMPWKQPSA-N

Geometry, with defined scope

Independent contact evidence

Inspect 11 retained contact records

CCD / instance	Protein chain	Contact class	Minimum core / broader domain distance Å
SAH · K	DNMT3A · C	noncore contact in multidomain chain	— / —
SAH · O	DNMT3A · D	noncore contact in multidomain chain	52.7 / 42.1
ZN · E	DNMT3B · A	noncore contact in multidomain chain	— / —
ZN · F	DNMT3B · A	noncore contact in multidomain chain	— / —
ZN · G	DNMT3B · A	noncore contact in multidomain chain	— / —
ZN · H	DNMT3A · C	noncore contact in multidomain chain	— / —
ZN · I	DNMT3A · C	noncore contact in multidomain chain	— / —
ZN · J	DNMT3A · C	noncore contact in multidomain chain	— / —
ZN · L	DNMT3A · D	noncore contact in multidomain chain	41.2 / 34.7
ZN · M	DNMT3A · D	noncore contact in multidomain chain	31.9 / 24.2
ZN · N	DNMT3A · D	noncore contact in multidomain chain	31.9 / 22.7

Biological partners

Isoform 3 of DNA (cytosine-5)-methyltransferase 3B · protein/peptide · label chains ["A","B"]

DNA (cytosine-5)-methyltransferase 3A · protein/peptide · label chains ["C","D"]

Source interpretation

Focused scientific audit

Full review queue

retain with stated interpretation/caveats. Complex supported; same one-observed-PWWP limitation as 9E0F. Whole-complex association does not establish direct contact with the short PWWP core.