Scientific evidence classification · Phase 6A preserved + Phase 6B additions

PWWP Compounds
& Bioactivity

Explore experimentally studied preparations separately from deposited research ligands, buffers, ions and unresolved chemical evidence. Every role is source- and target-context specific.

Explore studied compounds Structural & Binding Landscape →

Different denominators · 26 October 2026

38studied preparation profiles · 26 baseline + 12 new

109profiles with PWWP research-ligand geometry

93source assay / association observations · 80 baseline + 13 new

Combined Phase 6A + Phase 6B denominators. These groups overlap; the 109 structurally source-tagged research ligands are unchanged. Deposited components and reagents are not automatically biochemical binders.

Search compounds & identifiersProteinEvidence view

Specific PWWP domainExact PWWP-proximal deposited siteChemical identity

Assay, source & experimental-context filters

Assay method Endpoint Reported relation Exact concentration min (µM)Exact concentration max (µM) Publication / source databasePublication yearAssay organismTested constructVerification status / scope Missing experimental detailAny associated PDB structure Inventory scopeSort

Assay filters must match the same observation. Concentration ranges require one endpoint and exact positive measurements; inequalities and qualitative findings remain searchable separately.

Phase 6B · source-reviewed additions (separate from the Phase 6A snapshot)

2 matching new observations · 1 preparations

Keep source-level IC50, Kd, and whole-protein DC50 separate; these records were not included in the original 80.

Filter all Phase 6B assay contexts

Preparation	Target scope	Original assay	Primary source
UNC10088	NSD2 PWWP1, exact domain	IC50 =248 ± 22 nM TR-FRET competitive displacement of biotinylated UNC7096	10.1038/s41467-026-72235-9 Figure 2h and Supplementary Figure 3D
UNC10088	NSD2 PWWP1, exact domain	IC50 =101 ± 8 nM TR-FRET competitive displacement of biotinylated UNC7096	10.1038/s41467-026-72235-9 Figure 2h, Supplementary Figure 3D and Results

Evidence classification · exact source records

17 matching profiles

33 matching assay / association observations. Counts here are profiles, not unique assay events or deposited ligand instances; views overlap.

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Verified 2D molecular structure of UNC6934

Studied + deposited research ligandReported probe

UNC6934

NSD2NSD3

SPR Kd= 91 ± 8 nMOne source observation · PMID:34782742

5 matching observations1 PWWP research-ligand PDB entries

PWWP Compounds& Bioactivity

2 matching new observations · 1 preparations

17 matching profiles

PWWP Compounds
& Bioactivity