Comparative binding sites

Family-wide research evidence

The frozen 39-instance PWWP evolutionary alignment contains 27 domains with at least one observed experimental core and six domains with source-classified deposited research-ligand sites. These totals are not counts of independent ligand-binding experiments. The comparative family gap inventory distinguishes absence of recorded experimental structural evidence from absent biochemical evidence.

Explore domain-level research gaps

Reproducibility and research questions

Original 230 historical mmCIF coordinate files are unchanged. The Phase 6D analysis independently measured 111 ligand-bearing structures and examined 18 representative domains across the family. Native residue identity, experimentally mapped core completeness, source-deposited ligand geometry and literature biochemical evidence remain separately sourced.