{
  "version": "phase6a-1.0.0",
  "source_sha256": "9b687df9abc3e6434d5f244d2ab94c6ee5566c685e1a74bd59ec4c466b947b0b",
  "status": "passed",
  "counts": {
    "identities": 148,
    "profiles": 163,
    "preparations": 30,
    "observations": 80,
    "studied_compound_profiles": 26,
    "direct_positive_binder_profiles": 20,
    "reported_probe_profiles": 2,
    "reported_control_profiles": 5,
    "cellular_activity_profiles": 2,
    "degradation_profiles": 7,
    "structural_research_ligand_profiles": 109,
    "other_pdb_component_profiles": 21,
    "unresolved_review_profiles": 28,
    "studied_bioactivity_only_profiles": 19,
    "site_records": 1996,
    "structural_research_contact_sites": 283,
    "all_exact_contact_sites": 1278,
    "other_component_sites": 1081,
    "candidate_only": 150,
    "review_flags": 38,
    "hard_failures": 0
  },
  "findings": [
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0001",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0002",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0003",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0004",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0005",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0006",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0007",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0008",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0009",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "observation_verification_scope",
      "severity": "review",
      "subject_id": "PWWP11:ASSAY:0010",
      "detail": "Original primary-source section verification not recorded; endpoint retained without upgrading confidence"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:LOFCJGPTBIGJGR-SECBINFHSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:HFHPBMVMXFZJNO-MRVPVSSYSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:KKBVPDRSYCAPEU-UHFFFAOYSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:QLSDWIHANVSIEK-SECBINFHSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:DBSDZVMWEMKFCH-QMMMGPOBSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:AIMZAKOWTDKKHP-HNECRKQMSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:WOAOENGFAAUUGT-UHFFFAOYSA-N",
      "detail": "source conflict retained"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:XVOYSCVBGLVSOL-REOHCLBHSA-N",
      "detail": "1 source sites have context-unresolved roles"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:H4K20me3_11mer",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:HS13",
      "detail": "chemical identity / preparation unresolved; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:MS9715N",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:MXNRLFUSFKVQSK-QMMMGPOBSA-O",
      "detail": "23 source sites have context-unresolved roles"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:NbH10",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:UNC7753",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:UNC8269",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:UNC8325",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:UNC8587",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:UNC8884",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "CCD_UNRESOLVED:UNX",
      "detail": "chemical identity / preparation unresolved; 224 source sites have context-unresolved roles"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "CCD_UNRESOLVED:UNL",
      "detail": "chemical identity / preparation unresolved; 2 source sites have context-unresolved roles"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:PTFCDOFLOPIGGS-UHFFFAOYSA-N",
      "detail": "379 source sites have context-unresolved roles"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "INCHIKEY:LZXLHLSTUPFULX-UHFFFAOYSA-N",
      "detail": "source conflict retained; original verification pending"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:DEFREITAS2021_1",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:COLLIE2025_11",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:COLLIE2025_12",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:COLLIE2025_13",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:COLLIE2025_5",
      "detail": "chemical identity / preparation unresolved"
    },
    {
      "code": "profile_requires_scientific_review",
      "severity": "review",
      "subject_id": "PREP:COLLIE2025_6",
      "detail": "chemical identity / preparation unresolved"
    }
  ],
  "limitations": [
    "Phase5 structural annotations reclassified, not independently re-refined",
    "Partial/inaccessible primary-source details retain original uncertainty",
    "No assertion of ligand potency from structure",
    "No Phase6B candidate promotion"
  ]
}