PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Phase 6B · provenance and decision ledger

Discovery-candidate triage

Source review outcomes are not automatically accepted assays or biological negatives. Original identifiers and frozen evidence remain intact.

Accepted observations

150 / 150 records

CSV download (selected status)
Record IDSource / evidenceReview outcomeOriginal data & limitations
CAND:BINDINGDB:O75475BindingDB
Source link		relevant but unresolved
not_individually_verified

Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:BINDINGDB:O75475",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 2,
  "original_record_sha256": "6f13c8d7b566b475034668d7d2d99cf70306288fca0167ae26aff34b066e4858",
  "original_status": "target_level_discovery_only",
  "original_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=O75475\u0026response=application/json",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "protein_uniprot": "O75475",
  "publication": null,
  "source_kind": "BindingDB",
  "source_row_count": 7
}
CAND:BINDINGDB:O96028BindingDB
Source link		relevant but unresolved
not_individually_verified

Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:BINDINGDB:O96028",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 2,
  "original_record_sha256": "fd4be2e295f74a05ee866a682f867a84828c39afed7f863a27324dad9e1d873f",
  "original_status": "target_level_discovery_only",
  "original_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=O96028\u0026response=application/json",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "protein_uniprot": "O96028",
  "publication": null,
  "source_kind": "BindingDB",
  "source_row_count": 92
}
CAND:BINDINGDB:Q7Z4V5BindingDB
Source link		relevant but unresolved
not_individually_verified

Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:BINDINGDB:Q7Z4V5",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 2,
  "original_record_sha256": "7a6b9709a5a425e6dc88f4f6b652c62652d3455d6d3ad7ce594eb689d24cff28",
  "original_status": "target_level_discovery_only",
  "original_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=Q7Z4V5\u0026response=application/json",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "protein_uniprot": "Q7Z4V5",
  "publication": null,
  "source_kind": "BindingDB",
  "source_row_count": 0
}
CAND:BINDINGDB:Q9BZ95BindingDB
Source link		relevant but unresolved
not_individually_verified

Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:BINDINGDB:Q9BZ95",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 2,
  "original_record_sha256": "421cb94c694de4ac80ee4f113e9444008c437a0185fb6cd0a6e1b77f88666447",
  "original_status": "target_level_discovery_only",
  "original_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=Q9BZ95\u0026response=application/json",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Accession-level query receipt only, not an independent molecular observation; possible SET-domain confounding",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "protein_uniprot": "Q9BZ95",
  "publication": null,
  "source_kind": "BindingDB",
  "source_row_count": 5
}
CAND:CHEMBL:25865040ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865040",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4778517",
  "molecule_inchikey": "WOAOENGFAAUUGT-UHFFFAOYSA-N",
  "original_activity_id": 25865040,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "454f87213b43393532143303eb1fbc8cc23aa496fdc5e15377c4dddce78d643b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865040",
  "original_value": "25118.86",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865041ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865041",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4758943",
  "molecule_inchikey": "WYAGGMZTARRIDX-UHFFFAOYSA-N",
  "original_activity_id": 25865041,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "de178d8aab4f3e16be0a2c9e3c2faa8399dbf3458a5cf729c08bbdadfdb89a07",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865041",
  "original_value": "2511.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865042ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865042",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865042,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "67a83fb057f647e1746e18c25790c8afe99f6cc0becc9e4aff097a02a08424fb",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865042",
  "original_value": "251.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865043ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865043",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5563959",
  "molecule_inchikey": "ABIXPIGGPYBTDD-UHFFFAOYSA-N",
  "original_activity_id": 25865043,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "13be8ee2da1281d183a547d4e7216436e3455c0498474b93eb9d0e8ba2f06c15",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865043",
  "original_value": "12589.25",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865044ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865044",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562861",
  "molecule_inchikey": "NMBPINFRTFCTEF-UHFFFAOYSA-N",
  "original_activity_id": 25865044,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "06c4d83e6cdd1c76416e97b8b707ee932bda0b4f98c5e2f724d29a7b0bdcecb8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865044",
  "original_value": "501.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865045ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865045",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562153",
  "molecule_inchikey": "ULLWFQAIKLJZRX-UHFFFAOYSA-N",
  "original_activity_id": 25865045,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "9b295a019c53256bf5074d2f739df92b6a600db24d85cef99fda72315ca40024",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865045",
  "original_value": "50.12",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865046ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865046",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556655",
  "molecule_inchikey": "KEGFMQLKKFOVDX-UHFFFAOYSA-N",
  "original_activity_id": 25865046,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "3b503060dbef953467997a36d1e320bb2b5aa01e7139b4abde50e8c38dba47c7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865046",
  "original_value": "3162.28",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865047ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865047",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560105",
  "molecule_inchikey": "MRMUTHUMMVEAMF-UHFFFAOYSA-N",
  "original_activity_id": 25865047,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "595725f17203672287320bb5621ddbab80513b42f67414f52d9b8119105bf2c9",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865047",
  "original_value": "630.96",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865048ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865048",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557539",
  "molecule_inchikey": "MZLIUXKMCHXQNU-UHFFFAOYSA-N",
  "original_activity_id": 25865048,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "ef7b31bb1472f959fb5833fe4ab3e96f06859b971e8cb1311329d1a147eca0a7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865048",
  "original_value": "158.49",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865049ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865049",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067693",
  "molecule_inchikey": "VEWYIWGYIVHOBN-UHFFFAOYSA-N",
  "original_activity_id": 25865049,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "07c4180276fccd9ed21beb02069e1774655ed975140c3c76b157ef70366725d8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865049",
  "original_value": "158.49",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865050ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865050",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5518061",
  "molecule_inchikey": "NQERJHKXGVIGAD-UHFFFAOYSA-N",
  "original_activity_id": 25865050,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "bd87a781261b4fba53c1a7ad37cb3757590c8ef4c63584ea1d5553d98b72fb90",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865050",
  "original_value": "10000.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865051ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865051",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067694",
  "molecule_inchikey": "GFIQDMKDUFQAHX-UHFFFAOYSA-N",
  "original_activity_id": 25865051,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "2b087a94e5309b8511abe417d116c9aa7664eb178f326ea35f5b77f140d5aeb8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865051",
  "original_value": "630.96",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865052ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865052",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5555145",
  "molecule_inchikey": "BCEHCNGIJHAHTP-UHFFFAOYSA-N",
  "original_activity_id": 25865052,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "91c11ab034581520380e6451701287786f1c7ac85f979415a88ea376868e0e70",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865052",
  "original_value": "501.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865053ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865053",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542909",
  "molecule_inchikey": "CDZHONALNGXILP-UHFFFAOYSA-N",
  "original_activity_id": 25865053,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "cf4db4d92cd0f7c491166b59556ed3902f688363871eb561de632f7f6987a3de",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865053",
  "original_value": "125.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865054ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865054",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517868",
  "molecule_inchikey": "DXBREQYPXPKCLM-UHFFFAOYSA-N",
  "original_activity_id": 25865054,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "dcf9d856703903715200711ad61ac48b3df171ff75b20f5316cff3189138c670",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865054",
  "original_value": "79.43",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865055ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865055",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562340",
  "molecule_inchikey": "ZBWHBKUMYLPCMF-UHFFFAOYSA-N",
  "original_activity_id": 25865055,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "adc49b925ad7133c02d442a87002e1fb74dc82804249565d8c03e22ed27302b6",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865055",
  "original_value": "19.95",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865056ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865056",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559177",
  "molecule_inchikey": "APUAYMXUHLOPLQ-UHFFFAOYSA-N",
  "original_activity_id": 25865056,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "2a80bea866764df5f24e05df34b204324290426837ae85a7fb94cb8a335e55a2",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865056",
  "original_value": "63.1",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865057ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865057",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5562663",
  "molecule_inchikey": "IRSPYYYZACJWSE-UHFFFAOYSA-N",
  "original_activity_id": 25865057,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "c2f32e5282233ce87e73333278f5b03576ec020d26c8bad5b94fa97328b99ca2",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865057",
  "original_value": "199.53",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865058ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865058",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557662",
  "molecule_inchikey": "CAXXUAPKMOVWIN-UHFFFAOYSA-N",
  "original_activity_id": 25865058,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "511fc3d261486de3f7280bd205f3b92ee7eee749ac8873d6abd272274dd4485a",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865058",
  "original_value": "1.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865059ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865059",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5565515",
  "molecule_inchikey": "ZEZCOKVXQVYETH-UHFFFAOYSA-N",
  "original_activity_id": 25865059,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "e8f1428c13792750579b2e7b247f2a609be48df463ca2db4dd015e74f1e76399",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865059",
  "original_value": "398.11",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865060ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865060",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5561556",
  "molecule_inchikey": "CUALDSZSVUZWJN-UHFFFAOYSA-N",
  "original_activity_id": 25865060,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "3d46661b2a567a0482b027538adea82ac9e1b34c2cc2982a5f0367da9b1aaf72",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865060",
  "original_value": "3981.07",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865061ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865061",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560960",
  "molecule_inchikey": "OUOZZTLCSMEGMB-GOSISDBHSA-N",
  "original_activity_id": 25865061,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "9465d2da516cb14b3e158cb04506ccdcd213bc20b4bc5e3ca3c630fb47e0add7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865061",
  "original_value": "63.1",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865062ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865062",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532580",
  "molecule_inchikey": "HUWXNQUPNJTKDZ-UHFFFAOYSA-N",
  "original_activity_id": 25865062,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "6738937d1c9f44d47d2171ff900b0041a3469835cbdfb7ca542e78b462b21212",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865062",
  "original_value": "398.11",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865063ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865063",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562333",
  "molecule_inchikey": "ICIKTJUZMIFHRD-QGZVFWFLSA-N",
  "original_activity_id": 25865063,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "02771306b0f7168cd352f88f6e92aff81cefabd848ca48a63a3e736979a44cc7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865063",
  "original_value": "50.12",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865064ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865064",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532365",
  "molecule_inchikey": "NGQMSCPPMHZUPJ-UHFFFAOYSA-N",
  "original_activity_id": 25865064,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "9959dc8f5af48ce0656251f382b07099c7276db77215032a643163a36820b98a",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865064",
  "original_value": "630.96",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865065ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865065",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5527939",
  "molecule_inchikey": "IHCNPLSAPCQDEB-LJQANCHMSA-N",
  "original_activity_id": 25865065,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "00261dbe43ca012d78c5efb7ef83ac9d3d159f50716d5d62f040505d8e584577",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865065",
  "original_value": "31.62",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865066ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865066",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542933",
  "molecule_inchikey": "PZQHTJPFTVSYKN-GOSISDBHSA-N",
  "original_activity_id": 25865066,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "8177718fe5b3f356caf7029eb04b8b4e623bc688718591861afcc77dbe6e559b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865066",
  "original_value": "31.62",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865067ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865067",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532583",
  "molecule_inchikey": "KTVJINSMSOLPAV-UHFFFAOYSA-N",
  "original_activity_id": 25865067,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "e41c8078046bf1a71af9a7e1c68602fc01f22d623704fc091973965b91582244",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865067",
  "original_value": "251.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865068ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865068",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517660",
  "molecule_inchikey": "YZOCGUCOBQCCGW-SFHVURJKSA-N",
  "original_activity_id": 25865068,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "ac3b3bd1b4a4daba6090ee455a32bd5b2e6d943c361bb21f8a28f80b42711add",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865068",
  "original_value": "50.12",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865069ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865069",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556330",
  "molecule_inchikey": "YZOCGUCOBQCCGW-GOSISDBHSA-N",
  "original_activity_id": 25865069,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "625c409d3e81ba741964fa46c446ac6aee6a3efcafc6193192fd14635520069f",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865069",
  "original_value": "100.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865070ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865070",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556168",
  "molecule_inchikey": "PTDHIMCHWIFQJG-UHFFFAOYSA-N",
  "original_activity_id": 25865070,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "3c864d1f15f91e3ac5e902202f4c2c1f55ac9e280f489e125832bb8fd2e4ba3f",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865070",
  "original_value": "199.53",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865071ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865071",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542423",
  "molecule_inchikey": "ATEQBDBQCUHGAY-UHFFFAOYSA-N",
  "original_activity_id": 25865071,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "9656b305d27c643f77c5ff46a77f8bedcd4391cd1008b7acdf4d73fe8fd62b90",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865071",
  "original_value": "39.81",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865072ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865072",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5566275",
  "molecule_inchikey": "BRXGRHRYSGOUIW-UHFFFAOYSA-N",
  "original_activity_id": 25865072,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "27f809e7a3d50d814b295567a0647a7e61d8ca6fe597534bae89d89f58e068e5",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865072",
  "original_value": "25.12",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865073ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511281",
  "candidate_id": "CAND:CHEMBL:25865073",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865073,
  "original_assay_description": "Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells incubated for 45 mins by biochemical assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "1e9a2a2019340c942bbd0546715bdf864d50132dce8114d4d711c9995c1bcfeb",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865073",
  "original_value": "6.31",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 34,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865074ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865074",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865074,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "ac532f849d4cb45985f7bbe82d244cb8aef4bd5f176abfd365cfe4bc85f806bc",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865074",
  "original_value": "125.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865075ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865075",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5563959",
  "molecule_inchikey": "ABIXPIGGPYBTDD-UHFFFAOYSA-N",
  "original_activity_id": 25865075,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "3a2a260f1815ed7d180e820dae60c308973587dbf27372c5194a801debbce344",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865075",
  "original_value": "6309.57",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865076ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865076",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562861",
  "molecule_inchikey": "NMBPINFRTFCTEF-UHFFFAOYSA-N",
  "original_activity_id": 25865076,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "feb0eeb1b5082ef9dda6b7d7af66786efac66ecc53ff3f069bf838bca61dca71",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865076",
  "original_value": "251.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865077ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865077",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562153",
  "molecule_inchikey": "ULLWFQAIKLJZRX-UHFFFAOYSA-N",
  "original_activity_id": 25865077,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "436f78af889b5bf0219052af7987a397ae94c95eb9332d9d356e0a16d05a1a40",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865077",
  "original_value": "39.81",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865078ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865078",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557539",
  "molecule_inchikey": "MZLIUXKMCHXQNU-UHFFFAOYSA-N",
  "original_activity_id": 25865078,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "2b182ba5d738f9cc01321cbf5e49fbc5efd2a6c99284b7ef3144d7871e9e6791",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865078",
  "original_value": "125.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865079ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865079",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067693",
  "molecule_inchikey": "VEWYIWGYIVHOBN-UHFFFAOYSA-N",
  "original_activity_id": 25865079,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "b15aec088975c1532fe9cd13202262743d6b5c730c4ba2ccee811f33008dfa2f",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865079",
  "original_value": "125.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865080ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865080",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5555145",
  "molecule_inchikey": "BCEHCNGIJHAHTP-UHFFFAOYSA-N",
  "original_activity_id": 25865080,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "406701162abf5872432531b0d56d51ea07b14498cd37f5d2c4f87603b4b8917c",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865080",
  "original_value": "199.53",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865081ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865081",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517868",
  "molecule_inchikey": "DXBREQYPXPKCLM-UHFFFAOYSA-N",
  "original_activity_id": 25865081,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "a1390cb7cdfb874e348464ba167bb8d2203f6bfe1abf531b48fee8519594e275",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865081",
  "original_value": "39.81",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865082ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865082",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562340",
  "molecule_inchikey": "ZBWHBKUMYLPCMF-UHFFFAOYSA-N",
  "original_activity_id": 25865082,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "80e7737044422af97ddaf2e20c94de408d3a30931c5c706596a90bd84fa035aa",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865082",
  "original_value": "12.59",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865083ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865083",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5562663",
  "molecule_inchikey": "IRSPYYYZACJWSE-UHFFFAOYSA-N",
  "original_activity_id": 25865083,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "ae55b5a33a4d6db67af1ac2dac9462034168dba8b489c75b103bef3d26d533b8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865083",
  "original_value": "251.19",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865084ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865084",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557662",
  "molecule_inchikey": "CAXXUAPKMOVWIN-UHFFFAOYSA-N",
  "original_activity_id": 25865084,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "23f4b0aa25eebc4193172f1088620bc1afd77136e279c63cdcd027f1ab57d338",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865084",
  "original_value": "158.49",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865085ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865085",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5565515",
  "molecule_inchikey": "ZEZCOKVXQVYETH-UHFFFAOYSA-N",
  "original_activity_id": 25865085,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "ca4a8d5fa37cf06d4e947821c154be542307a7020b4bedef36a731aa7e513668",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865085",
  "original_value": "5011.87",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865086ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865086",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5561556",
  "molecule_inchikey": "CUALDSZSVUZWJN-UHFFFAOYSA-N",
  "original_activity_id": 25865086,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "c1e231d7ee86b4138e0d21367f55624169bd11c37871b91336fd472f4467dc5d",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865086",
  "original_value": "2511.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865087ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511282",
  "candidate_id": "CAND:CHEMBL:25865087",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865087,
  "original_assay_description": "Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "8b16f39731c0e3c3069a2818e6229386a94555931c1c0b2e6e673d53e197c842",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865087",
  "original_value": "2.512",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 14,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865088ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865088",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4778517",
  "molecule_inchikey": "WOAOENGFAAUUGT-UHFFFAOYSA-N",
  "original_activity_id": 25865088,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "d6c6ee07b373148a512c7d5f839f15472afe7c3fbd21c0630557f018703561d5",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865088",
  "original_value": "125.89",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865089ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865089",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5563959",
  "molecule_inchikey": "ABIXPIGGPYBTDD-UHFFFAOYSA-N",
  "original_activity_id": 25865089,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "pKd",
  "original_priority": 2,
  "original_record_sha256": "c2a85e15f5d2afd33d308fc8c96e2a8e33c7ddcf134815dd1b7b44a2d968b01e",
  "original_relation": null,
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865089",
  "original_value": null,
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865090ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865090",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560105",
  "molecule_inchikey": "MRMUTHUMMVEAMF-UHFFFAOYSA-N",
  "original_activity_id": 25865090,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "pKd",
  "original_priority": 2,
  "original_record_sha256": "2c8805c4e5d2c088c4732151482b03a91c7116ba5fdc55af8514c6516a9cf390",
  "original_relation": null,
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865090",
  "original_value": null,
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865091ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865091",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517868",
  "molecule_inchikey": "DXBREQYPXPKCLM-UHFFFAOYSA-N",
  "original_activity_id": 25865091,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "2f24c825b0e7eef987cd5363abdf076a65faa7ecc32ef2ca9a3a9f0ada9f43cf",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865091",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865092ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865092",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559177",
  "molecule_inchikey": "APUAYMXUHLOPLQ-UHFFFAOYSA-N",
  "original_activity_id": 25865092,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "a1eb9258c487005c7f2edabd843204c58e93b506d08f5bc3869d9e9a3e48139b",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865092",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865093ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865093",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5561556",
  "molecule_inchikey": "CUALDSZSVUZWJN-UHFFFAOYSA-N",
  "original_activity_id": 25865093,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "pKd",
  "original_priority": 2,
  "original_record_sha256": "95950d2adcd2ba03faf420867a6c19f0f52b3f67f204a61e29e7496f794b0c93",
  "original_relation": null,
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865093",
  "original_value": null,
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865094ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865094",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5527939",
  "molecule_inchikey": "IHCNPLSAPCQDEB-LJQANCHMSA-N",
  "original_activity_id": 25865094,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "e460fe943c5e60fd2523cc9d595435166c754a014174905c053d136262ea8441",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865094",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865095ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865095",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542933",
  "molecule_inchikey": "PZQHTJPFTVSYKN-GOSISDBHSA-N",
  "original_activity_id": 25865095,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "6be8e39d876545755a77199799eb570604c73803453baccb0129a7d15ea001d5",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865095",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865096ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865096",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556168",
  "molecule_inchikey": "PTDHIMCHWIFQJG-UHFFFAOYSA-N",
  "original_activity_id": 25865096,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "981df6b5b57d1b78b63879fb87a55c407382af05e3e17496748afef98d7c5dbd",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865096",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865097ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865097",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542423",
  "molecule_inchikey": "ATEQBDBQCUHGAY-UHFFFAOYSA-N",
  "original_activity_id": 25865097,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "fc84805ab8ea74e67a02a457913dc4fbdff285cffd59de2d36f5a018e83022fc",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865097",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865098ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865098",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5566275",
  "molecule_inchikey": "BRXGRHRYSGOUIW-UHFFFAOYSA-N",
  "original_activity_id": 25865098,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "8f710540a93350f5afb72a5ff4f99c7781416c35701699d617211bf34ab41de5",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865098",
  "original_value": "31622.78",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865099ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511283",
  "candidate_id": "CAND:CHEMBL:25865099",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865099,
  "original_assay_description": "Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "fcad947a0c95dc495c2b62a13708a4d54f103953b86e17e1e40da95da74c6e8c",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865099",
  "original_value": "25118.86",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 12,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865100ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865100",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4758943",
  "molecule_inchikey": "WYAGGMZTARRIDX-UHFFFAOYSA-N",
  "original_activity_id": 25865100,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "a05055c91a3de5d80e349d59e778b034df6f7454702585ccb24ae1cd062bd780",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865100",
  "original_value": "121000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865101ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865101",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865101,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "78a2793281381e9e71bcdb33c35ce6af7ab9a0dec5f9b510672f6279e437bf7e",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865101",
  "original_value": "1000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865102ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865102",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5563959",
  "molecule_inchikey": "ABIXPIGGPYBTDD-UHFFFAOYSA-N",
  "original_activity_id": 25865102,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "735bc6ef06f0c39f9a0c6dfd8d203b7eb404fa84f26877ab9389cd8ba5d1468d",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865102",
  "original_value": "979000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865103ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865103",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562861",
  "molecule_inchikey": "NMBPINFRTFCTEF-UHFFFAOYSA-N",
  "original_activity_id": 25865103,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "3be48fe6fea51864fd8441916a7d7f831d186c074b338dd63c2f10108824a745",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865103",
  "original_value": "205000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865104ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865104",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562153",
  "molecule_inchikey": "ULLWFQAIKLJZRX-UHFFFAOYSA-N",
  "original_activity_id": 25865104,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "0f591237e89fa578e88c691b4a9642bea568212bd34e595fd2a56fcc837368c4",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865104",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865105ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865105",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556655",
  "molecule_inchikey": "KEGFMQLKKFOVDX-UHFFFAOYSA-N",
  "original_activity_id": 25865105,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "1094cf5ba726eb23bf1e05a0f7126a04cfc43704e7dada17f3f2bcdfff6c403e",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865105",
  "original_value": "12000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865106ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865106",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560105",
  "molecule_inchikey": "MRMUTHUMMVEAMF-UHFFFAOYSA-N",
  "original_activity_id": 25865106,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "61b1a282122cccb0950f268de7e92164588b6244c65363450454008439f4edb7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865106",
  "original_value": "28000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865107ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865107",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557539",
  "molecule_inchikey": "MZLIUXKMCHXQNU-UHFFFAOYSA-N",
  "original_activity_id": 25865107,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "91f4e74fa6e31746c65b8f58631dafbfca66fd9ebba2d6f9c1ec922916fb6889",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865107",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865108ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865108",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067693",
  "molecule_inchikey": "VEWYIWGYIVHOBN-UHFFFAOYSA-N",
  "original_activity_id": 25865108,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "d4d1c65735a6ce39ec24f5d865d722288ff901cf99124b9e7c4e6bea2ca7fa6a",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865108",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865109ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865109",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5518061",
  "molecule_inchikey": "NQERJHKXGVIGAD-UHFFFAOYSA-N",
  "original_activity_id": 25865109,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "f1f7b753b01117b06561b0664fb57aab8d65e857d70ba4484b30ab86a2c9d557",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865109",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865110ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865110",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067694",
  "molecule_inchikey": "GFIQDMKDUFQAHX-UHFFFAOYSA-N",
  "original_activity_id": 25865110,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "22b55be75a139ad0f84506360576ac33126b49aa9ca435cbb8e011ad76b8ea1e",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865110",
  "original_value": "915000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865111ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865111",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5555145",
  "molecule_inchikey": "BCEHCNGIJHAHTP-UHFFFAOYSA-N",
  "original_activity_id": 25865111,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "69582661e9c3379b1b73b868b9c4cd3e955d788c8574d49384fb9844a1a7a2fd",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865111",
  "original_value": "71000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865112ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865112",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542909",
  "molecule_inchikey": "CDZHONALNGXILP-UHFFFAOYSA-N",
  "original_activity_id": 25865112,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "9fdfa56603d2ec2fa9d2821f48b9c3110f6163f87e0b3c62b3362064e8adf45f",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865112",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865113ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865113",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517868",
  "molecule_inchikey": "DXBREQYPXPKCLM-UHFFFAOYSA-N",
  "original_activity_id": 25865113,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "8a640db9e67d906c1e960ae2d5492c54f4221ccdcd84c347bd0da860582f7fa0",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865113",
  "original_value": "900000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865114ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865114",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562340",
  "molecule_inchikey": "ZBWHBKUMYLPCMF-UHFFFAOYSA-N",
  "original_activity_id": 25865114,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "e01fa36fc717c6f169e15b073debebb46f415b140acddd44ce36e1ab40da8f55",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865114",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865115ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865115",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559177",
  "molecule_inchikey": "APUAYMXUHLOPLQ-UHFFFAOYSA-N",
  "original_activity_id": 25865115,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "b68a71c1f588e53e60e96243fed9ae468c31022889e04088a6595d18d771298c",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865115",
  "original_value": "4000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865116ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865116",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5562663",
  "molecule_inchikey": "IRSPYYYZACJWSE-UHFFFAOYSA-N",
  "original_activity_id": 25865116,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "da7daf2749385c40251934b0f38494ba4ed8f2a427ec93b2b1a710aa9376614b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865116",
  "original_value": "2000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865117ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865117",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557662",
  "molecule_inchikey": "CAXXUAPKMOVWIN-UHFFFAOYSA-N",
  "original_activity_id": 25865117,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "4a13645995b96ba0e1ec4f8e78d2ea21b9e4b7db5add4cbd8065eb7e5b1148b5",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865117",
  "original_value": "1100.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865118ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865118",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5565515",
  "molecule_inchikey": "ZEZCOKVXQVYETH-UHFFFAOYSA-N",
  "original_activity_id": 25865118,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "6b6c1d4749e7b390492a47b0f06bba7851d4df40d4c39f63fcdee8cd39fdc806",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865118",
  "original_value": "4000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865119ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865119",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5561556",
  "molecule_inchikey": "CUALDSZSVUZWJN-UHFFFAOYSA-N",
  "original_activity_id": 25865119,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "cfd7be8520d60c0cdc1978cd2c48a439e7003066fdd96aaca7c760a59b40cdc3",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865119",
  "original_value": "55000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865120ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865120",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560960",
  "molecule_inchikey": "OUOZZTLCSMEGMB-GOSISDBHSA-N",
  "original_activity_id": 25865120,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "660da5c3510e7b0ed0d09db55d6a9e9ff563fb934666d53fe1144e61d2201ebf",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865120",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865121ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865121",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532580",
  "molecule_inchikey": "HUWXNQUPNJTKDZ-UHFFFAOYSA-N",
  "original_activity_id": 25865121,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "e32d12649f2215ae1a59e12c7a2b0dea003df30057d40565903b7a75ee85c050",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865121",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865122ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865122",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562333",
  "molecule_inchikey": "ICIKTJUZMIFHRD-QGZVFWFLSA-N",
  "original_activity_id": 25865122,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "bb403d095e4ef1d9a2d25f7fcc55e6d576768dcefefc7e4632d375ed7a213f09",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865122",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865123ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865123",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532365",
  "molecule_inchikey": "NGQMSCPPMHZUPJ-UHFFFAOYSA-N",
  "original_activity_id": 25865123,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "98659dc85aef8260a5df7deff1d98dfdd09f67895ea813817fdbb8462e328ddd",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865123",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865124ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865124",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5527939",
  "molecule_inchikey": "IHCNPLSAPCQDEB-LJQANCHMSA-N",
  "original_activity_id": 25865124,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "1de51384d92fd732ba3c77613579b3ea65776c962902713c47044ea7a123ca0a",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865124",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865125ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865125",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542933",
  "molecule_inchikey": "PZQHTJPFTVSYKN-GOSISDBHSA-N",
  "original_activity_id": 25865125,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "f982f67fdb394b8ac3563f82a8c1c1d9b543a4f0a00d619136365d314db64366",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865125",
  "original_value": "975000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865126ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865126",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532583",
  "molecule_inchikey": "KTVJINSMSOLPAV-UHFFFAOYSA-N",
  "original_activity_id": 25865126,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "4b5b57e2274559e1713ceb09b2f75135f53f78fc8cc9f0b2436cb0cc12188aae",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865126",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865127ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865127",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517660",
  "molecule_inchikey": "YZOCGUCOBQCCGW-SFHVURJKSA-N",
  "original_activity_id": 25865127,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "a3ef3e7dbadeab3be13b38a720e09854ec412792e36e82334bf180db48df9134",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865127",
  "original_value": "1000000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865128ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865128",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556330",
  "molecule_inchikey": "YZOCGUCOBQCCGW-GOSISDBHSA-N",
  "original_activity_id": 25865128,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "c4963630eaeaa9bb15b356ddbde893c28aa76f29eeaaa10d851096351e3362d7",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865128",
  "original_value": "982000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865129ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865129",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556168",
  "molecule_inchikey": "PTDHIMCHWIFQJG-UHFFFAOYSA-N",
  "original_activity_id": 25865129,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "7d9f3e4a1bbf2465b220eff419ff4ab20136e3b9d0a7819889062661f32bfb48",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865129",
  "original_value": "757000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865130ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865130",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542423",
  "molecule_inchikey": "ATEQBDBQCUHGAY-UHFFFAOYSA-N",
  "original_activity_id": 25865130,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "0b9a6e9e0d7818c5f2a27243cfb4212c8a99f7fb71a5e247e2b6400707ada9e2",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865130",
  "original_value": "8000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865131ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865131",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5566275",
  "molecule_inchikey": "BRXGRHRYSGOUIW-UHFFFAOYSA-N",
  "original_activity_id": 25865131,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "9abf4ee2b30ac0a9bf599c4dcd0ce2388bddaa838b9193b69e357b445c869c33",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865131",
  "original_value": "501000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865132ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511284",
  "candidate_id": "CAND:CHEMBL:25865132",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865132,
  "original_assay_description": "Thermodynamic solubility of the compound at pH 7.4 incubated for 24 hrs",
  "original_endpoint": "Solubility",
  "original_priority": 2,
  "original_record_sha256": "7e575400bdc6a40d9a56172395a2e78c37ee1922bb964d5caeadc3df2c9bc998",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865132",
  "original_value": "4000.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 33,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865133ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865133",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4758943",
  "molecule_inchikey": "WYAGGMZTARRIDX-UHFFFAOYSA-N",
  "original_activity_id": 25865133,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "72bbfb30633ea6f37329240bc01e397f52a5a5054c571de32203a07e0975e075",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865133",
  "original_value": "2.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865134ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865134",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865134,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "1d7ab5ed8df1f3fd74fb8bee308176d99cdbbfdee20f7f025f4b8e6d7282aa66",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865134",
  "original_value": "2.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865135ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865135",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5563959",
  "molecule_inchikey": "ABIXPIGGPYBTDD-UHFFFAOYSA-N",
  "original_activity_id": 25865135,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "9b2fa529be3f431d021c631309bc09e6bb0c5814a4ee11e51f0599850e2822ae",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865135",
  "original_value": "1.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865136ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865136",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562861",
  "molecule_inchikey": "NMBPINFRTFCTEF-UHFFFAOYSA-N",
  "original_activity_id": 25865136,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "02076246b65e0dd4c9d61f12e723eb4ffe2c2784e6b82c76e65dd5f00dcd10aa",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865136",
  "original_value": "1.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865137ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865137",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562153",
  "molecule_inchikey": "ULLWFQAIKLJZRX-UHFFFAOYSA-N",
  "original_activity_id": 25865137,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "2571baead7469282cb16a42325e99f975c1ae325abd94c93935fa4588435812b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865137",
  "original_value": "0.1",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865138ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865138",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556655",
  "molecule_inchikey": "KEGFMQLKKFOVDX-UHFFFAOYSA-N",
  "original_activity_id": 25865138,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "d1a883524d61362008457286c7f2f5a81c4dc953afbf6af9d844c73fb4b9f21c",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865138",
  "original_value": "2.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865139ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865139",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560105",
  "molecule_inchikey": "MRMUTHUMMVEAMF-UHFFFAOYSA-N",
  "original_activity_id": 25865139,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "4cf039bc9e13a4747b22e6876ab17c7531d56bc714e4d90ab96100ecd9658611",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865139",
  "original_value": "2.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865140ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865140",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557539",
  "molecule_inchikey": "MZLIUXKMCHXQNU-UHFFFAOYSA-N",
  "original_activity_id": 25865140,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "f66aa5b1282db882af476ec03d0eff2e4bca69090fd6e401f62677dd323bd2cb",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865140",
  "original_value": "2.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865141ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865141",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067693",
  "molecule_inchikey": "VEWYIWGYIVHOBN-UHFFFAOYSA-N",
  "original_activity_id": 25865141,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "cf193b54aa067ce3fde67ccceabb237a81ee1690f132d9942605f50ef37164eb",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865141",
  "original_value": "1.9",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865142ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865142",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5518061",
  "molecule_inchikey": "NQERJHKXGVIGAD-UHFFFAOYSA-N",
  "original_activity_id": 25865142,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "b339879c495f8a66b4935aae58e932811f49137b0e25bad6cd05a3fe2d26957b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865142",
  "original_value": "0.8",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865143ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865143",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL6067694",
  "molecule_inchikey": "GFIQDMKDUFQAHX-UHFFFAOYSA-N",
  "original_activity_id": 25865143,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "bba99402a532fe464d566973733c7ff70956ad9a47771ade336998872774cc7b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865143",
  "original_value": "1.9",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865144ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865144",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5555145",
  "molecule_inchikey": "BCEHCNGIJHAHTP-UHFFFAOYSA-N",
  "original_activity_id": 25865144,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "cc0e59580d38b25879faaee881234d0073b16b3ae74a98f285ee406a45f863a1",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865144",
  "original_value": "1.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865145ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865145",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542909",
  "molecule_inchikey": "CDZHONALNGXILP-UHFFFAOYSA-N",
  "original_activity_id": 25865145,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "06ddaea82a5c80900255d2f8d4a4aedd49ffacb83cc09d82dc4645aab10d0501",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865145",
  "original_value": "1.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865146ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865146",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562340",
  "molecule_inchikey": "ZBWHBKUMYLPCMF-UHFFFAOYSA-N",
  "original_activity_id": 25865146,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "4d8cba62b0aeb10ef118c0aee2ac70dff51062559cc8c5a7038347aa84f023e2",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865146",
  "original_value": "1.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865147ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865147",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559177",
  "molecule_inchikey": "APUAYMXUHLOPLQ-UHFFFAOYSA-N",
  "original_activity_id": 25865147,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "278ba42c677830c63e4e4b353551716109174df418f5b4a9d8f582dc7428eb40",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865147",
  "original_value": "3.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865148ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865148",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5562663",
  "molecule_inchikey": "IRSPYYYZACJWSE-UHFFFAOYSA-N",
  "original_activity_id": 25865148,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "1f02cccf744cadeeecc95168bb34dcf798605b20e27eeebfe87a8c79c0481ea5",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865148",
  "original_value": "3.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865149ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865149",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5557662",
  "molecule_inchikey": "CAXXUAPKMOVWIN-UHFFFAOYSA-N",
  "original_activity_id": 25865149,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "22067f1393ca5becfbf65e5976b1f7e3706979ee6c9468bde2156f6f49067d8f",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865149",
  "original_value": "2.3",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865150ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865150",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5565515",
  "molecule_inchikey": "ZEZCOKVXQVYETH-UHFFFAOYSA-N",
  "original_activity_id": 25865150,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "bfc3c683cee9ed53265a707f43985216a3be9887afc2c07fec16a21c06dcd9a2",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865150",
  "original_value": "4.2",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865151ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865151",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5561556",
  "molecule_inchikey": "CUALDSZSVUZWJN-UHFFFAOYSA-N",
  "original_activity_id": 25865151,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "e22b86a75c8f01ae8d722f37912ed6ee2587a244b57d22bf76bb2e07e2dad64e",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865151",
  "original_value": "1.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865152ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865152",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5560960",
  "molecule_inchikey": "OUOZZTLCSMEGMB-GOSISDBHSA-N",
  "original_activity_id": 25865152,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "ca0e72a4c05a2a237755663ed081abd7d8346d17c486af692fe99842c088b9c8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865152",
  "original_value": "0.1",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865153ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865153",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532580",
  "molecule_inchikey": "HUWXNQUPNJTKDZ-UHFFFAOYSA-N",
  "original_activity_id": 25865153,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "55a0f8af0c183c5ff9de4fe0a823b25bf855d9dd05bd5482d9a17dfddec17dcc",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865153",
  "original_value": "1.4",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865154ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865154",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5562333",
  "molecule_inchikey": "ICIKTJUZMIFHRD-QGZVFWFLSA-N",
  "original_activity_id": 25865154,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "af3da5e039b306b833f8be128ebe1819934c51a8eeb2ce59d33500da124ea12b",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865154",
  "original_value": "0.3",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865155ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865155",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532365",
  "molecule_inchikey": "NGQMSCPPMHZUPJ-UHFFFAOYSA-N",
  "original_activity_id": 25865155,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "ac79d18e97de3b660ed9fc43a18a734d60f835f0827c3dce04368a63adec2ffd",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865155",
  "original_value": "1.3",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865156ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865156",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5527939",
  "molecule_inchikey": "IHCNPLSAPCQDEB-LJQANCHMSA-N",
  "original_activity_id": 25865156,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "9a4d43b88eb45be9b4c9cb3c3cc22540aa93946600e511fb18fb1acb90141168",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865156",
  "original_value": "1.1",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865157ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865157",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542933",
  "molecule_inchikey": "PZQHTJPFTVSYKN-GOSISDBHSA-N",
  "original_activity_id": 25865157,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "55f78f34ec291036d004badc780c3452aca5be269a59deed8d414d85f372be5e",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865157",
  "original_value": "1.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865158ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865158",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5532583",
  "molecule_inchikey": "KTVJINSMSOLPAV-UHFFFAOYSA-N",
  "original_activity_id": 25865158,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "4d8036de8a14d0c8019603a53c536ba548061e845093b684ba1916a47fdfb798",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865158",
  "original_value": "0.8",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865159ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865159",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5517660",
  "molecule_inchikey": "YZOCGUCOBQCCGW-SFHVURJKSA-N",
  "original_activity_id": 25865159,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "ef93dfac0cf0e2ea86fd0949dc97fd2f3bf0a9a55d5d2afe0f773d7d21565ae5",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865159",
  "original_value": "1.3",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865160ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865160",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556330",
  "molecule_inchikey": "YZOCGUCOBQCCGW-GOSISDBHSA-N",
  "original_activity_id": 25865160,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "a647c88d9628cc176f1be055b3dcf34fc4dd08b5548911dcf4bf11a0b10fa40a",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865160",
  "original_value": "1.2",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865161ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865161",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5556168",
  "molecule_inchikey": "PTDHIMCHWIFQJG-UHFFFAOYSA-N",
  "original_activity_id": 25865161,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "f846de9c4dd60072c6ad1a113467f9b63e60d843ac5e37395c919e52084a5a14",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865161",
  "original_value": "2.1",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865162ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865162",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5542423",
  "molecule_inchikey": "ATEQBDBQCUHGAY-UHFFFAOYSA-N",
  "original_activity_id": 25865162,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "338de20366c6c5b6e53fd5e8cff3374788f9567f9db44a47ee13b91ae47a0131",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865162",
  "original_value": "2.9",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865163ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865163",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": false,
  "molecule_chembl_id": "CHEMBL5566275",
  "molecule_inchikey": "BRXGRHRYSGOUIW-UHFFFAOYSA-N",
  "original_activity_id": 25865163,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "2ec26b2eb08c84f0933f003fa269f3f061dab7c554093a5d5d90da6d7f03dfb8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865163",
  "original_value": "3.2",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865164ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511285",
  "candidate_id": "CAND:CHEMBL:25865164",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865164,
  "original_assay_description": "Lipophilicity, logD of the compound at pH 7.4 by shake flask assay",
  "original_endpoint": "LogD",
  "original_priority": 2,
  "original_record_sha256": "6d868c9201e802d8952418c66815b279d121d71c73d06b8e625c51736ef9d182",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": null,
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865164",
  "original_value": "2.6",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 32,
  "source_bao_format": "small-molecule physicochemical format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "No relevant target"
}
CAND:CHEMBL:25865165ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511286",
  "candidate_id": "CAND:CHEMBL:25865165",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865165,
  "original_assay_description": "Passive permeability in human Caco-2 cells",
  "original_endpoint": "permeability",
  "original_priority": 2,
  "original_record_sha256": "a4b26727a03d12f8b42a72a3d3000706e1bb7f25f64a2f55a9b6cea0e9958d79",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "10^-6 cm/s",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865165",
  "original_value": "16.3",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865166ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511287",
  "candidate_id": "CAND:CHEMBL:25865166",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865166,
  "original_assay_description": "Inhibition of C-terminal nanoluc-tagged NSD2 PWWP1 domain (208 to 396 residues) in human U2OS cells incubated for 2 hrs by NanoBRET target engagement assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "bb410a763afeaf79f2e5807db2e026c773060848e0358c60fc04350650b327d9",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865166",
  "original_value": "3.981",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865167ChEMBL
Source link		protein level evidence only
not_individually_verified

Cellular histone-mark response is not purified PWWP-domain affinity; primary original observation verification remains outstanding

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511288",
  "candidate_id": "CAND:CHEMBL:25865167",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865167,
  "original_assay_description": "Inhibition of NSD2 in human KMS-11 cells assessed as reduction in H3K36me2 levels incubated for 72 hrs by immunofluorescence assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "4324452696c47417189f9cce1bc4877ea2e16a7d6add11f3af6e8944046efadc",
  "original_relation": "\u003e",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865167",
  "original_value": "31622.78",
  "outcome": "protein_level_evidence_only",
  "outcome_reason": "Cellular histone-mark response is not purified PWWP-domain affinity; primary original observation verification remains outstanding",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "cell-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865168ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511289",
  "candidate_id": "CAND:CHEMBL:25865168",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865168,
  "original_assay_description": "Clearance in Wistar rat plasma at 0.5 mg/kg, iv measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "CL",
  "original_priority": 2,
  "original_record_sha256": "b339bb39562d2b1387fee1c866e9d54c9a3f47c00e98ba0d80465f337989fa30",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "mL.min-1.kg-1",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865168",
  "original_value": "50.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865169ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511290",
  "candidate_id": "CAND:CHEMBL:25865169",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865169,
  "original_assay_description": "Half life in Wistar rat at 0.5 mg/kg, iv measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "T1/2",
  "original_priority": 2,
  "original_record_sha256": "f12f04e209b4ecd7cd93cf1affc7330beba7847ab020cb31e8a2b42b254c4285",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "hr",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865169",
  "original_value": "0.61",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865170ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511291",
  "candidate_id": "CAND:CHEMBL:25865170",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865170,
  "original_assay_description": "Volume of distribution at steady state in Wistar rat at 0.5 mg/kg, iv measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "Vdss",
  "original_priority": 2,
  "original_record_sha256": "16b9a1bf259a3247f67ce6371ed2a0b1762a5a4357bcd3c0944df5ca607737d8",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "L.kg-1",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865170",
  "original_value": "1.9",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865171ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511292",
  "candidate_id": "CAND:CHEMBL:25865171",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865171,
  "original_assay_description": "Cmax in Wistar rat at 1.0 mg/kg, po measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "Cmax",
  "original_priority": 2,
  "original_record_sha256": "e3312d401dfc86233faf60420bed2d14733d5dacb52c36f7ffed30c8b50dddbd",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865171",
  "original_value": "6.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865172ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511293",
  "candidate_id": "CAND:CHEMBL:25865172",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865172,
  "original_assay_description": "Tmax in Wistar rat at 1.0 mg/kg, po measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "Tmax",
  "original_priority": 2,
  "original_record_sha256": "a5b7f387731eb4509f01c33b2aa88bc2642230bed2ddf15167ec52af97a5ba23",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "hr",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865172",
  "original_value": "0.5",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865173ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511294",
  "candidate_id": "CAND:CHEMBL:25865173",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865173,
  "original_assay_description": "AUC infinity in Wistar rat at 1.0 mg/kg, po measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "AUC",
  "original_priority": 2,
  "original_record_sha256": "fb7b5430cc0846603a5228030a03117e511ce94909d944ed6ac7974ed46da003",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "ng.hr.mL-1",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865173",
  "original_value": "6.263",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865174ChEMBL
Source link		out of scope
not_individually_verified

Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511295",
  "candidate_id": "CAND:CHEMBL:25865174",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5559507",
  "molecule_inchikey": "GCVYFXYBQCKHCH-UHFFFAOYSA-N",
  "original_activity_id": 25865174,
  "original_assay_description": "Oral bioavailability in Wistar rat at 1.0 mg/kg measured upto 1440 mins by LC-MS/MS analysis",
  "original_endpoint": "F",
  "original_priority": 2,
  "original_record_sha256": "d13b88105e827f017677a64798b081c10daf0e23a83e9afe317ad8dceb8af3d0",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "%",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865174",
  "original_value": "2.0",
  "outcome": "out_of_scope",
  "outcome_reason": "Source reports physicochemical or ADMET data, not a PWWP binding/functional assay; retained in candidate evidence",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "organism-based format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "ADMET"
}
CAND:CHEMBL:25865175ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511296",
  "candidate_id": "CAND:CHEMBL:25865175",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL4778517",
  "molecule_inchikey": "WOAOENGFAAUUGT-UHFFFAOYSA-N",
  "original_activity_id": 25865175,
  "original_assay_description": "Inhibition of NSD3 PWWP1 domain (unknown origin) by TR-FRET assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "2e9d03829d47dc305d0c03468280b6377ac8e860148b77f8fde5e0c1a1fa9926",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865175",
  "original_value": "200.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "single protein format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": true,
  "source_target": "Histone-lysine N-methyltransferase NSD3"
}
CAND:CHEMBL:25865176ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511297",
  "candidate_id": "CAND:CHEMBL:25865176",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865176,
  "original_assay_description": "Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant by SPR analysis",
  "original_endpoint": "Kd",
  "original_priority": 2,
  "original_record_sha256": "507e89d6099fc7df350d517eee191b303cbff797d31704e36d1e5ed5458acbbc",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865176",
  "original_value": "91.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "single protein format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": true,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865177ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511298",
  "candidate_id": "CAND:CHEMBL:25865177",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865177,
  "original_assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by alphascreen assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "826ee8472b225ca64dace3f183ca187e04c27312509ca89dc1b9c1f51d60ed5c",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865177",
  "original_value": "104.0",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "single protein format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": true,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:CHEMBL:25865178ChEMBL
Source link		relevant but unresolved
not_individually_verified

Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission

Full source/provenance record
{
  "assay_chembl_id": "CHEMBL5511299",
  "candidate_id": "CAND:CHEMBL:25865178",
  "document_chembl_id": "CHEMBL5506052",
  "identity_already_in_phase5": true,
  "molecule_chembl_id": "CHEMBL5200945",
  "molecule_inchikey": "KOZGEDUWAQFVAV-UHFFFAOYSA-N",
  "original_activity_id": 25865178,
  "original_assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by NanoBRET target engagement assay",
  "original_endpoint": "IC50",
  "original_priority": 2,
  "original_record_sha256": "dc272df096c66646916bd4d5469861ee3703d72c8cecdad9ef89cc65408cbca4",
  "original_relation": "=",
  "original_status": "candidate_not_promoted",
  "original_units": "nM",
  "original_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865178",
  "original_value": "1.23",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Original publication compound-number, method, construct and independent-measurement mapping not fully checked; ChEMBL activity does not establish admission",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": "P5:S:CARLINO2024",
  "same_assay_source_record_count": 1,
  "source_bao_format": "single protein format",
  "source_kind": "ChEMBL",
  "source_potential_duplicate": false,
  "source_target": "Histone-lysine N-methyltransferase NSD2"
}
CAND:LIT:HRP_family_fragment_seriesprimary literature
Source link		relevant but unresolved
not_individually_verified

Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:HRP_family_fragment_series",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "76fd4c2b99eb02b9ad0a7a03452672c49c2e70354ad6d4b39be618024faf4bae",
  "original_status": "candidate_not_promoted",
  "original_url": "https://doi.org/10.1016/j.ejmech.2024.116960",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:LIT:HS13primary literature
Source link		duplicate existing evidence
abstract_and_preview_inspected_incomplete

Qualitative HS13 association already in PWWP:ASSAY:0035; source-reported new quantitative values remain separate deferred leads and must not double-count old assay

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:HS13",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "f512470e7dad84012658a6a62012c15de37b3a2fb44875c017db449bc2ff8585",
  "original_status": "candidate_not_promoted",
  "original_url": "https://doi.org/10.1016/j.bmc.2026.118751",
  "outcome": "duplicate_existing_evidence",
  "outcome_reason": "Qualitative HS13 association already in PWWP:ASSAY:0035; source-reported new quantitative values remain separate deferred leads and must not double-count old assay",
  "primary_source_review": "abstract_and_preview_inspected_incomplete",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:LIT:LY-06primary literature
Source link		relevant but unresolved
publisher_abstract_reviewed_only

Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:LY-06",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "82b84f54d2bc71309f89d29b0ff4936775e175684402e8af93e5c56ede1adb7b",
  "original_status": "candidate_not_promoted",
  "original_url": "https://pubmed.ncbi.nlm.nih.gov/41820229/",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate",
  "primary_source_review": "publisher_abstract_reviewed_only",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:LIT:NSD2-LDDprimary literature
Source link		relevant but unresolved
not_individually_verified

Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:NSD2-LDD",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "a7b9f8b99b3ad81a3ca4c45e2e786645ae1927fb56c20959da79535fce8ea17b",
  "original_status": "candidate_not_promoted",
  "original_url": "https://doi.org/10.1182/blood.2025031998",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:LIT:UNC10415667_/_UNC10088primary literature
Source link		accepted with bounded interpretation
source_figures_and_methods_verified_for_linked_observations

Four independent reported outcomes from primary 2026 Figure 2h/3e/4h verified with endpoints and target scope separated; preparation identity remains unresolved

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:UNC10415667_/_UNC10088",
  "document_chembl_id": null,
  "linked_new_observation_ids": [
    "P6B:ASSAY:0001",
    "P6B:ASSAY:0002",
    "P6B:ASSAY:0003",
    "P6B:ASSAY:0004"
  ],
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "8250b1ec471e070cb5a3ace45fe78df0f55b48be67fbbdfd4d365da72185040a",
  "original_status": "candidate_not_promoted",
  "original_url": "https://www.nature.com/articles/s41467-026-72235-9",
  "outcome": "accepted_with_bounded_interpretation",
  "outcome_reason": "Four independent reported outcomes from primary 2026 Figure 2h/3e/4h verified with endpoints and target scope separated; preparation identity remains unresolved",
  "primary_source_review": "source_figures_and_methods_verified_for_linked_observations",
  "promoted_as_accepted_observation": true,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:LIT:XSY12primary literature
Source link		relevant but unresolved
publisher_abstract_reviewed_only

Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:LIT:XSY12",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 1,
  "original_record_sha256": "bda36e5ccd4b15bc0ad2b9a7b4ad6f60fb31138342d08fa15fd65e8b981dab7e",
  "original_status": "candidate_not_promoted",
  "original_url": "https://pubmed.ncbi.nlm.nih.gov/42503659/",
  "outcome": "relevant_but_unresolved",
  "outcome_reason": "Source lead metadata or accessible abstract reviewed where indicated; no complete record-level identity/construct reconciliation for this original candidate",
  "primary_source_review": "publisher_abstract_reviewed_only",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "primary literature"
}
CAND:NAME:MR927unknown
out of scope
not_individually_verified

MR927 exact label remains unverified; never replace with MR837

Full source/provenance record
{
  "assay_chembl_id": null,
  "candidate_id": "CAND:NAME:MR927",
  "document_chembl_id": null,
  "molecule_chembl_id": null,
  "original_priority": 3,
  "original_record_sha256": "dc1abf8ead909e3e1a6bb2346e6d3d610bf96bfa171c9237f086e605b53b5fc0",
  "original_status": "excluded_unverified_name",
  "original_url": null,
  "outcome": "out_of_scope",
  "outcome_reason": "MR927 exact label remains unverified; never replace with MR837",
  "primary_source_review": "not_individually_verified",
  "promoted_as_accepted_observation": false,
  "publication": null,
  "source_kind": "unknown"
}