{
  "metadata": {
    "analysis_id": "PWWP-Discovery-1.0.0",
    "version": "1.0.0",
    "scientific_snapshot": "v1.2",
    "data_as_of": "2026-10-24",
    "annotation_snapshot_as_of": "2026-10-26",
    "scope": "Source-indexed publication and deposition chronology, canonical protein features, mapped deposited constructs, validated isoform core retention.",
    "date_policy": "Publication year, PDB deposition day, and initial release day remain distinct; no historical priority claims.",
    "counts": {
      "raw_bibliography_records": 128,
      "literature_records": 128,
      "dated_publications": 98,
      "research_publication_events": 97,
      "methodological_publication_events": 1,
      "undated_literature_records": 29,
      "experimental_entries": 230,
      "deposition_events": 230,
      "release_events": 230,
      "proteins": 39,
      "sequence_matched_uniprot_sources": 39,
      "additional_canonical_features": 71,
      "validated_isoform_domain_rows": 103
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    "limitations": [
      "Bibliographic metadata and selected full-text verification have different scopes, shown per source. This is not a systematic literature review.",
      "The chronology indexes recorded dates; it does not assign discovery priority or infer milestones from citation order.",
      "The Phenix methods citation is retained as methodological context, excluded from the default research timeline, and available in the full literature index and all-source scope.",
      "Publication dates have year precision in the frozen bibliography. The year is not presented as 1 January.",
      "PDB entries can be associated with a protein without observed PWWP coordinates; observed-coordinate status is explicit.",
      "Current UniProt features are accepted only when the canonical sequence exactly matches the frozen Atlas sequence. Annotation evidence is not necessarily experimental evidence.",
      "Mapped construct bars represent source-supported canonical segments, not inferred complete construct termini or complete folded-domain boundaries.",
      "Isoform rows reuse source-validated PWWP core correspondence; other-domain architectures are not inferred for isoforms.",
      "Ligand names are linked only through curated assay/preparation records. Structural occupancy, preparation identity, and activity remain separate.",
      "Missing annotations, contacts, dates, or ligand links indicate missing curation in this snapshot, not biological absence."
    ]
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        "PMID:40959233"
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        "Ackroyd B",
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        {
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        },
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        },
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        },
        {
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    },
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        "PMID:39031937"
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        },
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      "reference_ids": [
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      "title": "Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.",
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        "Carlino, L.",
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      "reference_ids": [
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      "reference_id": "PMID:39461037",
      "reference_ids": [
        "PMID:39461037"
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      "title": "Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.",
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      ],
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          "domain_ids": [
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        }
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      "date_precision": "year",
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      "is_publication": true
    },
    {
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      "reference_id": "PMID:31634469",
      "reference_ids": [
        "PMID:31634469"
      ],
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      ],
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        "Liebschner, D.",
        "Afonine, P.V.",
        "Baker, M.L.",
        "Bunkoczi, G.",
        "Chen, V.B.",
        "Croll, T.I.",
        "Hintze, B.",
        "Hung, L.W.",
        "Jain, S.",
        "McCoy, A.J.",
        "Moriarty, N.W.",
        "Oeffner, R.D.",
        "Poon, B.K.",
        "Prisant, M.G.",
        "Read, R.J.",
        "Richardson, J.S.",
        "Richardson, D.C.",
        "Sammito, M.D.",
        "Sobolev, O.V.",
        "Stockwell, D.H.",
        "Terwilliger, T.C.",
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        "Videau, L.L.",
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        "Perrett S",
        "Feng Y"
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      "reference_ids": [
        "PMID:30626613"
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      "title": "Solution structure of TbTFIIS2-2 PWWP domain from Trypanosoma brucei and its binding to H4K17me3 and H3K32me3.",
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        "Gao J",
        "Zhang J",
        "Zhang X",
        "Xu C",
        "Liao S",
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    },
    {
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      "reference_ids": [
        "PMID:31162607"
      ],
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        "Tian W",
        "Yan P",
        "Xu N",
        "Chakravorty A",
        "Liefke R",
        "Xi Q",
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      "journal": "Nucleic acids research",
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      ],
      "structures": [
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          "pdb_id": "6IIP",
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        },
        {
          "pdb_id": "6IIQ",
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    },
    {
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      "reference_id": "PMID:30228260",
      "reference_ids": [
        "PMID:30228260"
      ],
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        "Wei G",
        "Millard CJ",
        "Fischer R",
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      ],
      "proteins": [
        {
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      "reference_id": "PMID:29321480",
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        "Chuankhayan P",
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      ],
      "proteins": [
        {
          "protein_id": "UP:P51858",
          "uniprot": "P51858",
          "gene": "HDGF",
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      ],
      "structures": [
        {
          "pdb_id": "5XSK",
          "in_atlas": true,
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        },
        {
          "pdb_id": "5XSL",
          "in_atlas": true,
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        }
      ],
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      "date_precision": "year",
      "date_note": "Publication year recorded in the frozen bibliography; no month or day inferred.",
      "is_publication": true
    },
    {
      "id": "DOI:10.1038/s41467-018-06665-5",
      "reference_id": "PMID:30327463",
      "reference_ids": [
        "PMID:30327463"
      ],
      "title": "PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.",
      "authors": [
        "Link S",
        "Spitzer RMM",
        "Sana M",
        "Torrado M",
        "Völker-Albert MC",
        "Keilhauer EC",
        "Burgold T",
        "Pünzeler S",
        "Low JKK",
        "Lindström I",
        "Nist A",
        "Regnard C",
        "Stiewe T",
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        "Mann M",
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        "Hake SB"
      ],
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      ],
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      "is_publication": true
    },
    {
      "id": "DOI:10.15252/embj.201695757",
      "reference_id": "PMID:28645917",
      "reference_ids": [
        "PMID:28645917"
      ],
      "title": "Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.",
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        "Link S",
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        "Kusakabe M",
        "Vardabasso C",
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        "Leonhardt H",
        "Mann M",
        "Rupp RA",
        "Hake SB"
      ],
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      ],
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      "journal": "The EMBO journal",
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      "verification_level": "bibliographic_metadata_and_abstract_verified",
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      ],
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      ],
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      "is_publication": true
    },
    {
      "id": "DOI:10.1016/j.str.2017.08.014",
      "reference_id": "PMID:28966017",
      "reference_ids": [
        "PMID:28966017"
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        "Tsujimoto N",
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      ],
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      ],
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        "Sawada K",
        "Zhang X",
        "Cheng X"
      ],
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      ],
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          "pdb_id": "1KHC",
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        }
      ],
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      "ligands": [],
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        "PMID:10802047"
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        "Stec I",
        "Nagl SB",
        "van Ommen GJ",
        "den Dunnen JT"
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        "DONG, A.",
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      "citation_role_label": "Experimental research",
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      ],
      "structures": [],
      "domains": [],
      "ligands": [],
      "date_precision": "year",
      "date_note": "Publication year recorded in the frozen bibliography; no month or day inferred.",
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      "kind": "release",
      "kind_label": "PDB initial release",
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      "sort_date": "2010-01-12",
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          "protein_id": "UP:P55201",
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      ],
      "structures": [
        {
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          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:P55201:PWWP1",
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      ],
      "ligands": [],
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      "date_precision": "day",
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    },
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      "kind_label": "PDB deposition",
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        }
      ],
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        {
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      ],
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      "kind_label": "PDB deposition",
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        {
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      "observed_pwwp": true
    },
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      "kind_label": "PDB deposition",
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      "sort_date": "2010-02-02",
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    },
    {
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      "kind_label": "PDB deposition",
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      "sort_date": "2010-02-02",
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      "date_precision": "day",
      "source_date": "2010-04-21T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3MO8:deposition",
      "id": "3MO8",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2010-04-22",
      "sort_date": "2010-04-22",
      "year": 2010,
      "title": "PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide",
      "url": "https://www.rcsb.org/structure/3MO8",
      "proteins": [
        {
          "protein_id": "UP:P55201",
          "uniprot": "P55201",
          "gene": "BRPF1",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3MO8",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:P55201:PWWP1",
          "gene": "BRPF1",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-04-22T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3MO8:release",
      "id": "3MO8",
      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2010-06-02",
      "sort_date": "2010-06-02",
      "year": 2010,
      "title": "PWWP Domain of Human Bromodomain and PHD finger-containing protein 1 In Complex with Trimethylated H3K36 Peptide",
      "url": "https://www.rcsb.org/structure/3MO8",
      "proteins": [
        {
          "protein_id": "UP:P55201",
          "uniprot": "P55201",
          "gene": "BRPF1",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3MO8",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:P55201:PWWP1",
          "gene": "BRPF1",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-06-02T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3PFS:deposition",
      "id": "3PFS",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2010-10-29",
      "sort_date": "2010-10-29",
      "year": 2010,
      "title": "PWWP Domain of Human Bromodomain and PHD finger-containing protein 3",
      "url": "https://www.rcsb.org/structure/3PFS",
      "proteins": [
        {
          "protein_id": "UP:Q9ULD4",
          "uniprot": "Q9ULD4",
          "gene": "BRPF3",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3PFS",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q9ULD4:PWWP1",
          "gene": "BRPF3",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-10-29T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3PFS:release",
      "id": "3PFS",
      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2010-11-10",
      "sort_date": "2010-11-10",
      "year": 2010,
      "title": "PWWP Domain of Human Bromodomain and PHD finger-containing protein 3",
      "url": "https://www.rcsb.org/structure/3PFS",
      "proteins": [
        {
          "protein_id": "UP:Q9ULD4",
          "uniprot": "Q9ULD4",
          "gene": "BRPF3",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3PFS",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q9ULD4:PWWP1",
          "gene": "BRPF3",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-11-10T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3PMI:deposition",
      "id": "3PMI",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2010-11-17",
      "sort_date": "2010-11-17",
      "year": 2010,
      "title": "PWWP Domain of Human Mutated Melanoma-Associated Antigen 1",
      "url": "https://www.rcsb.org/structure/3PMI",
      "proteins": [
        {
          "protein_id": "UP:Q2TAK8",
          "uniprot": "Q2TAK8",
          "gene": "PWWP3A",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3PMI",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q2TAK8:PWWP1",
          "gene": "PWWP3A",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-11-17T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3PMI:release",
      "id": "3PMI",
      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2010-12-15",
      "sort_date": "2010-12-15",
      "year": 2010,
      "title": "PWWP Domain of Human Mutated Melanoma-Associated Antigen 1",
      "url": "https://www.rcsb.org/structure/3PMI",
      "proteins": [
        {
          "protein_id": "UP:Q2TAK8",
          "uniprot": "Q2TAK8",
          "gene": "PWWP3A",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3PMI",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q2TAK8:PWWP1",
          "gene": "PWWP3A",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2010-12-15T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "id": "DOI:10.1371/journal.pone.0018919",
      "reference_id": "PMID:21720545",
      "reference_ids": [
        "PMID:21720545"
      ],
      "title": "Structural and histone binding ability characterizations of human PWWP domains.",
      "authors": [
        "Wu H",
        "Zeng H",
        "Lam R",
        "Tempel W",
        "Amaya MF",
        "Xu C",
        "Dombrovski L",
        "Qiu W",
        "Wang Y",
        "Min J"
      ],
      "year": 2011,
      "year_values": [
        2011
      ],
      "year_conflict": false,
      "journal": "PloS one",
      "doi": "10.1371/journal.pone.0018919",
      "pmid": 21720545,
      "url": "https://doi.org/10.1371/journal.pone.0018919",
      "source_type": "primary_experimental_research",
      "citation_role": "pwwp_research_context",
      "citation_role_label": "Experimental research",
      "citation_role_basis": "Display scope follows the frozen bibliography record; no new functional milestone is inferred.",
      "relevance": "Family-wide human PWWP structure and histone binding comparison",
      "verification_level": "primary_full_text_sections_verified",
      "source_records": [
        {
          "reference_id": "PMID:21720545",
          "year": 2011,
          "source_type": "primary_experimental_research",
          "verification_level": "primary_full_text_sections_verified",
          "url": "https://doi.org/10.1371/journal.pone.0018919"
        }
      ],
      "proteins": [
        {
          "protein_id": "UP:O95696",
          "uniprot": "O95696",
          "gene": "BRD1",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:P55201",
          "uniprot": "P55201",
          "gene": "BRPF1",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:Q2TAK8",
          "uniprot": "Q2TAK8",
          "gene": "PWWP3A",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:Q7Z4V5",
          "uniprot": "Q7Z4V5",
          "gene": "HDGFL2",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:Q9UBC3",
          "uniprot": "Q9UBC3",
          "gene": "DNMT3B",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:Q9ULD4",
          "uniprot": "Q9ULD4",
          "gene": "BRPF3",
          "organism": "Homo sapiens"
        },
        {
          "protein_id": "UP:Q9Y6K1",
          "uniprot": "Q9Y6K1",
          "gene": "DNMT3A",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3EAE",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3L42",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3LLR",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3LYI",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3MO8",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3PFS",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3PMI",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3QBY",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3QJ6",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "3QKJ",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q7Z4V5:PWWP1",
          "gene": "HDGFL2",
          "domain_name": "PWWP1"
        },
        {
          "domain_id": "UP:Q9UBC3:PWWP1",
          "gene": "DNMT3B",
          "domain_name": "PWWP1"
        },
        {
          "domain_id": "UP:Q9Y6K1:PWWP1",
          "gene": "DNMT3A",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [
        {
          "name": "Bis-Tris",
          "preparation_id": "PREP:BIS-TRIS",
          "chemical_identity_status": "exact_single_CCD_identity",
          "assay_ids": [
            "PWWP:ASSAY:0033",
            "PWWP:ASSAY:0034"
          ],
          "evidence_classes": [
            "structural_occupancy_association"
          ],
          "domain_ids": [
            "UP:Q9UBC3:PWWP1",
            "UP:Q9Y6K1:PWWP1"
          ]
        },
        {
          "name": "H4K20me3 peptide / trimethyllysine monomer",
          "preparation_id": "PREP:H4K20me3_11mer",
          "chemical_identity_status": "defined_modified_peptide_sequence_not_monomer_identity",
          "assay_ids": [
            "PWWP11:ASSAY:0010",
            "PWWP:ASSAY:0036"
          ],
          "evidence_classes": [
            "qualitative_weak_binding",
            "structural_occupancy_association"
          ],
          "domain_ids": [
            "UP:Q7Z4V5:PWWP1"
          ]
        }
      ],
      "date_precision": "year",
      "date_note": "Publication year recorded in the frozen bibliography; no month or day inferred.",
      "is_publication": true,
      "event_id": "PUB:DOI:10.1371/journal.pone.0018919",
      "kind": "publication",
      "kind_label": "Publication year",
      "date": "2011",
      "sort_date": "2011-00-00"
    },
    {
      "event_id": "PDB:2L89:deposition",
      "id": "2L89",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2011-01-07",
      "sort_date": "2011-01-07",
      "year": 2011,
      "title": "Solution structure of Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA",
      "url": "https://www.rcsb.org/structure/2L89",
      "proteins": [
        {
          "protein_id": "UP:O59676",
          "uniprot": "O59676",
          "gene": "pdp1",
          "organism": "Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
        }
      ],
      "structures": [
        {
          "pdb_id": "2L89",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:O59676:PWWP1",
          "gene": "pdp1",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1042/bj20111885",
          "title": "Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.",
          "url": "https://doi.org/10.1042/bj20111885",
          "doi": "10.1042/bj20111885",
          "pmid": 22150589,
          "year": 2012
        }
      ],
      "date_precision": "day",
      "source_date": "2011-01-07T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3QBY:deposition",
      "id": "3QBY",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2011-01-14",
      "sort_date": "2011-01-14",
      "year": 2011,
      "title": "Crystal structure of the PWWP domain of human Hepatoma-derived growth factor 2",
      "url": "https://www.rcsb.org/structure/3QBY",
      "proteins": [
        {
          "protein_id": "UP:Q7Z4V5",
          "uniprot": "Q7Z4V5",
          "gene": "HDGFL2",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3QBY",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q7Z4V5:PWWP1",
          "gene": "HDGFL2",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2011-01-14T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3QJ6:deposition",
      "id": "3QJ6",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2011-01-28",
      "sort_date": "2011-01-28",
      "year": 2011,
      "title": "The crystal structure of PWWP domain of human Hepatoma-derived growth factor 2 in complex with H3K79me3 peptide",
      "url": "https://www.rcsb.org/structure/3QJ6",
      "proteins": [
        {
          "protein_id": "UP:Q7Z4V5",
          "uniprot": "Q7Z4V5",
          "gene": "HDGFL2",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3QJ6",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q7Z4V5:PWWP1",
          "gene": "HDGFL2",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2011-01-28T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:3QKJ:deposition",
      "id": "3QKJ",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2011-02-01",
      "sort_date": "2011-02-01",
      "year": 2011,
      "title": "The PWWP domain of human DNA (CYTOSINE-5-)-METHYLTRANSFERASE 3 BETA in complex with a bis-tris molecule",
      "url": "https://www.rcsb.org/structure/3QKJ",
      "proteins": [
        {
          "protein_id": "UP:Q9UBC3",
          "uniprot": "Q9UBC3",
          "gene": "DNMT3B",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "3QKJ",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q9UBC3:PWWP1",
          "gene": "DNMT3B",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1371/journal.pone.0018919",
          "title": "Structural and histone binding ability characterizations of human PWWP domains.",
          "url": "https://doi.org/10.1371/journal.pone.0018919",
          "doi": "10.1371/journal.pone.0018919",
          "pmid": 21720545,
          "year": 2011
        }
      ],
      "date_precision": "day",
      "source_date": "2011-02-01T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
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    },
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      ],
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      "date": "2017-05-03",
      "sort_date": "2017-05-03",
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      "sort_date": "2017-06-28",
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      "title": "A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.",
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        "Wei G",
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      "title": "PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.",
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        "Torrado M",
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      "title": "Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor.",
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        "Huang YC",
        "Huang ST",
        "Hsieh YC",
        "Guan HH",
        "Chen NC",
        "Chuankhayan P",
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        "Tai MH",
        "Chen CJ"
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          "protein_id": "UP:P51858",
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        {
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    {
      "event_id": "PDB:6G24:deposition",
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      "kind_label": "PDB deposition",
      "date": "2018-03-22",
      "sort_date": "2018-03-22",
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      "reference_ids": [
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        "Holzer K",
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      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:6KCP:deposition",
      "id": "6KCP",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2019-06-28",
      "sort_date": "2019-06-28",
      "year": 2019,
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        {
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          "uniprot": "Q9VAA9",
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          "organism": "Drosophila melanogaster"
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      ],
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        {
          "pdb_id": "6KCP",
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          "observed_pwwp": true
        }
      ],
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        {
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        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "REF:PDB:6KCP:primary",
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          "pmid": null,
          "year": null
        }
      ],
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      "observed_pwwp": true
    },
    {
      "event_id": "PDB:6KCU:deposition",
      "id": "6KCU",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2019-06-29",
      "sort_date": "2019-06-29",
      "year": 2019,
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        {
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      ],
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        {
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        }
      ],
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        {
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      ],
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        {
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          "pmid": null,
          "year": null
        }
      ],
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      "observed_pwwp": true
    },
    {
      "event_id": "PDB:6KD6:deposition",
      "id": "6KD6",
      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2019-07-01",
      "sort_date": "2019-07-01",
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        {
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        }
      ],
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        {
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          "observed_pwwp": true
        }
      ],
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        {
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        }
      ],
      "ligands": [],
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        {
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          "title": "Structural basis of thymidine-rich DNA recognition by Drosophila P75 PWWP domain.",
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          "doi": "10.1038/s42003-025-07895-2",
          "pmid": 40089621,
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        },
        {
          "id": "REF:PDB:6KD6:primary",
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          "pmid": null,
          "year": null
        }
      ],
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    },
    {
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      "kind_label": "PDB deposition",
      "date": "2019-09-20",
      "sort_date": "2019-09-20",
      "year": 2019,
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          "protein_id": "UP:O96028",
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          "organism": "Homo sapiens"
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      ],
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          "observed_pwwp": true
        }
      ],
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        {
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        }
      ],
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        {
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          "doi": "10.1021/acs.jmedchem.0c01768",
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        }
      ],
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    },
    {
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      "kind": "deposition",
      "kind_label": "PDB deposition",
      "date": "2019-11-05",
      "sort_date": "2019-11-05",
      "year": 2019,
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      ],
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          "pdb_id": "6L87",
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          "observed_pwwp": true
        }
      ],
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        {
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          "doi": "10.1016/j.jmb.2021.167224",
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        }
      ],
      "date_precision": "day",
      "source_date": "2019-11-05T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
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    },
    {
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      "sort_date": "2019-11-13",
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      "title": "PWWP1 domain of NSD2 in complex with MR837",
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      "proteins": [
        {
          "protein_id": "UP:O96028",
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          "organism": "Homo sapiens"
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      ],
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        {
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        }
      ],
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        {
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        }
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      "kind_label": "PDB initial release",
      "date": "2019-12-18",
      "sort_date": "2019-12-18",
      "year": 2019,
      "title": "Structure of LEDGF PWWP domain bound H3K36 methylated nucleosome",
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      "proteins": [
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        {
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          "doi": "10.1038/s41594-019-0345-4",
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    {
      "id": "DOI:10.1038/s41467-020-18874-y",
      "reference_id": "REF:PDB:7PEL:primary",
      "reference_ids": [
        "REF:PDB:7PEL:primary"
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      "title": "Cryo-EM structure of the deltaretroviral intasome in complex with the PP2A regulatory subunit B56gamma.",
      "authors": [
        "Barski, M.S.",
        "Minnell, J.J.",
        "Hodakova, Z.",
        "Pye, V.E.",
        "Nans, A.",
        "Cherepanov, P.",
        "Maertens, G.N."
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      "journal": "Nat Commun",
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      ],
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          "pdb_id": "7PEL",
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          "observed_pwwp": false
        }
      ],
      "domains": [],
      "ligands": [],
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      "reference_id": "PMID:32968275",
      "reference_ids": [
        "PMID:32968275"
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      "title": "Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B.",
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        "Xu TH",
        "Liu M",
        "Zhou XE",
        "Liang G",
        "Zhao G",
        "Xu HE",
        "Melcher K",
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      "ligands": [],
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        "Farnung L",
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      ],
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      "ligands": [],
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      "sort_date": "2020-04-08",
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          "protein_id": "UP:Q9UBC3",
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      ],
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        {
          "pdb_id": "6R3E",
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          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q9UBC3:PWWP1",
          "gene": "DNMT3B",
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      ],
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      "references": [
        {
          "id": "REF:PDB:6R3E:primary",
          "title": "Targeting PWWP domain of DNMT3B for epigenetic cancer therapy: identification and structural characterization of potential protein-protein interaction inhibitors",
          "url": "https://www.rcsb.org/structure/6R3E",
          "doi": null,
          "pmid": null,
          "year": null
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      ],
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      "source_date": "2020-04-08T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
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      "observed_pwwp": true
    },
    {
      "event_id": "PDB:6XCG:deposition",
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      "kind_label": "PDB deposition",
      "date": "2020-06-08",
      "sort_date": "2020-06-08",
      "year": 2020,
      "title": "Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934",
      "url": "https://www.rcsb.org/structure/6XCG",
      "proteins": [
        {
          "protein_id": "UP:O96028",
          "uniprot": "O96028",
          "gene": "NSD2",
          "organism": "Homo sapiens"
        }
      ],
      "structures": [
        {
          "pdb_id": "6XCG",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:O96028:PWWP1",
          "gene": "NSD2",
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        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1038/s41589-021-00898-0",
          "title": "A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.",
          "url": "https://doi.org/10.1038/s41589-021-00898-0",
          "doi": "10.1038/s41589-021-00898-0",
          "pmid": 34782742,
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      ],
      "date_precision": "day",
      "source_date": "2020-06-08T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
      "event_id": "PDB:6PA7:release",
      "id": "6PA7",
      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2020-06-17",
      "sort_date": "2020-06-17",
      "year": 2020,
      "title": "The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.",
      "url": "https://www.rcsb.org/structure/6PA7",
      "proteins": [
        {
          "protein_id": "UP:Q9UBC3",
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      "reference_id": "PMID:33556623",
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        "PMID:33556623"
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      "title": "Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.",
      "authors": [
        "Zhang M",
        "Lei M",
        "Qin S",
        "Dong A",
        "Yang A",
        "Li Y",
        "Loppnau P",
        "Hughes TR",
        "Min J",
        "Liu Y"
      ],
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        {
          "name": "BPP",
          "preparation_id": "PREP:BPP",
          "chemical_identity_status": "exact_single_CCD_identity",
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            "PWWP:ASSAY:0011",
            "PWWP:ASSAY:0012",
            "PWWP:ASSAY:0013"
          ],
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          ],
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        },
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          "name": "varenicline",
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            "PWWP:ASSAY:0010"
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      "date_note": "Publication year recorded in the frozen bibliography; no month or day inferred.",
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      "id": "DOI:10.1016/j.ejmech.2024.116960",
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      "reference_ids": [
        "PMID:39461037"
      ],
      "title": "Rational fragment-based design of compounds targeting the PWWP domain of the HRP family.",
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        "Vantieghem T",
        "Aslam NA",
        "Osipov EM",
        "Akele M",
        "Van Belle S",
        "Beelen S",
        "Drexler M",
        "Paulovcakova T",
        "Lux V",
        "Fearon D",
        "Douangamath A",
        "von Delft F",
        "Christ F",
        "Veverka V",
        "Verwilst P",
        "Van Aerschot A",
        "Debyser Z",
        "Strelkov SV"
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          "observed_pwwp": true
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        },
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        },
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        },
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        },
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        },
        {
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          "observed_pwwp": true
        },
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          "observed_pwwp": true
        },
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          "pdb_id": "7HGZ",
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        },
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          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "7HHA",
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          "observed_pwwp": true
        },
        {
          "pdb_id": "7HHB",
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        },
        {
          "pdb_id": "7HHC",
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          "observed_pwwp": true
        },
        {
          "pdb_id": "7HHD",
          "in_atlas": true,
          "observed_pwwp": true
        },
        {
          "pdb_id": "7HHE",
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          "observed_pwwp": true
        },
        {
          "pdb_id": "7HHF",
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          "observed_pwwp": true
        },
        {
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        },
        {
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        },
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          "observed_pwwp": true
        },
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        },
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      "ligands": [],
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        "Carlino, L.",
        "Astles, P.C.",
        "Ackroyd, B.",
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        "Fawcett, C.",
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        "Milbradt, A.G.",
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        "Rivers, E.L.",
        "Underwood, E.",
        "Webb, A."
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      "reference_ids": [
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      "title": "The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.",
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        "Clifford, G.",
        "Rolls, W.",
        "Pasquier, M.",
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      ],
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        "Li, Y.",
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        "Li, Y.",
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      "kind": "publication",
      "kind_label": "Publication year",
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    },
    {
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      "reference_id": "REF:PDB:9Y60:primary",
      "reference_ids": [
        "REF:PDB:9Y60:primary"
      ],
      "title": "NSD2 degradation remediates the oncogenic cistrome in t(4;14) multiple myeloma.",
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        "Hu, B.",
        "Edwards, J.T.",
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        "Gamez, J.",
        "Echeagaray, O.",
        "Hess, K.",
        "Ren, Y.",
        "Anderson, D.",
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        "Zhu, J.",
        "Johnson, S.",
        "Deb, G.",
        "Jankeel, D.",
        "Janardhanan, P.",
        "Leisten, J.",
        "Peng, S.",
        "Christoforou, A.",
        "Stong, N.",
        "Fontanillo, C.",
        "Bjorklund, C.C.",
        "Hagner, P.R.",
        "Gandhi, A.K.",
        "Martinez-Climent, J.A.",
        "Narla, R.K.",
        "Lopez-Girona, A.",
        "Rolfe, M.",
        "Bence, N.",
        "Mortensen, D.S.",
        "Groocock, L."
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      "year_values": [
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      "year_conflict": false,
      "journal": "Blood",
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        },
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      "ligands": [],
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      "id": "DOI:10.3390/biom16050716",
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        "PMID:42194065"
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        {
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      "date_precision": "year",
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          "pmid": null,
          "year": null
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      ],
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      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
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      "observed_pwwp": false
    },
    {
      "event_id": "PDB:9E05:release",
      "id": "9E05",
      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2026-02-18",
      "sort_date": "2026-02-18",
      "year": 2026,
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          "gene": "DNMT3A",
          "organism": "Homo sapiens"
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      ],
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          "pdb_id": "9E05",
          "in_atlas": true,
          "observed_pwwp": true
        }
      ],
      "domains": [
        {
          "domain_id": "UP:Q9Y6K1:PWWP1",
          "gene": "DNMT3A",
          "domain_name": "PWWP1"
        }
      ],
      "ligands": [],
      "references": [
        {
          "id": "DOI:10.1016/j.molcel.2026.01.030",
          "title": "Nucleosome spacing regulates linker methylation by DNMT3A2/3B3.",
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          "doi": "10.1016/j.molcel.2026.01.030",
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      ],
      "date_precision": "day",
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      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
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      "observed_pwwp": true
    },
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        {
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      "observed_pwwp": true
    },
    {
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      "kind": "release",
      "kind_label": "PDB initial release",
      "date": "2026-02-18",
      "sort_date": "2026-02-18",
      "year": 2026,
      "title": "A focus of tetramer (2) of the cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome",
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      "proteins": [
        {
          "protein_id": "UP:Q9UBC3",
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          "gene": "DNMT3B",
          "organism": "Homo sapiens"
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        {
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          "uniprot": "Q9Y6K1",
          "gene": "DNMT3A",
          "organism": "Homo sapiens"
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      ],
      "structures": [
        {
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          "in_atlas": true,
          "observed_pwwp": true
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      ],
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        {
          "domain_id": "UP:Q9Y6K1:PWWP1",
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      ],
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      "source_date": "2026-02-18T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
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      "observed_pwwp": true
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      "kind_label": "PDB initial release",
      "date": "2026-02-18",
      "sort_date": "2026-02-18",
      "year": 2026,
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          "organism": "Homo sapiens"
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      ],
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      ],
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        {
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      "source_date": "2026-02-18T00:00:00.000+00:00",
      "date_note": "PDB deposition and initial release are separate metadata events; neither establishes publication date or historical priority.",
      "verification_level": "Frozen experimental deposition metadata with Atlas domain-coordinate mapping",
      "relevance": "Observed PWWP coordinates in this entry",
      "observed_pwwp": true
    },
    {
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      "kind_label": "PDB initial release",
      "date": "2026-02-18",
      "sort_date": "2026-02-18",
      "year": 2026,
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      ],
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        {
          "domain_id": "UP:Q9Y6K1:PWWP1",
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        {
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    },
    {
      "protein_id": "UP:P29374",
      "uniprot": "P29374",
      "gene": "ARID4A",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:P51858",
      "uniprot": "P51858",
      "gene": "HDGF",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:P52701",
      "uniprot": "P52701",
      "gene": "MSH6",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:P55201",
      "uniprot": "P55201",
      "gene": "BRPF1",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q04213",
      "uniprot": "Q04213",
      "gene": "IOC4",
      "organism": "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
    },
    {
      "protein_id": "UP:Q15326",
      "uniprot": "Q15326",
      "gene": "ZMYND11",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q15652",
      "uniprot": "Q15652",
      "gene": "JMJD1C",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q2TAK8",
      "uniprot": "Q2TAK8",
      "gene": "PWWP3A",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q49A26",
      "uniprot": "Q49A26",
      "gene": "GLYR1",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q4LE39",
      "uniprot": "Q4LE39",
      "gene": "ARID4B",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q504Y3",
      "uniprot": "Q504Y3",
      "gene": "ZCWPW2",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q586Y0",
      "uniprot": "Q586Y0",
      "gene": "28H13_90",
      "organism": "Trypanosoma brucei brucei (strain 927/4 GUTat10.1)"
    },
    {
      "protein_id": "UP:Q5H9M0",
      "uniprot": "Q5H9M0",
      "gene": "PWWP3B",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q5TGJ6",
      "uniprot": "Q5TGJ6",
      "gene": "HDGFL1",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q6NUJ5",
      "uniprot": "Q6NUJ5",
      "gene": "PWWP2B",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q7LBC6",
      "uniprot": "Q7LBC6",
      "gene": "KDM3B",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q7Z4V5",
      "uniprot": "Q7Z4V5",
      "gene": "HDGFL2",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q8R5C8",
      "uniprot": "Q8R5C8",
      "gene": "Zmynd11",
      "organism": "Mus musculus"
    },
    {
      "protein_id": "UP:Q8VHK7",
      "uniprot": "Q8VHK7",
      "gene": "Hdgf",
      "organism": "Rattus norvegicus"
    },
    {
      "protein_id": "UP:Q96L73",
      "uniprot": "Q96L73",
      "gene": "NSD1",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q96N64",
      "uniprot": "Q96N64",
      "gene": "PWWP2A",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9BZ95",
      "uniprot": "Q9BZ95",
      "gene": "NSD3",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9H0M4",
      "uniprot": "Q9H0M4",
      "gene": "ZCWPW1",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9JMG7",
      "uniprot": "Q9JMG7",
      "gene": "Hdgfl3",
      "organism": "Mus musculus"
    },
    {
      "protein_id": "UP:Q9P267",
      "uniprot": "Q9P267",
      "gene": "MBD5",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9UBC3",
      "uniprot": "Q9UBC3",
      "gene": "DNMT3B",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9ULD4",
      "uniprot": "Q9ULD4",
      "gene": "BRPF3",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9ULU4",
      "uniprot": "Q9ULU4",
      "gene": "ZMYND8",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9VAA9",
      "uniprot": "Q9VAA9",
      "gene": "Jasper",
      "organism": "Drosophila melanogaster"
    },
    {
      "protein_id": "UP:Q9Y3E1",
      "uniprot": "Q9Y3E1",
      "gene": "HDGFL3",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9Y4C1",
      "uniprot": "Q9Y4C1",
      "gene": "KDM3A",
      "organism": "Homo sapiens"
    },
    {
      "protein_id": "UP:Q9Y6K1",
      "uniprot": "Q9Y6K1",
      "gene": "DNMT3A",
      "organism": "Homo sapiens"
    }
  ],
  "feature_exclusions": []
}
