Experimental structure
5XSK
Crystal structure of PWWP-DNA complex for human hepatoma-derived growth factor
Original coordinates
Explore the structure
Load the deposited coordinates to rotate, zoom and inspect the structure.
Drag to rotate · scroll or pinch to zoom. Keyboard: focus the view, then use arrow keys to rotate, + / − to zoom, and Home to reset.
Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| Hdgf | C | ["A"] | UP:Q8VHK7:PWWP1 | 58 / 58 | 0 |
| Hdgf | D | ["B"] | UP:Q8VHK7:PWWP1 | 58 / 58 | 0 |
Chemical identity
Chemical components and interpretation
| CCD | Name | Role | Full InChIKey |
|---|---|---|---|
| MPD | (4S)-2-METHYL-2,4-PENTANEDIOL | crystallization additive incidental | SVTBMSDMJJWYQN-YFKPBYRVSA-N |
Geometry, with defined scope
Independent contact evidence
Inspect 4 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| MPD · E | Hdgf · C | native annotation core contact | 3.27 / 3.27 |
| MPD · F | Hdgf · C | native annotation core contact | 3.43 / 3.43 |
| MPD · E | Hdgf · D | native annotation core contact | 3.38 / 3.38 |
| MPD · F | Hdgf · D | native annotation core contact | 3.15 / 3.15 |
Biological partners
DNA (5'-D(P*TP*TP*CP*AP*AP*GP*AP*CP*CP*A)-3') · nucleic acid · label chains ["A"]
DNA (5'-D(P*TP*GP*GP*TP*CP*TP*TP*GP*AP*A)-3') · nucleic acid · label chains ["B"]
Source interpretation
Focused scientific audit
retain with stated interpretation/caveats. Complex supported by DNA and domain-swapped dimer context. Protein labelC/D corresponds to authorA/B. Source maps to ratQ8VHK7 while title and linked publication say human; species ambiguity remains visible.