Experimental coordinates · Exact deposited instances
Ligand contacts & pocket quality
Inspect the atoms that are present, the residues that are missing, and the precise scope of each chemical association.
Phase 6C historical atom / receptor assessment Phase 6C.1 full-atom experimental quality inventory
Full-coordinate Phase 6C.1 atom and ligand environment assessment
Load the checksum-verified original coordinates to explore the selected chain and ligand.
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Atom completeness · selected chain and annotation core
What can these coordinates support?
A fully observed annotation core is not a complete-receptor certification. Short annotation intervals, absent peripheral residues, alternate conformers and unexamined density can limit structural interpretation. No receptor preparation was performed.
Frozen 5 Å heavy-atom proximity observations
Contacting residues · M3L
Heavy-atom distances use the first deposited model and asymmetric unit, occupancy >0 and retained alternate locations. No symmetry expansion or affinity inference. Proximity alone is not evidence of affinity or a functional interaction.
| Canonical residue | Deposited residue | Scope | Minimum distance | Atom quality | Inspect |
|---|---|---|---|---|---|
| MET 19 | B:19 · entity 20 · label B | annotation core | 4.1018 Å | Unassessed | |
| TYR 22 | B:22 · entity 23 · label B | annotation core | 3.3813 Å | Unassessed | |
| TRP 25 | B:25 · entity 26 · label B | annotation core | 3.6311 Å | Unassessed | |
| PHE 48 | B:48 · entity 49 · label B | annotation core | 3.7323 Å | Unassessed | |
| THR 51 | B:51 · entity 52 · label B | annotation core | 3.6190 Å | Unassessed | |
| GLU 53 | B:53 · entity 54 · label B | annotation core | 3.1451 Å | Unassessed | |
| THR 54 | B:54 · entity 55 · label B | annotation core | 3.0698 Å | Unassessed | |
| ALA 55 | B:55 · entity 56 · label B | annotation core | 3.4972 Å | Unassessed |
Identity, native target and exact site links
Linked experimental assays
| Measured preparation | Method / endpoint | Original observation | Tested construct | Evidence |
|---|---|---|---|---|
| No exact site-to-assay link is established in the frozen evidence graph. Visit the domain's Ligands & Bioactivity section for newly curated or structure-free observations. | ||||
Filterable structural assessment inventory
Coordinate coverage & quality
| PDB / chain | Domain | Core Cα coverage | PWWP-contact ligand instances | Atom assessment | Missing core heavy atoms |
|---|---|---|---|---|---|
| 6IIP · A | HDGFL3 PWWP1 | 58 / 58 | 7 | Unassessed | — |
| 6IIP · B | HDGFL3 PWWP1 | 58 / 58 | 5 | Unassessed | — |
| 6IIQ · A | HDGFL3 PWWP1 | 58 / 58 | 2 | Unassessed | — |
| 6IIQ · B | HDGFL3 PWWP1 | 58 / 58 | 2 | Unassessed | — |
| 6IIQ · C | HDGFL3 PWWP1 | 58 / 58 | 2 | Unassessed | — |
| 6IIR · A | HDGFL3 PWWP1 | 58 / 58 | 0 | Unassessed | — |
| 6IIR · B | HDGFL3 PWWP1 | 58 / 58 | 0 | Unassessed | — |
| 6IIS · A | HDGFL3 PWWP1 | 58 / 58 | 1 | Unassessed | — |
| 6IIS · B | HDGFL3 PWWP1 | 58 / 58 | 1 | Unassessed | — |
| 6IIT · A | HDGFL3 PWWP1 | 58 / 58 | 0 | Unassessed | — |
| 6IIT · B | HDGFL3 PWWP1 | 58 / 58 | 0 | Unassessed | — |
Source bytes, methods and provenance
Detailed atom completeness only for the three packaged original-coordinate files; quality uses observed atom-name union across positive-occupancy alternate conformers, with per-alt differences retained. Missing entire residues are separate. Nonstandard amino-acid templates are unassessed. No density reinterpretation, receptor repair, docking or MD.
Coordinate SHA-256: 87a30acd3052d34ac9ebd481ad1e90164d57cd7273824da890709d3d9cdb2749
Source PDB: https://www.rcsb.org/structure/6IIS. Original coordinate file: mmCIF. Original annotation and contact calculations are retained unchanged; the additional completeness assessment is PWWP_POCKET_QUALITY_1.0.0.
Methods and reproducible builder are included under analysis/phase5_pockets and scripts/build_phase5_pockets.py in the downloadable release.