Evidence explorer

Structure and assay evidence

Follow NSD2 from a deposited contact to its preparation, assay and primary source.

Complete query JSON

82exact contact–assay rows

15assay rows without an exact contact link

11preparation records

NSD2 · Structure-linked observations

Exact identity links to deposited contacts

82 rows

82 rows join a geometric contact to an assay on the same native target/domain. Multiple rows may describe the same ligand, structure or measurement. Chain-contact rank is geometric and is not a biological-site assignment.

PDB and chain	Domain / component	Contact evidence	Preparation and measurement	Assay construct and source
6UE6 Chain C	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.07 Å Broader 3.07 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain C	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.07 Å Broader 3.07 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain D	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.72 Å Broader 3.59 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain D	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.72 Å Broader 3.59 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain A	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.06 Å Broader 3.06 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain A	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.06 Å Broader 3.06 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain B	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.69 Å Broader 3.63 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain B	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.69 Å Broader 3.63 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain A	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 4.18 Å Broader 3.37 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain A	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 4.18 Å Broader 3.37 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain D	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.05 Å Broader 3.05 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain D	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.05 Å Broader 3.05 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain E	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.81 Å Broader 3.51 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain E	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.81 Å Broader 3.51 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain H	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.04 Å Broader 3.04 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain H	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.04 Å Broader 3.04 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain E	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.03 Å Broader 3.03 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain E	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.03 Å Broader 3.03 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain F	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.7 Å Broader 3.43 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain F	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.7 Å Broader 3.43 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain B	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.01 Å Broader 3.01 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain B	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.01 Å Broader 3.01 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain C	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.94 Å Broader 3.45 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain C	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.94 Å Broader 3.45 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain F	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.07 Å Broader 3.07 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain F	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.07 Å Broader 3.07 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain G	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.87 Å Broader 3.57 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain G	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.87 Å Broader 3.57 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain G	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.04 Å Broader 3.04 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain G	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.04 Å Broader 3.04 Å Distance rank 1; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain H	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.91 Å Broader 3.54 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 7.0 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6UE6 Chain H	PWWP1 · Q5D INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	native annotation core contact Core 3.91 Å Broader 3.54 Å Distance rank 2; multiple chains contact this component	MR837 (3f) SPR Kd = 3.4 µM Preparation identity	Uncurated boundaries Primary evidence Full assay buffer, temperature and incubation metadata not transcribed; null means uncurated, not absent. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain A	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.86 Å Broader 2.86 Å Distance rank 1	UNC6934 SPR Kd = 91.0 nM Preparation identity	208–368 Primary evidence SPR temperature and exact uncertainty definition are not specified in the inspected assay-specific source. Triplicate experiments reported. Preparation/assay construct differs from crystallization 211–350. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain A	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.86 Å Broader 2.86 Å Distance rank 1	UNC6934 AlphaScreen IC50 = 104.0 nM Preparation identity	208–368 Primary evidence 23°C is the antagonist preincubation temperature, not a verified readout temperature. Final DMSO fraction and SD-versus-SEM definition for ±13 nM are not explicit in the inspected assay-specific text. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain A	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.86 Å Broader 2.86 Å Distance rank 1	UNC6934 NanoBRET PPI half-response = 1.23 µM Preparation identity	Uncurated boundaries Primary evidence NanoLuc construct boundaries, readout temperature and SD-versus-SEM are not explicit in the inspected source. Results say EC50 while Discussion says IC50; neutral half-response label retained. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain A	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.86 Å Broader 2.86 Å Distance rank 1	UNC6934 SPR Kd = 0.24 µM Preparation identity	208–368 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain A	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.86 Å Broader 2.86 Å Distance rank 1	UNC6934 SPR Kd = 1.33 µM Preparation identity	211–350 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain B	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.88 Å Distance rank 1	UNC6934 SPR Kd = 91.0 nM Preparation identity	208–368 Primary evidence SPR temperature and exact uncertainty definition are not specified in the inspected assay-specific source. Triplicate experiments reported. Preparation/assay construct differs from crystallization 211–350. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain B	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.88 Å Distance rank 1	UNC6934 AlphaScreen IC50 = 104.0 nM Preparation identity	208–368 Primary evidence 23°C is the antagonist preincubation temperature, not a verified readout temperature. Final DMSO fraction and SD-versus-SEM definition for ±13 nM are not explicit in the inspected assay-specific text. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain B	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.88 Å Distance rank 1	UNC6934 NanoBRET PPI half-response = 1.23 µM Preparation identity	Uncurated boundaries Primary evidence NanoLuc construct boundaries, readout temperature and SD-versus-SEM are not explicit in the inspected source. Results say EC50 while Discussion says IC50; neutral half-response label retained. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain B	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.88 Å Distance rank 1	UNC6934 SPR Kd = 0.24 µM Preparation identity	208–368 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain B	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.88 Å Distance rank 1	UNC6934 SPR Kd = 1.33 µM Preparation identity	211–350 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain C	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.89 Å Broader 2.79 Å Distance rank 1	UNC6934 SPR Kd = 91.0 nM Preparation identity	208–368 Primary evidence SPR temperature and exact uncertainty definition are not specified in the inspected assay-specific source. Triplicate experiments reported. Preparation/assay construct differs from crystallization 211–350. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain C	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.89 Å Broader 2.79 Å Distance rank 1	UNC6934 AlphaScreen IC50 = 104.0 nM Preparation identity	208–368 Primary evidence 23°C is the antagonist preincubation temperature, not a verified readout temperature. Final DMSO fraction and SD-versus-SEM definition for ±13 nM are not explicit in the inspected assay-specific text. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain C	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.89 Å Broader 2.79 Å Distance rank 1	UNC6934 NanoBRET PPI half-response = 1.23 µM Preparation identity	Uncurated boundaries Primary evidence NanoLuc construct boundaries, readout temperature and SD-versus-SEM are not explicit in the inspected source. Results say EC50 while Discussion says IC50; neutral half-response label retained. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain C	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.89 Å Broader 2.79 Å Distance rank 1	UNC6934 SPR Kd = 0.24 µM Preparation identity	208–368 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
6XCG Chain C	PWWP1 · V01 INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	native annotation core contact Core 2.89 Å Broader 2.79 Å Distance rank 1	UNC6934 SPR Kd = 1.33 µM Preparation identity	211–350 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain A	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3 Å Broader 2.99 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain H	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.86 Å Broader 3.5 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain B	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3 Å Broader 2.96 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain C	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.94 Å Broader 3.49 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain C	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3 Å Broader 3 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain D	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.8 Å Broader 3.53 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain D	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.87 Å Broader 2.87 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain E	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.92 Å Broader 3.58 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain B	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.89 Å Broader 3.47 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain E	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.97 Å Broader 2.97 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain A	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.95 Å Broader 3.48 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain F	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.99 Å Broader 2.99 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain F	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.92 Å Broader 3.49 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain G	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.96 Å Broader 2.96 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain G	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.91 Å Broader 3.54 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7LMT Chain H	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.97 Å Broader 2.97 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain A	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.94 Å Broader 2.94 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain H	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.84 Å Broader 3.52 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain B	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.93 Å Broader 2.93 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain C	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.9 Å Broader 3.46 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain C	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.93 Å Broader 2.93 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain D	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.79 Å Broader 3.52 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain D	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.82 Å Broader 2.82 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain E	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.89 Å Broader 3.55 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain B	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.86 Å Broader 3.5 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain E	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.91 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain A	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.95 Å Broader 3.49 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain F	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.93 Å Broader 2.93 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain F	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.88 Å Broader 3.49 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain G	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.91 Å Broader 2.91 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain G	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 3.92 Å Broader 3.55 Å Distance rank 2; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
7MDN Chain H	PWWP1 · Y6V INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	native annotation core contact Core 2.9 Å Broader 2.9 Å Distance rank 1; multiple chains contact this component	MRT866 SPR Kd = 349.0 nM Preparation identity	Uncurated boundaries Primary evidence 349 ± 19 nM verified in Results; MRT866-specific SPR construct/protocol, replicate definition and uncertainty statistic remain unresolved. Crystallography 211–350 is not assigned as the binding-assay construct. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
9FOE Chain A	PWWP1 · A1IEF INCHIKEY:HHACEXLLNHJLFT-INIZCTEOSA-N	native annotation core contact Core 3.12 Å Broader 3.12 Å Distance rank 1	compound 7 (Collie 2025) SPR Kd = 0.15 µM Preparation identity	208–368 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
9FOE Chain A	PWWP1 · A1IEF INCHIKEY:HHACEXLLNHJLFT-INIZCTEOSA-N	native annotation core contact Core 3.12 Å Broader 3.12 Å Distance rank 1	compound 7 (Collie 2025) SPR Kd = 0.76 µM Preparation identity	211–350 Primary evidence Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed
9FOE Chain A	PWWP1 · A1IEF INCHIKEY:HHACEXLLNHJLFT-INIZCTEOSA-N	native annotation core contact Core 3.12 Å Broader 3.12 Å Distance rank 1	compound 7 (Collie 2025) HTRF displacement IC50 = 0.21 µM Preparation identity	208–368 Primary evidence HTRF full conditions are referenced to Carlino et al. 2024 DOI 10.1021/acs.jmedchem.4c00215. Its main protocol remains inaccessible after official repository checks. The actual supplement was inspected but contains no HTRF protocol. Table 1 reports SEM; independence level of HTRF replicates is not specified. Link interpretation same exact chemical identity and native domain; construct equivalence not assumed

NSD2 · Additional published evidence

Assays without an exact contact link

15 records

These observations remain usable at their stated preparation and assay level. A negative result, missing co-crystal, unresolved preparation or mixed stereochemistry can prevent an exact contact link.

Preparation	Result	Identity status	Source
HS13	Quantitative assay verification pending No source-checked numeric value	paper label exact identity unresolved	PMID:42442058 Primary abstract reports Kd 8.33 µM and C294 covalency; full assay method, construct, uncertainty and exact chemical identity not verified. Main value remains null.
UNC7145	SPR no appreciable binding No source-checked numeric value	paper label exact identity unresolved	PMID:34782742 Primary-source concentration discrepancy: Results report no appreciable binding up to 20 uM, but SPR Methods state 2 uM as highest concentration. Neither is converted into a Kd bound; human source review required.
compound 11 (Collie 2025)	SPR Kd = 1.02 µM ± 0.19	assayed stereoisomeric mixture not single chemical identity	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 11 (Collie 2025)	SPR Kd = 2.3 µM ± 0.31	assayed stereoisomeric mixture not single chemical identity	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 12 (Collie 2025)	SPR Kd = 1.47 µM ± 0.13	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 12 (Collie 2025)	SPR Kd = 2.8 µM ± 0.31	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 12 (Collie 2025)	HTRF displacement IC50 = 2.49 µM ± 0.06	paper label exact identity unresolved	PMID:40959233 HTRF full conditions are referenced to Carlino et al. 2024 DOI 10.1021/acs.jmedchem.4c00215. Its main protocol remains inaccessible after official repository checks. The actual supplement was inspected but contains no HTRF protocol. Table 1 reports SEM; independence level of HTRF replicates is not specified.
compound 13 (Collie 2025)	SPR Kd = 0.75 µM ± 0.04	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 13 (Collie 2025)	SPR Kd = 1.52 µM ± 0.05	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 13 (Collie 2025)	HTRF displacement IC50 = 1.31 µM ± 0.06	paper label exact identity unresolved	PMID:40959233 HTRF full conditions are referenced to Carlino et al. 2024 DOI 10.1021/acs.jmedchem.4c00215. Its main protocol remains inaccessible after official repository checks. The actual supplement was inspected but contains no HTRF protocol. Table 1 reports SEM; independence level of HTRF replicates is not specified.
compound 5 (Collie 2025)	SPR Kd = 0.16 µM ± 0.03	assayed stereoisomeric mixture not single chemical identity	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 5 (Collie 2025)	SPR Kd = 0.92 µM ± 0.03	assayed stereoisomeric mixture not single chemical identity	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 6 (Collie 2025)	SPR Kd = 0.71 µM ± 0.09	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 6 (Collie 2025)	SPR Kd = 5.83 µM ± 0.64	paper label exact identity unresolved	PMID:40959233 Assay-specific buffer and temperature verified from SI page 9; tag/construct from Table S2. Exact per-row kinetic-versus-steady-state fit choice and exact n beyond table footnote not specified. Chemical preparation identity remains as curated.
compound 6 (Collie 2025)	HTRF displacement IC50 = 1.24 µM ± 0.08	paper label exact identity unresolved	PMID:40959233 HTRF full conditions are referenced to Carlino et al. 2024 DOI 10.1021/acs.jmedchem.4c00215. Its main protocol remains inaccessible after official repository checks. The actual supplement was inspected but contains no HTRF protocol. Table 1 reports SEM; independence level of HTRF replicates is not specified.

NSD2 · Identity scope

Preparation identities and modeled candidates

11 records

Preparation	Identity status	Exact identity	Modeled candidates
HS13	paper label exact identity unresolved	Unresolved at exact-identity level	[] Complete deposited identity retained; no connectivity-only or name-only merge.
MR837 (3f)	exact single CCD identity	INCHIKEY:WYAGGMZTARRIDX-UHFFFAOYSA-N	[] Complete deposited identity retained; no connectivity-only or name-only merge.
MRT866	exact single CCD identity	INCHIKEY:XPHOPAPMJBSLFN-UHFFFAOYSA-N	[] Complete deposited identity retained; no connectivity-only or name-only merge.
UNC6934	exact single CCD identity	INCHIKEY:KOZGEDUWAQFVAV-UHFFFAOYSA-N	[] Complete deposited identity retained; no connectivity-only or name-only merge.
UNC7145	paper label exact identity unresolved	Unresolved at exact-identity level	[] Complete deposited identity retained; no connectivity-only or name-only merge.
compound 11 (Collie 2025)	assayed stereoisomeric mixture not single chemical identity	Unresolved at exact-identity level	["INCHIKEY:FPDVOQXTUVFQHW-KBPBESRZSA-N", "INCHIKEY:FPDVOQXTUVFQHW-KGLIPLIRSA-N"] Assayed diastereomeric preparation: pyrrolidine 2S fixed and sulfolane center racemic in the SI name. A1IEG/A1IFS are modeled candidates in 9FOC; mixture affinity is not assigned to either pure stereoisomer. Composition ratio and fraction-to-CCD assignment remain unresolved.
compound 12 (Collie 2025)	paper label exact identity unresolved	Unresolved at exact-identity level	[] Separated compound 11 fraction labelled isomer 1; retention time 7.1 min, reported dr 98.84:1.16. Absolute sulfolane assignment and exact CCD mapping remain unresolved; no affinity transfer from compound 11.
compound 13 (Collie 2025)	paper label exact identity unresolved	Unresolved at exact-identity level	[] Separated compound 11 fraction labelled isomer 2; retention time 8.2 min, reported dr 97.10:2.90. Absolute sulfolane assignment and exact CCD mapping remain unresolved; no affinity transfer from compound 11.
compound 5 (Collie 2025)	assayed stereoisomeric mixture not single chemical identity	Unresolved at exact-identity level	[] Racemate 5 is distinct from separated enantiomers 6 and 7.
compound 6 (Collie 2025)	paper label exact identity unresolved	Unresolved at exact-identity level	[] Complete deposited identity retained; no connectivity-only or name-only merge.
compound 7 (Collie 2025)	exact single CCD identity	INCHIKEY:HHACEXLLNHJLFT-INIZCTEOSA-N	[] Complete deposited identity retained; no connectivity-only or name-only merge.