PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Experimental structure

7MDN

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

Co-Crystals PWWP coordinates observed X-RAY DIFFRACTION

Original coordinates

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PDB deposition
7MDN Deposited model
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Original coordinates are available from a locally verified historical archive or the bundled source and load on request.

Coordinate coverage

Mapped chains

8 chain / domain rows

Label and author chain identifiers are kept separately. Observed Cα counts refer to each mapped annotation core.

ProteinLabel chainAuthor chainDomainObserved Cα / coreObserved substitutions
NSD2A["A"]UP:O96028:PWWP161 / 650
NSD2B["B"]UP:O96028:PWWP161 / 650
NSD2C["C"]UP:O96028:PWWP161 / 650
NSD2D["D"]UP:O96028:PWWP162 / 650
NSD2E["E"]UP:O96028:PWWP162 / 650
NSD2F["F"]UP:O96028:PWWP161 / 650
NSD2G["G"]UP:O96028:PWWP161 / 650
NSD2H["H"]UP:O96028:PWWP161 / 650

Chemical identity

Chemical components and interpretation

3 component records
CCDNameRoleFull InChIKey
Y6V~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamideexperimentally studied ligand
functional		XPHOPAPMJBSLFN-UHFFFAOYSA-N
UNXUNKNOWN ATOM OR IONunknown chemical component
unknown		Unresolved
HOHWATERsolvent
incidental		XLYOFNOQVPJJNP-UHFFFAOYSA-N

Geometry, with defined scope

Independent contact evidence

Inspect 20 retained contact records
CCD / instanceProtein chainContact classMinimum core / broader domain distance Å
UNX · JNSD2 · Abroader Pfam PWWP contact10.1 / 3.38
UNX · ONSD2 · Dnative annotation core contact3.11 / 3.11
UNX · ONSD2 · Enative annotation core contact2.9 / 2.9
UNX · JNSD2 · Fnative annotation core contact4.5 / 4.5
Y6V · INSD2 · Anative annotation core contact2.94 / 2.94
Y6V · PNSD2 · Anative annotation core contact3.95 / 3.49
Y6V · KNSD2 · Bnative annotation core contact2.93 / 2.93
Y6V · NNSD2 · Bnative annotation core contact3.86 / 3.5
Y6V · KNSD2 · Cnative annotation core contact3.9 / 3.46
Y6V · LNSD2 · Cnative annotation core contact2.93 / 2.93
Y6V · LNSD2 · Dnative annotation core contact3.79 / 3.52
Y6V · MNSD2 · Dnative annotation core contact2.82 / 2.82
Y6V · MNSD2 · Enative annotation core contact3.89 / 3.55
Y6V · NNSD2 · Enative annotation core contact2.91 / 2.91
Y6V · PNSD2 · Fnative annotation core contact2.93 / 2.93
Y6V · QNSD2 · Fnative annotation core contact3.88 / 3.49
Y6V · QNSD2 · Gnative annotation core contact2.91 / 2.91
Y6V · RNSD2 · Gnative annotation core contact3.92 / 3.55
Y6V · INSD2 · Hnative annotation core contact3.84 / 3.52
Y6V · RNSD2 · Hnative annotation core contact2.9 / 2.9

Biological partners

No curated macromolecular partner record.

Source interpretation

Focused scientific audit

Full review queue

retain with stated interpretation/caveats. Co-crystal supported; all eight NSD2 chains have partial core loops. Preserve per-chain coverage and UNX warning.