PWWPAtlas
STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments
Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Reported experimental preparation

UNC8884

Studied · no deposited PWWP research ligandExperimental controlNegative / censored observationsPreparation identity unresolved

Named experimental preparation supported by primary publication; no exact molecular depiction assigned until identity is independently resolved.

NSD2 PWWP1
1 assay / association records1 preparations0 research-ligand PDB entries

No deposited PWWP research-ligand geometry is classified for this preparation in the selected release. Deposition of a buffer/ion is not binding evidence.

Clinical / development status: Not independently curated. A chemical probe classification does not imply medicinal approval.

Identity is separate from preparation

Chemical identity

Measured target and original context

Bioactivity & experimental observations

Download assay CSV

Each row is one source-specific observation. Repeated measurements of this compound are not independent compounds. Direct binding, functional displacement and cellular outcomes retain their distinct endpoints.

PreparationTested target & constructMethod / endpointOriginal observationConditions & uncertaintySource & verification
UNC8884PREP:UNC8884Negative / censored NSD2 PWWP1
Construct not curatedHomo sapiens		 qualitativeSPR qualitative no bindingqualitative control NB (no binding); no numeric Kd assigned.
Experimental context
Replicates
Not curated
Uncertainty definition
Not curated; do not assume SD or SEM
Temperature
°C
Buffer
Not curated
Conditions
Not curated
Qualification
Table reports NB for binding and ND for degradation endpoints; ND means not determined and is not converted to zero or inactivity.
 PMID:38965384 · 2024Official publisher Table 1 image visually inspected; table footnote and Supplementary Figures 1-2 inspected; identities compared to primary structures
Original observation record
{
  "assay_construct_end": null,
  "assay_construct_start": null,
  "assay_context": "purified_domain",
  "assay_organism": "Homo sapiens",
  "assay_record_id": "PWWP5:ASSAY:0024",
  "assay_type": "SPR qualitative no binding",
  "assay_value_transferred_to_modeled_stereoisomers": false,
  "ccd_id": null,
  "chemical_id": null,
  "compound_name": "UNC8884",
  "conditions": {},
  "domain": "PWWP1",
  "domain_id": "UP:O96028:PWWP1",
  "endpoint": "qualitative",
  "evidence_class": "qualitative_control",
  "evidence_location": "Table 1; Supplementary Figure 1",
  "evidence_url": "https://www.nature.com/articles/s41589-024-01660-y",
  "gene": "NSD2",
  "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.",
  "is_negative": true,
  "negative_control_scope": "Matched NSD2 ligand-binding negative control",
  "negative_evidence_scope": "Explicit SPR NB result; no numeric threshold or affinity inferred.",
  "numeric_transcription_status": "qualitative_or_not_reported",
  "numeric_value_inferred_from_structure": false,
  "pdb_id": null,
  "preparation_id": "PREP:UNC8884",
  "protein_id": "UP:O96028",
  "publication_year": 2024,
  "qualitative_result": "NB (no binding); no numeric Kd assigned.",
  "reference_id": "PMID:38965384",
  "remaining_uncertainty": "Table reports NB for binding and ND for degradation endpoints; ND means not determined and is not converted to zero or inactivity.",
  "replicates": null,
  "retrieval_date": "2026-10-26",
  "role": "negative_control",
  "source_id": "P5:S:NIE2024",
  "source_reported_uncertainty": null,
  "source_reported_units": null,
  "source_reported_value": null,
  "source_verification_scope": "Official publisher Table 1 image visually inspected; table footnote and Supplementary Figures 1-2 inspected; identities compared to primary structures",
  "uncertainty": null,
  "uncertainty_type": null,
  "uncertainty_uM": null,
  "units": null,
  "value": null,
  "value_operator": null,
  "value_uM": null,
  "verification_level": "primary_source_verified",
  "version": "phase5.chemical_curation.1.1.0"
}

Exact deposited instances

Experimental structures

No verified exact-identity bound structure

The biochemical or cellular evidence remains fully available. No artificial pose has been assigned.

Preparations, identities and controls remain separate

Experimental context

UNC8884

PREP:UNC8884

Named experimental preparation supported by primary publication; no exact molecular depiction assigned until identity is independently resolved.

negative control
Complete preparation record
{
  "chemical_id": null,
  "clinical_status": "not independently assessed",
  "curation_version": "phase5-1.0.0",
  "entity_type": "small_molecule_preparation",
  "identity_note": "Named experimental preparation supported by primary publication; no exact molecular depiction assigned until identity is independently resolved.",
  "identity_status": "paper_label_exact_identity_unresolved",
  "molecular_entity_type": "small_molecule_preparation",
  "name": "UNC8884",
  "phase5_identity_overlay": false,
  "preparation_id": "PREP:UNC8884",
  "retrieval_date": "2026-10-26",
  "role": "negative_control",
  "source_id": "P5:S:NIE2024",
  "source_url": "https://www.nature.com/articles/s41589-024-01660-y",
  "version": "phase5.chemical_curation.1.1.0"
}

Source-supported relationships

RelationshipRelated identity / preparationScopeSource
negative control forUNC8732matched PWWP1-binding negative controlSource

Provenance and reproducibility

Sources & downloads

https://www.nature.com/articles/s41589-024-01660-y
Download complete evidence JSONCuration methods & source receipts

Snapshot 2026-10-26 · phase5-1.0.0 · original measurements, operators, constructs and uncertainty are retained in the exports.