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Proteins · UniProt / Atlas

NSD2

Histone-lysine N-methyltransferase NSD2 · Homo sapiens · O96028

Domains · Domain mapping

NSD2 · PWWP1

Residues 222–286 · UP:O96028:PWWP1

Domains · Domain mapping

NSD2 · PWWP2

Residues 880–942 · UP:O96028:PWWP2

Bioactivity · Recorded assay

compound 11 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 11 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 12 (Collie 2025) · HTRF displacement IC50

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 12 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 12 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 13 (Collie 2025) · HTRF displacement IC50

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 13 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 13 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 5 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 5 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 6 (Collie 2025) · HTRF displacement IC50

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 6 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 6 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 7 (Collie 2025) · HTRF displacement IC50

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 7 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

compound 7 (Collie 2025) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

HS13 · Quantitative assay verification pending

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

MR837 (3f) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

MR837 (3f) · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

MRT866 · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC6934 · AlphaScreen IC50

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC6934 · NanoBRET PPI half-response

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC6934 · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC6934 · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC6934 · SPR Kd

NSD2 · recorded experimental assay

Bioactivity · Recorded assay

UNC7145 · SPR no appreciable binding

NSD2 · recorded experimental assay

Structures · RCSB PDB

29HG · Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10088

Experimental structure · PDB 29HG

Structures · RCSB PDB

29HH · Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2, UNC10088 and Bach1

Experimental structure · PDB 29HH

Structures · RCSB PDB

29HI · Cryo-EM structure of the CUL1-RBX1-SKP1-FBXO22 SCF ubiquition ligase in complex with NSD2 via UNC10415667

Experimental structure · PDB 29HI

Structures · RCSB PDB

6UE6 · PWWP1 domain of NSD2 in complex with MR837

Experimental structure · PDB 6UE6

Structures · RCSB PDB

6XCG · Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934

Experimental structure · PDB 6XCG

Structures · RCSB PDB

7CRO · NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP

Experimental structure · PDB 7CRO

Structures · RCSB PDB

7LMT · Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

Experimental structure · PDB 7LMT

Structures · RCSB PDB

7MDN · Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

Experimental structure · PDB 7MDN

Structures · RCSB PDB

7VLN · NSD2-PWWP1 domain bound with an imidazol-5-yl benzonitrile compound

Experimental structure · PDB 7VLN

Structures · RCSB PDB

9EXW · Crystal structure of the PWWP1 domain of NSD2 bound by compound 17.

Experimental structure · PDB 9EXW

Structures · RCSB PDB

9EXX · Crystal structure of the PWWP1 domain of NSD2 bound by compound 18.

Experimental structure · PDB 9EXX

Structures · RCSB PDB

9EXY · Crystal structure of the PWWP1 domain of NSD2 bound by compound 34.

Experimental structure · PDB 9EXY

Structures · RCSB PDB

9FOC · Crystal structure of the PWWP1 domain of NSD2 bound by compound 11.

Experimental structure · PDB 9FOC

Structures · RCSB PDB

9FOE · Crystal structure of the PWWP1 domain of NSD2 bound by compound 7.

Experimental structure · PDB 9FOE

Structures · RCSB PDB

9KN9 · NSD2-PWWP1 domain bound with compound 1.

Experimental structure · PDB 9KN9

Structures · RCSB PDB

9KNA · NSD2-PWWP1 domain bound with compound 6

Experimental structure · PDB 9KNA

Structures · RCSB PDB

9KNB · NSD2-PWWP1 domain bound with compound 9

Experimental structure · PDB 9KNB

Structures · RCSB PDB

9Y60 · Crystal structure of NSD2 PWWP1 domain in complex with (6R)-6-(3,5-dichlorophenyl)morpholin-3-one (ligand 2)

Experimental structure · PDB 9Y60

Structures · RCSB PDB

9Y61 · Cryo-EM structure of ternary complex NSD2-PWWP1:CRBN:DDB1 in complex with NSD2-LDD, an LDD degrader

Experimental structure · PDB 9Y61