Studied + deposited research ligandReported probe
BI-9321
NSD3
SPR Kd= 166 ± 3 nMOne source observation · PMID:31285596
3 matching observations1 PWWP research-ligand PDB entries
Scientific evidence classification · Phase 6A preserved + Phase 6B additions
PWWP Compounds
& Bioactivity
Explore experimentally studied preparations separately from deposited research ligands, buffers, ions and unresolved chemical evidence. Every role is source- and target-context specific.
Different denominators · 26 October 2026
38studied preparation profiles · 26 baseline + 12 new
109profiles with PWWP research-ligand geometry
93source assay / association observations · 80 baseline + 13 new
Combined Phase 6A + Phase 6B denominators. These groups overlap; the 109 structurally source-tagged research ligands are unchanged. Deposited components and reagents are not automatically biochemical binders.
Evidence classification · exact source records
28 matching profiles
41 matching assay / association observations. Counts here are profiles, not unique assay events or deposited ligand instances; views overlap.
Identity, assays & sources
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 1 (de Freitas 2021)
NSD2
SPR Kd= 41 ± 8 µMOne source observation · PMID:33522809
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 11 (Collie 2025)
NSD2NSD3
SPR Kd= 1.02 ± 0.19 µMOne source observation · PMID:40959233
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 12 (Collie 2025)
NSD2NSD3
SPR Kd= 1.47 ± 0.13 µMOne source observation · PMID:40959233
4 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 13 (Collie 2025)
NSD2NSD3
SPR Kd= 0.75 ± 0.04 µMOne source observation · PMID:40959233
4 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 5 (Collie 2025)
NSD2NSD3
SPR Kd= 0.16 ± 0.03 µMOne source observation · PMID:40959233
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 6 (Collie 2025)
NSD2NSD3
SPR Kd= 0.71 ± 0.09 µMOne source observation · PMID:40959233
4 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
H4K20me3 peptide / trimethyllysine monomer
HDGFL2
No source-curated measured assay in this context. Structural evidence is shown separately.
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
HS13
NSD2
Source verification is pending.
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligandExperiment-specific control
MS9715N
NSD3
ITC Kd= 1.62 ± 0.33 µMOne source observation · PMID:34469831
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
NbH10
HDGFL2PSIP1
SPR apparent Kd= 94.4 ± 9.1 nMOne source observation · PMID:42194065
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
UNC7753
NSD2
In-cell western degradation= 1.2 ± 0.3 µMOne source observation · PMID:36976643
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
UNC8269
NSD2
SPR Kd= 36 ± 21 nMOne source observation · PMID:38965384
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
UNC8325
NSD2
SPR Kd= 41 ± 19 nMOne source observation · PMID:38965384
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligandExperiment-specific control
UNC8587
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligandExperiment-specific control
UNC8884
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
(1R)-N-methyl-1-(pyridin-4-yl)propan-1-amine
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
(2R)-1-(cyclohexylamino)propan-2-ol
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
(2S)-N-(5-ethyl-1,3,4-thiadiazol-2-yl)oxolane-2-carboxamide
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
(3R)-N-methyl-1-(pyridazin-3-yl)piperidin-3-amine
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
2-[(2S)-2-methylpiperidin-1-yl]ethan-1-amine
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
4-[[cyclopropyl-[(~{Z})-2-methyl-4-(5-oxidanylidene-2~{H}-1,4-oxazin-3-yl)but-3-enoyl]amino]methyl]-~{N}-[3-[2-[[4-(hydroxymethyl)phenyl]carbonyl-methyl-amino]ethyl]phenyl]benzamide
NSD2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
[(3S)-1-(propan-2-yl)piperidin-3-yl]methanol
HDGFL2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
Identity / evidence review pending
CYSTEINESULFONIC ACID
BRD1
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations0 PWWP research-ligand PDB entries
Identity / evidence review pending
N-TRIMETHYLLYSINE
BRPF1DNMT3BHDGFL2HDGFL3Zmynd11
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations0 PWWP research-ligand PDB entries
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
UNKNOWN ATOM OR ION
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
Unknown ligand
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Identity / evidence review pending
ZINC ION
BRPF3ZMYND11ZMYND8Zmynd11
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations0 PWWP research-ligand PDB entries