Experimental structure
11NZ
Cryo-EM structure of human DNMT3A R882H decamer
Original coordinates
Explore the structure
Load the deposited coordinates to rotate, zoom and inspect the structure.
Drag to rotate · scroll or pinch to zoom. Keyboard: focus the view, then use arrow keys to rotate, + / − to zoom, and Home to reset.
Original coordinates are available from a locally verified historical archive or the bundled source and load on request.
Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| DNMT3A | A | ["A"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | B | ["B"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | C | ["C"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | D | ["D"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | E | ["E"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | F | ["F"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | G | ["G"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | H | ["H"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | I | ["I"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | J | ["J"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 34 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| SAH · K | DNMT3A · A | noncore contact in multidomain chain | — / — |
| SAH · L | DNMT3A · B | noncore contact in multidomain chain | 25.5 / 23.3 |
| SAH · S | DNMT3A · C | noncore contact in multidomain chain | — / — |
| SAH · W | DNMT3A · D | noncore contact in multidomain chain | — / — |
| SAH · X | DNMT3A · E | noncore contact in multidomain chain | 26.1 / 20.3 |
| SAH · BA | DNMT3A · F | noncore contact in multidomain chain | 25.9 / 20.4 |
| SAH · IA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| SAH · JA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| SAH · NA | DNMT3A · I | noncore contact in multidomain chain | 25.5 / 23.5 |
| SAH · RA | DNMT3A · J | noncore contact in multidomain chain | — / — |
| ZN · M | DNMT3A · B | noncore contact in multidomain chain | 7.11 / 7.11 |
| ZN · N | DNMT3A · B | noncore contact in multidomain chain | 8.46 / 8.46 |
| ZN · O | DNMT3A · B | noncore contact in multidomain chain | 20.5 / 19.6 |
| ZN · P | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · Q | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · R | DNMT3A · C | noncore contact in multidomain chain | — / — |
| ZN · T | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · U | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · V | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · AA | DNMT3A · E | noncore contact in multidomain chain | 19.5 / 18.6 |
| ZN · Y | DNMT3A · E | noncore contact in multidomain chain | 5.37 / 5.37 |
| ZN · Z | DNMT3A · E | noncore contact in multidomain chain | 8.02 / 8.02 |
| ZN · CA | DNMT3A · F | noncore contact in multidomain chain | 5.28 / 5.28 |
| ZN · DA | DNMT3A · F | noncore contact in multidomain chain | 8.16 / 8.16 |
| ZN · EA | DNMT3A · F | noncore contact in multidomain chain | 19.4 / 18.6 |
| ZN · FA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · GA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · HA | DNMT3A · G | noncore contact in multidomain chain | — / — |
| ZN · KA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · LA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · MA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · OA | DNMT3A · I | noncore contact in multidomain chain | 7.24 / 7.24 |
| ZN · PA | DNMT3A · I | noncore contact in multidomain chain | 8.66 / 8.66 |
| ZN · QA | DNMT3A · I | noncore contact in multidomain chain | 20.4 / 19.6 |
Biological partners
DNA (cytosine-5)-methyltransferase 3A · source-supported homomeric protein assembly · label chains ["A","B","C","D","E","F","G","H","I","J"]
Source interpretation
Focused scientific audit
retain with stated interpretation/caveats. Complex supported as DNMT3A R882H oligomer. Only B/E/F/I show PWWP292–350. Full core position coverage coexists with 500 missing standard core heavy atoms across those chains.