Experimental structure
9MP0
The cryo-EM structure of the human DNA methyltransferases DNMT3A2 and DNMT3L dodecamer
Original coordinates
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| DNMT3A | A | ["L"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | B | ["M"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | C | ["N"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | D | ["O"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | E | ["R"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | F | ["S"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | G | ["T"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | H | ["U"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 32 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| SAH · N | DNMT3A · A | noncore contact in multidomain chain | — / — |
| SAH · R | DNMT3A · B | noncore contact in multidomain chain | — / — |
| SAH · V | DNMT3A · C | noncore contact in multidomain chain | — / — |
| SAH · Z | DNMT3A · D | noncore contact in multidomain chain | — / — |
| SAH · DA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| SAH · HA | DNMT3A · F | noncore contact in multidomain chain | — / — |
| SAH · LA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| SAH · PA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · K | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · L | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · M | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · O | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · P | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · Q | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · S | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · T | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · U | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · W | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · X | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · Y | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · AA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · BA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · CA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · EA | DNMT3A · F | noncore contact in multidomain chain | — / — |
| ZN · FA | DNMT3A · F | noncore contact in multidomain chain | — / — |
| ZN · GA | DNMT3A · F | noncore contact in multidomain chain | — / — |
| ZN · IA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · JA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · KA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · MA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · NA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · OA | DNMT3A · H | noncore contact in multidomain chain | — / — |
Biological partners
DNA (cytosine-5)-methyltransferase 3-like · protein/peptide · label chains ["I","J"]
Source interpretation
Focused scientific audit
This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.