Scientific evidence classification · Phase 6A preserved + Phase 6B additions

PWWP Compounds
& Bioactivity

Explore experimentally studied preparations separately from deposited research ligands, buffers, ions and unresolved chemical evidence. Every role is source- and target-context specific.

Explore studied compounds Structural & Binding Landscape →

Different denominators · 26 October 2026

38studied preparation profiles · 26 baseline + 12 new

109profiles with PWWP research-ligand geometry

93source assay / association observations · 80 baseline + 13 new

Combined Phase 6A + Phase 6B denominators. These groups overlap; the 109 structurally source-tagged research ligands are unchanged. Deposited components and reagents are not automatically biochemical binders.

Search compounds & identifiersProteinEvidence view

Specific PWWP domainExact PWWP-proximal deposited siteChemical identity

Assay, source & experimental-context filters

Assay method Endpoint Reported relation Exact concentration min (µM)Exact concentration max (µM) Publication / source databasePublication yearAssay organismTested constructVerification status / scope Missing experimental detailAny associated PDB structure Inventory scopeSort

Assay filters must match the same observation. Concentration ranges require one endpoint and exact positive measurements; inequalities and qualitative findings remain searchable separately.

Evidence classification · exact source records

11 matching profiles

19 matching assay / association observations. Counts here are profiles, not unique assay events or deposited ligand instances; views overlap.

Export assay CSV Export evidence JSON

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 1 (de Freitas 2021)

NSD2

SPR Kd= 41 ± 8 µMOne source observation · PMID:33522809

2 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 11 (Collie 2025)

NSD2NSD3

SPR Kd= 1.02 ± 0.19 µMOne source observation · PMID:40959233

2 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 12 (Collie 2025)

NSD2NSD3

SPR Kd= 1.47 ± 0.13 µMOne source observation · PMID:40959233

3 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 13 (Collie 2025)

NSD2NSD3

SPR Kd= 0.75 ± 0.04 µMOne source observation · PMID:40959233

3 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 5 (Collie 2025)

NSD2NSD3

SPR Kd= 0.16 ± 0.03 µMOne source observation · PMID:40959233

2 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

compound 6 (Collie 2025)

NSD2NSD3

SPR Kd= 0.71 ± 0.09 µMOne source observation · PMID:40959233

3 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Identity / evidence review pending

HS13

NSD2

Source verification is pending.

1 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

UNC8269

NSD2

SPR Kd= 36 ± 21 nMOne source observation · PMID:38965384

1 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligand

UNC8325

NSD2

SPR Kd= 41 ± 19 nMOne source observation · PMID:38965384

1 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Experimental preparationIdentity not assigned

Measurements remain attached to the reported preparation.

Studied · no deposited PWWP research ligandExperiment-specific control

UNC8884

NSD2

No source-curated measured assay in this context. Structural evidence is shown separately.

1 matching observations0 PWWP research-ligand PDB entries

Unresolved preparation · individual modeled components do not inherit its potency.

Identity, assays & sources

Source identityDepiction not verified

Source SMILES and full InChIKey require reconciliation.

Deposited research ligand · no curated assay

4-[[cyclopropyl-[(~{Z})-2-methyl-4-(5-oxidanylidene-2~{H}-1,4-oxazin-3-yl)but-3-enoyl]amino]methyl]-~{N}-[3-[2-[[4-(hydroxymethyl)phenyl]carbonyl-methyl-amino]ethyl]phenyl]benzamide

NSD2

Source verification is pending.

0 matching observations1 PWWP research-ligand PDB entries

Identity, assays & sources

PWWP Compounds& Bioactivity

11 matching profiles

PWWP Compounds
& Bioactivity