Experimental structure

9E00

Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome

Unclassified_Review No mapped PWWP coordinates ELECTRON MICROSCOPY

Original coordinates

Explore the structure

Your molecular view is ready

Load the deposited coordinates to rotate, zoom and inspect the structure.

Drag to rotate · scroll or pinch to zoom. Keyboard: focus the view, then use arrow keys to rotate, + / − to zoom, and Home to reset.

Original coordinates are available from a locally verified historical archive or the bundled source and load on request.

Coordinate coverage

8 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

Protein	Label chain	Author chain	Domain	Observed Cα / core
DNMT3A	U	["U"]	UP:Q9Y6K1:PWWP1	0 / 59
DNMT3A	V	["Y"]	UP:Q9Y6K1:PWWP1	0 / 59
DNMT3A	Y	["W"]	UP:Q9Y6K1:PWWP1	0 / 59
DNMT3A	Z	["K"]	UP:Q9Y6K1:PWWP1	0 / 59
DNMT3B	S	["V"]	UP:Q9UBC3:PWWP1	0 / 59
DNMT3B	T	["Z"]	UP:Q9UBC3:PWWP1	0 / 59
DNMT3B	W	["L"]	UP:Q9UBC3:PWWP1	0 / 59
DNMT3B	X	["X"]	UP:Q9UBC3:PWWP1	0 / 59

Chemical identity

2 component records

CCD	Name	Role	Full InChIKey
ZN	ZINC ION	ion/cofactor_requires_context incidental	PTFCDOFLOPIGGS-UHFFFAOYSA-N
SAH	S-ADENOSYL-L-HOMOCYSTEINE	biological cofactor functional	ZJUKTBDSGOFHSH-WFMPWKQPSA-N

Geometry, with defined scope

Inspect 13 retained contact records

CCD / instance	Protein chain	Contact class	Minimum core / broader domain distance Å
SAH · DA	DNMT3A · U	noncore contact in multidomain chain	— / —
SAH · HA	DNMT3A · V	noncore contact in multidomain chain	— / —
SAH · LA	DNMT3A · Y	noncore contact in multidomain chain	— / —
SAH · MA	DNMT3A · Z	noncore contact in multidomain chain	— / —
ZN · AA	DNMT3B · S	noncore contact in multidomain chain	— / —
ZN · BA	DNMT3B · S	noncore contact in multidomain chain	— / —
ZN · CA	DNMT3B · S	noncore contact in multidomain chain	— / —
ZN · EA	DNMT3A · V	noncore contact in multidomain chain	— / —
ZN · FA	DNMT3A · V	noncore contact in multidomain chain	— / —
ZN · GA	DNMT3A · V	noncore contact in multidomain chain	— / —
ZN · IA	DNMT3B · W	noncore contact in multidomain chain	— / —
ZN · JA	DNMT3B · W	noncore contact in multidomain chain	— / —
ZN · KA	DNMT3B · W	noncore contact in multidomain chain	— / —

Histone H3.2 · histone or histone peptide · label chains ["A","E","I","M"]

Histone H4 · histone or histone peptide · label chains ["B","F","J","N"]

Histone H2A · histone or histone peptide · label chains ["C","G","K","O"]

Histone H2B · histone or histone peptide · label chains ["D","H","L","P"]

DNA (321-MER) · nucleic acid · label chains ["Q"]

DNA (321-MER) · nucleic acid · label chains ["R"]

Isoform 3 of DNA (cytosine-5)-methyltransferase 3B · protein/peptide · label chains ["S","T","W","X"]

DNA (cytosine-5)-methyltransferase 3A · protein/peptide · label chains ["U","V","Y","Z"]

Source interpretation

This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.