PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Experimental structure

11OI

Cryo-EM structure of human DNMT3A homo-hexamer

Complexes PWWP coordinates observed ELECTRON MICROSCOPY

Original coordinates

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PDB deposition
11OI Deposited model
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.

Coordinate coverage

Mapped chains

6 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

ProteinLabel chainAuthor chainDomainObserved Cα / coreObserved substitutions
DNMT3AA["C"]UP:Q9Y6K1:PWWP159 / 590
DNMT3AB["E"]UP:Q9Y6K1:PWWP10 / 590
DNMT3AC["F"]UP:Q9Y6K1:PWWP10 / 590
DNMT3AD["D"]UP:Q9Y6K1:PWWP10 / 590
DNMT3AE["A"]UP:Q9Y6K1:PWWP10 / 590
DNMT3AF["B"]UP:Q9Y6K1:PWWP159 / 590

Chemical identity

Chemical components and interpretation

2 component records
CCDNameRoleFull InChIKey
SAHS-ADENOSYL-L-HOMOCYSTEINEbiological cofactor
functional		ZJUKTBDSGOFHSH-WFMPWKQPSA-N
ZNZINC IONion/cofactor_requires_context
incidental		PTFCDOFLOPIGGS-UHFFFAOYSA-N

Geometry, with defined scope

Independent contact evidence

Inspect 16 retained contact records
CCD / instanceProtein chainContact classMinimum core / broader domain distance Å
SAH · GDNMT3A · Anoncore contact in multidomain chain25.4 / 20.7
SAH · KDNMT3A · Dnoncore contact in multidomain chain— / —
SAH · ODNMT3A · Enoncore contact in multidomain chain— / —
SAH · SDNMT3A · Fnoncore contact in multidomain chain25.2 / 23.3
ZN · HDNMT3A · Anoncore contact in multidomain chain6.85 / 6.85
ZN · IDNMT3A · Anoncore contact in multidomain chain6.8 / 6.8
ZN · JDNMT3A · Anoncore contact in multidomain chain19.5 / 17.1
ZN · LDNMT3A · Dnoncore contact in multidomain chain— / —
ZN · MDNMT3A · Dnoncore contact in multidomain chain— / —
ZN · NDNMT3A · Dnoncore contact in multidomain chain— / —
ZN · PDNMT3A · Enoncore contact in multidomain chain— / —
ZN · QDNMT3A · Enoncore contact in multidomain chain— / —
ZN · RDNMT3A · Enoncore contact in multidomain chain— / —
ZN · TDNMT3A · Fnoncore contact in multidomain chain7.65 / 7.65
ZN · UDNMT3A · Fnoncore contact in multidomain chain9.29 / 9.29
ZN · VDNMT3A · Fnoncore contact in multidomain chain20.5 / 19.6

Biological partners

DNA (cytosine-5)-methyltransferase 3A · source-supported homomeric protein assembly · label chains ["A","B","C","D","E","F"]

Source interpretation

Focused scientific audit

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This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.