Studied + deposited research ligandReported probe
UNC6934
NSD2NSD3
SPR Kd= 91 ± 8 nMOne source observation · PMID:34782742
5 matching observations1 PWWP research-ligand PDB entries
Scientific evidence classification · Phase 6A preserved + Phase 6B additions
PWWP Compounds
& Bioactivity
Explore experimentally studied preparations separately from deposited research ligands, buffers, ions and unresolved chemical evidence. Every role is source- and target-context specific.
Different denominators · 26 October 2026
38studied preparation profiles · 26 baseline + 12 new
109profiles with PWWP research-ligand geometry
93source assay / association observations · 80 baseline + 13 new
Combined Phase 6A + Phase 6B denominators. These groups overlap; the 109 structurally source-tagged research ligands are unchanged. Deposited components and reagents are not automatically biochemical binders.
Evidence classification · exact source records
31 matching profiles
34 matching assay / association observations. Counts here are profiles, not unique assay events or deposited ligand instances; views overlap.
Identity, assays & sources
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 1 (de Freitas 2021)
NSD2
SPR Kd= 41 ± 8 µMOne source observation · PMID:33522809
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 11 (Collie 2025)
NSD2NSD3
SPR Kd= 1.02 ± 0.19 µMOne source observation · PMID:40959233
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 12 (Collie 2025)
NSD2NSD3
SPR Kd= 1.47 ± 0.13 µMOne source observation · PMID:40959233
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 13 (Collie 2025)
NSD2NSD3
SPR Kd= 0.75 ± 0.04 µMOne source observation · PMID:40959233
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 5 (Collie 2025)
NSD2NSD3
SPR Kd= 0.16 ± 0.03 µMOne source observation · PMID:40959233
2 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
compound 6 (Collie 2025)
NSD2NSD3
SPR Kd= 0.71 ± 0.09 µMOne source observation · PMID:40959233
3 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Studied + deposited research ligand
compound 7 (Collie 2025)
NSD2NSD3
SPR Kd= 0.15 ± 0.02 µMOne source observation · PMID:40959233
3 matching observations1 PWWP research-ligand PDB entries
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Identity / evidence review pending
HS13
NSD2
Source verification is pending.
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Studied + deposited research ligand
MR837 (3f)
NSD2
SPR Kd= 7 ± 3 µMOne source observation · PMID:33522809
2 matching observations1 PWWP research-ligand PDB entries
Studied + deposited research ligand
MRT866
NSD2
SPR Kd= 349 ± 19 nMOne source observation · PMID:34782742
1 matching observations2 PWWP research-ligand PDB entries
Studied · no deposited PWWP research ligand
UNC7096
NSD2
SPR Kd= 46 nMOne source observation · PMID:34782742
1 matching observations0 PWWP research-ligand PDB entries
Studied · no deposited PWWP research ligandExperiment-specific control
UNC7145
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
1 matching observations0 PWWP research-ligand PDB entries
Studied · no deposited PWWP research ligand
UNC8153
NSD2
SPR Kd= 24 ± 7 nMOne source observation · PMID:36976643
1 matching observations0 PWWP research-ligand PDB entries
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
UNC8269
NSD2
SPR Kd= 36 ± 21 nMOne source observation · PMID:38965384
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligand
UNC8325
NSD2
SPR Kd= 41 ± 19 nMOne source observation · PMID:38965384
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
Studied · no deposited PWWP research ligand
UNC8732
NSD2
SPR Kd= 76 ± 4 nMOne source observation · PMID:38965384
1 matching observations0 PWWP research-ligand PDB entries
Experimental preparationIdentity not assigned
Measurements remain attached to the reported preparation.
Studied · no deposited PWWP research ligandExperiment-specific control
UNC8884
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
1 matching observations0 PWWP research-ligand PDB entries
Unresolved preparation · individual modeled components do not inherit its potency.
![Verified 2D molecular structure of (2S)-1-[4-[[(3R)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide](/compounds/depiction/0a262befb369d4ee0287-light.svg)
![Verified 2D molecular structure of (2S)-1-[4-[[(3R)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide](/compounds/depiction/0a262befb369d4ee0287-dark.svg)
Deposited research ligand · no curated assay
(2S)-1-[4-[[(3R)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of (2S)-1-[4-[[(3S)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide](/compounds/depiction/baa8ac5817f9f50c15af-light.svg)
![Verified 2D molecular structure of (2S)-1-[4-[[(3S)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide](/compounds/depiction/baa8ac5817f9f50c15af-dark.svg)
Deposited research ligand · no curated assay
(2S)-1-[4-[[(3S)-1,1-bis(oxidanylidene)thiolan-3-yl]methyl-methyl-amino]-6-methyl-pyrimidin-2-yl]-N-methyl-pyrrolidine-2-carboxamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
Deposited research ligand · no curated assay
(6R)-6-(3,5-dichlorophenyl)morpholin-3-one
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
Deposited research ligand · no curated assay
(Z)-N-methyl-3-sulfanyl-prop-2-enamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of 1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione](/compounds/depiction/b73cfe57eabe372da74e-light.svg)
![Verified 2D molecular structure of 1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione](/compounds/depiction/b73cfe57eabe372da74e-dark.svg)
Deposited research ligand · no curated assay
1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile](/compounds/depiction/ca5b2ddaf0e2a46c0f12-light.svg)
![Verified 2D molecular structure of 4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile](/compounds/depiction/ca5b2ddaf0e2a46c0f12-dark.svg)
Deposited research ligand · no curated assay
4-[5-[4-(aminomethyl)-2,6-dimethoxy-phenyl]-3-methyl-imidazol-4-yl]benzenecarbonitrile
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
Source identityDepiction not verified
Source SMILES and full InChIKey require reconciliation.
Deposited research ligand · no curated assay
4-[[cyclopropyl-[(~{Z})-2-methyl-4-(5-oxidanylidene-2~{H}-1,4-oxazin-3-yl)but-3-enoyl]amino]methyl]-~{N}-[3-[2-[[4-(hydroxymethyl)phenyl]carbonyl-methyl-amino]ethyl]phenyl]benzamide
NSD2
Source verification is pending.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of 4-methyl-3-[1-methyl-5-(3-oxidanylidene-4~{H}-1,4-benzoxazin-7-yl)imidazol-4-yl]-~{N}-phenyl-benzamide](/compounds/depiction/a578d43c942507209461-light.svg)
![Verified 2D molecular structure of 4-methyl-3-[1-methyl-5-(3-oxidanylidene-4~{H}-1,4-benzoxazin-7-yl)imidazol-4-yl]-~{N}-phenyl-benzamide](/compounds/depiction/a578d43c942507209461-dark.svg)
Deposited research ligand · no curated assay
4-methyl-3-[1-methyl-5-(3-oxidanylidene-4~{H}-1,4-benzoxazin-7-yl)imidazol-4-yl]-~{N}-phenyl-benzamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of 7-[3-methyl-5-[2-methyl-5-[(pyridin-3-ylamino)methyl]phenyl]imidazol-4-yl]-4~{H}-1,4-benzoxazin-3-one](/compounds/depiction/45b68058cab2707d148a-light.svg)
![Verified 2D molecular structure of 7-[3-methyl-5-[2-methyl-5-[(pyridin-3-ylamino)methyl]phenyl]imidazol-4-yl]-4~{H}-1,4-benzoxazin-3-one](/compounds/depiction/45b68058cab2707d148a-dark.svg)
Deposited research ligand · no curated assay
7-[3-methyl-5-[2-methyl-5-[(pyridin-3-ylamino)methyl]phenyl]imidazol-4-yl]-4~{H}-1,4-benzoxazin-3-one
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of 7-[5-methyl-3-[2-methyl-5-(piperidin-1-ylmethyl)phenyl]-1,2-oxazol-4-yl]-4~{H}-1,4-benzoxazin-3-one](/compounds/depiction/18f1bcef217c83788503-light.svg)
![Verified 2D molecular structure of 7-[5-methyl-3-[2-methyl-5-(piperidin-1-ylmethyl)phenyl]-1,2-oxazol-4-yl]-4~{H}-1,4-benzoxazin-3-one](/compounds/depiction/18f1bcef217c83788503-dark.svg)
Deposited research ligand · no curated assay
7-[5-methyl-3-[2-methyl-5-(piperidin-1-ylmethyl)phenyl]-1,2-oxazol-4-yl]-4~{H}-1,4-benzoxazin-3-one
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
Deposited research ligand · no curated assay
N-(2-methoxyphenyl)-2-selanyl-benzamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
Deposited research ligand · no curated assay
~{N}-(4-aminophenyl)-2-selanyl-benzamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations1 PWWP research-ligand PDB entries
![Verified 2D molecular structure of ~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide](/compounds/depiction/4797066c0d81deced663-light.svg)
![Verified 2D molecular structure of ~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide](/compounds/depiction/4797066c0d81deced663-dark.svg)
Deposited research ligand · no curated assay
~{N}-cyclopropyl-~{N}-[[4-[[2-(6-oxidanylhexanoyl)-1~{H}-isoquinolin-6-yl]carbamoyl]phenyl]methyl]-3-oxidanylidene-4~{H}-1,4-benzoxazine-7-carboxamide
NSD2
No source-curated measured assay in this context. Structural evidence is shown separately.
0 matching observations2 PWWP research-ligand PDB entries