Experimental structure
9Q7U
Composite map for Cryo-EM structure of DNMT3A2-DNMT3B3 tetramer bound to 167H3K36me2-nucleosome
Original coordinates
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Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| DNMT3A | M | ["K"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | N | ["L"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3B | K | ["V"] | UP:Q9UBC3:PWWP1 | 0 / 59 | 0 |
| DNMT3B | L | ["Z"] | UP:Q9UBC3:PWWP1 | 0 / 59 | 0 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 11 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| SAO · U | DNMT3A · M | noncore contact in multidomain chain | 35 / 24.4 |
| SAO · Y | DNMT3A · N | noncore contact in multidomain chain | 52.7 / 52.7 |
| ZN · O | DNMT3B · K | noncore contact in multidomain chain | — / — |
| ZN · P | DNMT3B · K | noncore contact in multidomain chain | — / — |
| ZN · Q | DNMT3B · K | noncore contact in multidomain chain | — / — |
| ZN · R | DNMT3A · M | noncore contact in multidomain chain | 28.8 / 23.7 |
| ZN · S | DNMT3A · M | noncore contact in multidomain chain | 21.8 / 16.1 |
| ZN · T | DNMT3A · M | noncore contact in multidomain chain | 29.9 / 20.8 |
| ZN · V | DNMT3A · N | noncore contact in multidomain chain | 23.4 / 23.4 |
| ZN · W | DNMT3A · N | noncore contact in multidomain chain | 18.8 / 18.8 |
| ZN · X | DNMT3A · N | noncore contact in multidomain chain | 25.5 / 25.5 |
Biological partners
Histone H3 · histone or histone peptide · label chains ["A","E"]
Histone H4 · histone or histone peptide · label chains ["B","F"]
Histone H2A type 1 · histone or histone peptide · label chains ["C","G"]
Histone H2B 1.1 · histone or histone peptide · label chains ["D","H"]
DNA (162-MER) · nucleic acid · label chains ["I"]
DNA (162-MER) · nucleic acid · label chains ["J"]
Isoform 7 of DNA (cytosine-5)-methyltransferase 3B · protein/peptide · label chains ["K","L"]
DNA (cytosine-5)-methyltransferase 3A · protein/peptide · label chains ["M","N"]
Source interpretation
Focused scientific audit
This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.