Experimental structure

29HH

Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2, UNC10088 and Bach1

Complexes PWWP coordinates observed ELECTRON MICROSCOPY

Original coordinates

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Coordinate coverage

2 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

Protein	Label chain	Author chain	Domain	Observed Cα / core	Observed substitutions
NSD2	B	["B"]	UP:O96028:PWWP1	65 / 65	0
NSD2	B	["B"]	UP:O96028:PWWP2	0 / 63	0

Chemical identity

1 component records

CCD	Name	Role	Full InChIKey
A1J20	~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide	experimentally studied degrader functional	DEWAWAOVHSEUOF-UHFFFAOYSA-N

Geometry, with defined scope

Inspect 2 retained contact records

CCD / instance	Protein chain	Contact class	Minimum core / broader domain distance Å
A1J20 · H	NSD2 · B	native annotation core contact	2.66 / 2.66
A1J20 · H	NSD2 · B	noncore contact in multidomain chain	— / —

F-box only protein 22 · protein/peptide · label chains ["A"]

S-phase kinase-associated protein 1 · protein/peptide · label chains ["C"]

Cullin-1 · protein/peptide · label chains ["D"]

E3 ubiquitin-protein ligase RBX1 · protein/peptide · label chains ["E"]

Transcription regulator protein BACH1 · protein/peptide · label chains ["F","G"]

Source interpretation

This entry was included in all-entry coordinate/contact calculations but not in the 36-entry focused structural sample.