Experimental structure
8Z6O
Crystal structure of HDGFRP2 PWWP domain in complex with Varenicline
Original coordinates
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| HDGFL2 | A | ["A"] | UP:Q7Z4V5:PWWP1 | 58 / 58 | 0 |
| HDGFL2 | B | ["B"] | UP:Q7Z4V5:PWWP1 | 58 / 58 | 0 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 2 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| DMS · C | HDGFL2 · A | native annotation core contact | 3.02 / 3.02 |
| QMR · D | HDGFL2 · B | native annotation core contact | 2.81 / 2.81 |
Biological partners
No curated macromolecular partner record.
Source interpretation
Focused scientific audit
retain with stated interpretation/caveats. Co-crystal supported for varenicline/QMR; DMS is solvent. Protein-ligand geometry does not establish clinical or cellular relevance.