Experimental structure
11OA
Cryo-EM structure of human DNMT3A R882H octadecamer
Complexes
PWWP coordinates observed
ELECTRON MICROSCOPY
Original coordinates
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Coordinate coverage
Mapped chains
Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.
| Protein | Label chain | Author chain | Domain | Observed Cα / core | Observed substitutions |
|---|---|---|---|---|---|
| DNMT3A | A | ["A"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | B | ["B"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | C | ["C"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | D | ["D"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | E | ["E"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | F | ["F"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | G | ["G"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | H | ["H"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | I | ["I"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | J | ["J"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | K | ["K"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | L | ["L"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | M | ["M"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | N | ["N"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | O | ["O"] | UP:Q9Y6K1:PWWP1 | 59 / 59 | 0 |
| DNMT3A | P | ["P"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | Q | ["Q"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
| DNMT3A | R | ["R"] | UP:Q9Y6K1:PWWP1 | 0 / 59 | 0 |
Chemical identity
Chemical components and interpretation
Geometry, with defined scope
Independent contact evidence
Inspect 58 retained contact records
| CCD / instance | Protein chain | Contact class | Minimum core / broader domain distance Å |
|---|---|---|---|
| SAH · V | DNMT3A · A | noncore contact in multidomain chain | — / — |
| SAH · Z | DNMT3A · B | noncore contact in multidomain chain | — / — |
| SAH · AA | DNMT3A · C | noncore contact in multidomain chain | 26.2 / 24 |
| SAH · HA | DNMT3A · D | noncore contact in multidomain chain | — / — |
| SAH · LA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| SAH · MA | DNMT3A · F | noncore contact in multidomain chain | 26.9 / 24.1 |
| SAH · QA | DNMT3A · G | noncore contact in multidomain chain | 26.9 / 24.5 |
| SAH · XA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| SAH · YA | DNMT3A · I | noncore contact in multidomain chain | — / — |
| SAH · FB | DNMT3A · J | noncore contact in multidomain chain | — / — |
| SAH · GB | DNMT3A · L | noncore contact in multidomain chain | — / — |
| SAH · KB | DNMT3A · M | noncore contact in multidomain chain | — / — |
| SAH · LB | DNMT3A · N | noncore contact in multidomain chain | 26.1 / 23.7 |
| SAH · PB | DNMT3A · O | noncore contact in multidomain chain | 25.1 / 23.2 |
| SAH · WB | DNMT3A · P | noncore contact in multidomain chain | — / — |
| SAH · XB | DNMT3A · Q | noncore contact in multidomain chain | — / — |
| ZN · S | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · T | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · U | DNMT3A · A | noncore contact in multidomain chain | — / — |
| ZN · W | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · X | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · Y | DNMT3A · B | noncore contact in multidomain chain | — / — |
| ZN · BA | DNMT3A · C | noncore contact in multidomain chain | 8.07 / 8.07 |
| ZN · CA | DNMT3A · C | noncore contact in multidomain chain | 9.09 / 9.09 |
| ZN · DA | DNMT3A · C | noncore contact in multidomain chain | 20.1 / 19.6 |
| ZN · EA | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · FA | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · GA | DNMT3A · D | noncore contact in multidomain chain | — / — |
| ZN · IA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · JA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · KA | DNMT3A · E | noncore contact in multidomain chain | — / — |
| ZN · NA | DNMT3A · F | noncore contact in multidomain chain | 7.27 / 7.27 |
| ZN · OA | DNMT3A · F | noncore contact in multidomain chain | 8.59 / 8.59 |
| ZN · PA | DNMT3A · F | noncore contact in multidomain chain | 19.8 / 19.6 |
| ZN · RA | DNMT3A · G | noncore contact in multidomain chain | 6.54 / 6.54 |
| ZN · SA | DNMT3A · G | noncore contact in multidomain chain | 7.8 / 7.8 |
| ZN · TA | DNMT3A · G | noncore contact in multidomain chain | 20.1 / 19.8 |
| ZN · UA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · VA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · WA | DNMT3A · H | noncore contact in multidomain chain | — / — |
| ZN · AB | DNMT3A · I | noncore contact in multidomain chain | — / — |
| ZN · BB | DNMT3A · I | noncore contact in multidomain chain | — / — |
| ZN · ZA | DNMT3A · I | noncore contact in multidomain chain | — / — |
| ZN · CB | DNMT3A · J | noncore contact in multidomain chain | — / — |
| ZN · DB | DNMT3A · J | noncore contact in multidomain chain | — / — |
| ZN · EB | DNMT3A · J | noncore contact in multidomain chain | — / — |
| ZN · HB | DNMT3A · M | noncore contact in multidomain chain | — / — |
| ZN · IB | DNMT3A · M | noncore contact in multidomain chain | — / — |
| ZN · JB | DNMT3A · M | noncore contact in multidomain chain | — / — |
| ZN · MB | DNMT3A · N | noncore contact in multidomain chain | 7.62 / 7.62 |
| ZN · NB | DNMT3A · N | noncore contact in multidomain chain | 8.09 / 8.09 |
| ZN · OB | DNMT3A · N | noncore contact in multidomain chain | 19.5 / 19.1 |
| ZN · QB | DNMT3A · O | noncore contact in multidomain chain | 7.55 / 7.55 |
| ZN · RB | DNMT3A · O | noncore contact in multidomain chain | 8.36 / 8.36 |
| ZN · SB | DNMT3A · O | noncore contact in multidomain chain | 19.4 / 19.2 |
| ZN · TB | DNMT3A · P | noncore contact in multidomain chain | — / — |
| ZN · UB | DNMT3A · P | noncore contact in multidomain chain | — / — |
| ZN · VB | DNMT3A · P | noncore contact in multidomain chain | — / — |
Biological partners
DNA (cytosine-5)-methyltransferase 3A · source-supported homomeric protein assembly · label chains ["A","B","C","D","E","F","G","H","I","J","K","L","M","N","O","P","Q","R"]
Source interpretation
Focused scientific audit
retain with stated interpretation/caveats. Complex supported as DNMT3A R882H oligomer. Only C/F/G/N/O show PWWP292–350; each lacks 198 standard heavy atoms in that core. Do not infer intact aromatic-cage geometry.