Experimental structure
9FOE
Crystal structure of the PWWP1 domain of NSD2 bound by compound 7.
Original coordinates
Explore the structure
Load the deposited coordinates to rotate, zoom and inspect the structure.
Drag to rotate · scroll or pinch to zoom. Keyboard: focus the view, then use arrow keys to rotate, + / − to zoom, and Home to reset.
Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| NSD2 | A | ["A"] | UP:O96028:PWWP1 | 58 / 65 | 1 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 1 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| A1IEF · B | NSD2 · A | native annotation core contact | 3.12 / 3.12 |
Biological partners
No curated macromolecular partner record.
Source interpretation
Focused scientific audit
retain with stated interpretation/caveats. Co-crystal supported, but core 253–258 and 286 are absent; source sequence also has K256A/K257A/E285A and four additional substitutions. Unsuitable as a complete wild-type pocket exemplar.