{ "analysis_id": "PWWP_POCKET_QUALITY_1.0.0", "source_snapshot": "frozen Atlas v1.2", "investigated_utc_date": "2026-10-26", "no_observed_core_entries": [ { "pdb_id": "6PA7", "title": "The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome.", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/6PA7", "coordinate_sha256": "79215faaf437b7575076343815034f0af7341748b6b312143a0274192b0c57bb", "domains": [ "UP:Q9UBC3:PWWP1", "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A", "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "L", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 770 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "M", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "N", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 770 ] ], "core": [ 225, 283 ] } ] }, { "pdb_id": "7CRO", "title": "NSD2 bearing E1099K/T1150A dual mutation in complex with 187-bp NCP", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7CRO", "coordinate_sha256": "c21f8296fe4e521dd029b2570dd15206edae2bf288f41906bf0884bc5a821797", "domains": [ "UP:O96028:PWWP2" ], "genes": [ "NSD2" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:O96028:PWWP2", "mapped_construct_ranges": [ [ 661, 1365 ] ], "core": [ 880, 942 ] } ] }, { "pdb_id": "7CRP", "title": "NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode)", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7CRP", "coordinate_sha256": "f5b2c1c584db9401870e945c21c05fdf01526b726d1ca826ad6f15ae75b75581", "domains": [ "UP:Q9BZ95:PWWP2" ], "genes": [ "NSD3" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9BZ95:PWWP2", "mapped_construct_ranges": [ [ 680, 1437 ] ], "core": [ 960, 1022 ] } ] }, { "pdb_id": "7CRQ", "title": "NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode)", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7CRQ", "coordinate_sha256": "ef981cf1834da5726efb4e02ec23dbccea1a2bc4475f1adbcad094fb4f5349c1", "domains": [ "UP:Q9BZ95:PWWP2" ], "genes": [ "NSD3" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9BZ95:PWWP2", "mapped_construct_ranges": [ [ 680, 1437 ] ], "core": [ 960, 1022 ] }, { "label_asym_id": "L", "domain_id": "UP:Q9BZ95:PWWP2", "mapped_construct_ranges": [ [ 680, 1437 ] ], "core": [ 960, 1022 ] } ] }, { "pdb_id": "7CRR", "title": "Native NSD3 bound to 187-bp nucleosome", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7CRR", "coordinate_sha256": "484f198eaff6ccb592cb4f671110a7e37421871745f1acc60198e760694b77cc", "domains": [ "UP:Q9BZ95:PWWP2" ], "genes": [ "NSD3" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9BZ95:PWWP2", "mapped_construct_ranges": [ [ 680, 1437 ] ], "core": [ 960, 1022 ] } ] }, { "pdb_id": "7OUF", "title": "Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor XZ450", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7OUF", "coordinate_sha256": "d1d5b10a80bf04fa28b7d5e4f22531e51205f1d4226ad17c729efe118990afd1", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "C", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "H", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] } ] }, { "pdb_id": "7OUG", "title": "STLV-1 intasome:B56 in complex with the strand-transfer inhibitor raltegravir", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7OUG", "coordinate_sha256": "1a9dc18e5d7c8ac9cb3ee7a8db30ebb83d3851e9d219270c97d93c5e8bb1d477", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "C", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "H", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] } ] }, { "pdb_id": "7OUH", "title": "Structure of the STLV intasome:B56 complex bound to the strand-transfer inhibitor bictegravir", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7OUH", "coordinate_sha256": "9e688e82a7d82ab55dc27c7cbb8efb132a20d021d900b98f432605914d0f7ff0", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "C", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "H", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] } ] }, { "pdb_id": "7PEL", "title": "CryoEM structure of simian T-cell lymphotropic virus intasome in complex with PP2A regulatory subunit B56 gamma", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/7PEL", "coordinate_sha256": "99ff3b79b6bde07b27e08ea5808aa6cfa1b2072c88c546bd81b1016a97f92742", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "C", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "H", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 325 ] ], "core": [ 1, 64 ] } ] }, { "pdb_id": "8AG6", "title": "human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/8AG6", "coordinate_sha256": "79002d73409d46aad2eddf9c662ec0dee6e97c3431e9b2f89f79a28f6bccc802", "domains": [ "UP:P52701:PWWP1" ], "genes": [ "MSH6" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "B", "domain_id": "UP:P52701:PWWP1", "mapped_construct_ranges": [ [ 2, 1360 ] ], "core": [ 92, 154 ] } ] }, { "pdb_id": "8EII", "title": "Cryo-EM structure of human DNMT3B homo-tetramer (form II)", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/8EII", "coordinate_sha256": "5035b50d97c6361eeec23854535f33b7f8dfc997bdf34bb2665fededdf1c19bd", "domains": [ "UP:Q9UBC3:PWWP1" ], "genes": [ "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "B", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "C", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "D", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] } ] }, { "pdb_id": "8EIJ", "title": "Cryo-EM structure of human DNMT3B homo-trimer", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/8EIJ", "coordinate_sha256": "3d60777b8072dfea238e6167ece0d82a55cb1911b5d14a5ca7c28bb310c9233e", "domains": [ "UP:Q9UBC3:PWWP1" ], "genes": [ "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "B", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "C", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] } ] }, { "pdb_id": "8EIK", "title": "Cryo-EM structure of human DNMT3B homo-hexamer", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/8EIK", "coordinate_sha256": "b3fff6d453f5904930be422eada40aa426a93990f169f4aeae23fcaa6f781c0d", "domains": [ "UP:Q9UBC3:PWWP1" ], "genes": [ "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "B", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "C", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "D", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "E", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "F", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 206, 853 ] ], "core": [ 225, 283 ] } ] }, { "pdb_id": "8QZM", "title": "Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/8QZM", "coordinate_sha256": "df338d612b7680fe4107c27eea6fcefaa8cdfa4e191d355742c1661eab55c7fe", "domains": [ "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 1, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9E00", "title": "Cryo-EM structure of human DNMT3A2-DNMT3B3 complex bound to di-nucleosome", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9E00", "coordinate_sha256": "01318429b9a7c29f14772a47afaec906a05fa64cc76271d5e88bc4d3f735ea10", "domains": [ "UP:Q9UBC3:PWWP1", "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A", "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "S", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "T", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "U", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "V", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "W", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "X", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "Y", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "Z", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9E2Q", "title": "Cryo-EM structure of DNMT 3A2/3B3 tetramer in complex with a di-nucleosome with a six base pair linker", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9E2Q", "coordinate_sha256": "b93d31035b4ecb733c69c2b502a6046bfde064c27a7e6531db679531f6b87252", "domains": [ "UP:Q9UBC3:PWWP1", "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A", "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "S", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "T", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "U", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "V", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "W", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "X", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "Y", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "Z", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9E3R", "title": "Cryo-EM structure of PWWP domain deleted DNMT 3A2/3B3 in complex with a di-nucleosome", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9E3R", "coordinate_sha256": "e20236157e455f0ed53454126dee5e80ed0b521ded2490fc76a18a61900c3d05", "domains": [ "UP:Q9UBC3:PWWP1", "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A", "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": "Deposited title reports PWWP deletion while frozen mapped ranges overlap the annotated core; retain both and verify the actual construct before interpretation.", "mapped_chains": [ { "label_asym_id": "S", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "T", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "U", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "V", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "W", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "X", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "Y", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "Z", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9E3U", "title": "Cryo-EM structure of DNMT 3A2/3B3 tetramer bound to a di-nucleosome with a 25 base-pair linker", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9E3U", "coordinate_sha256": "75ed1a514fc1477e26591b82cf0dea6f4002dc535885aee1a2631cb52f9acead", "domains": [ "UP:Q9UBC3:PWWP1", "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A", "DNMT3B" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "I", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "L", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "M", "domain_id": "UP:Q9UBC3:PWWP1", "mapped_construct_ranges": [ [ 1, 393 ], [ 414, 790 ] ], "core": [ 225, 283 ] }, { "label_asym_id": "N", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "O", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9LQ1", "title": "Structure of human DNMT3A-TCL1A complex", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9LQ1", "coordinate_sha256": "ff559ef574bf8cfb35dd3505de2691ab2f1530c37785d7eb2d079817963acbf5", "domains": [ "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 1, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "D", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 1, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9MP0", "title": "The cryo-EM structure of the human DNA methyltransferases DNMT3A2 and DNMT3L dodecamer", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9MP0", "coordinate_sha256": "bdd61f49181bc06c097b520c53fcb026f13b3cd9ecd0edf642fd5178aa8998ac", "domains": [ "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "B", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "C", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "D", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "E", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "F", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "G", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "H", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9MPO", "title": "The cryo-EM structure of the human DNA methyltransferase DNMT3A2 and DNMT3L octamer", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9MPO", "coordinate_sha256": "f202338a40a7a38d3849c1f042a66f42373656578fe6d3b0f57a4b58ce016547", "domains": [ "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "A", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "B", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "C", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "D", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "E", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "F", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9MPP", "title": "The cryo-EM structure of nucleosome-bound DNA methyltransferases DNMT3A2 and DNMT3L", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9MPP", "coordinate_sha256": "04eda55f070595fabeb1e0a3af9f67889aa059346f1aed2112cbcd101e6bbc07", "domains": [ "UP:Q9Y6K1:PWWP1" ], "genes": [ "DNMT3A" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "K", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] }, { "label_asym_id": "M", "domain_id": "UP:Q9Y6K1:PWWP1", "mapped_construct_ranges": [ [ 224, 912 ] ], "core": [ 292, 350 ] } ] }, { "pdb_id": "9S28", "title": "MVV STC intasome in complex with LEDGF", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9S28", "coordinate_sha256": "c8a0459fd824bdb5a120300f3cdb13aed128cd0323cb258e5eac70b0ce6266b1", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "Q", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "R", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "S", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "T", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "U", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "V", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "W", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "X", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "Y", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "Z", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] } ] }, { "pdb_id": "9S29", "title": "MVV CSC intasome in complex with LEDGF", "method": [ "ELECTRON MICROSCOPY" ], "source_url": "https://www.rcsb.org/structure/9S29", "coordinate_sha256": "0ace05400aa2f20d078c377b6deca956eb5f7f2fde8c805e5ed1006057ca859b", "domains": [ "UP:O75475:PWWP1" ], "genes": [ "PSIP1" ], "interpretation": "Protein association and mapped construct overlap do not establish observed PWWP-core coordinates.", "source_conflict": null, "mapped_chains": [ { "label_asym_id": "AA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "BA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "CA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "DA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "EA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "FA", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "K", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "L", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "M", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "N", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "O", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] }, { "label_asym_id": "P", "domain_id": "UP:O75475:PWWP1", "mapped_construct_ranges": [ [ 1, 530 ] ], "core": [ 1, 64 ] } ] } ], "human_domains_without_observed_core": [ { "domain_id": "UP:Q4LE39:PWWP1", "protein_id": "UP:Q4LE39", "gene": "ARID4B", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 170, "end": 262, "length": 93, "source": "pfam via InterPro API", "evidence": "[{\"source\":\"pfam\",\"identifier\":\"PF08169\",\"name\":\"RBB1NT (NUC162) domain\",\"start\":170,\"end\":262,\"score\":3.1e-33,\"model\":\"PF08169\",\"representative\":false,\"integrated_identifier\":\"IPR012603\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q4LE39/?page_size=200\"}]", "identifiers": "[\"IPR012603\",\"PF08169\"]", "alternative_annotations": "[{\"source\":\"interpro\",\"identifier\":\"IPR012603\",\"name\":\"ARID4A/B, PWWP domain\",\"start\":170,\"end\":262,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q4LE39/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF08169\",\"name\":\"RBB1NT (NUC162) domain\",\"start\":170,\"end\":262,\"score\":3.1e-33,\"model\":\"PF08169\",\"representative\":false,\"integrated_identifier\":\"IPR012603\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q4LE39/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q4LE39-F1:v6", "n_domain_CA": 93, "core_mean_plddt": 85.937 }, { "domain_id": "UP:Q49A26:PWWP1", "protein_id": "UP:Q49A26", "gene": "GLYR1", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 8, "end": 66, "length": 59, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"IPR035501\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd05836\"]", "alternative_annotations": "[{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":6,\"end\":64,\"score\":1.5e-14,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":6,\"end\":88,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR035501\",\"name\":\"Cytokine-like nuclear factor N-PAC, PWWP domain\",\"start\":6,\"end\":90,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"},{\"source\":\"cdd\",\"identifier\":\"cd05836\",\"name\":\"PWWP domain found in glyoxylate reductase 1 (GLYR1) and similar proteins\",\"start\":6,\"end\":90,\"score\":4.28758e-49,\"model\":\"cd05836\",\"representative\":false,\"integrated_identifier\":\"IPR035501\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":8,\"end\":66,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":9,\"end\":88,\"score\":1.7e-16,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q49A26/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q49A26-F1:v6", "n_domain_CA": 59, "core_mean_plddt": 87.8546 }, { "domain_id": "UP:Q5TGJ6:PWWP1", "protein_id": "UP:Q5TGJ6", "gene": "HDGFL1", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 11, "end": 62, "length": 52, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PF00855\",\"PS50812\",\"SM00293\"]", "alternative_annotations": "[{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":9,\"end\":60,\"score\":1.3e-16,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5TGJ6/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":9,\"end\":85,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5TGJ6/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":11,\"end\":62,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5TGJ6/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":12,\"end\":85,\"score\":5.2e-10,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5TGJ6/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q5TGJ6-F1:v6", "n_domain_CA": 52, "core_mean_plddt": 93.5337 }, { "domain_id": "UP:Q15652:PWWP1", "protein_id": "UP:Q15652", "gene": "JMJD1C", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 81, "end": 179, "length": 99, "source": "pfam via InterPro API", "evidence": "[{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":81,\"end\":179,\"score\":2.4e-26,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q15652/?page_size=200\"}]", "identifiers": "[\"IPR054504\",\"PF22988\"]", "alternative_annotations": "[{\"source\":\"interpro\",\"identifier\":\"IPR054504\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":81,\"end\":179,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q15652/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":81,\"end\":179,\"score\":2.4e-26,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q15652/?page_size=200\"}]", "membership_tier": "predicted_PWWP_like", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q15652-F1:v6", "n_domain_CA": 99, "core_mean_plddt": 76.3837 }, { "domain_id": "UP:Q9Y4C1:PWWP1", "protein_id": "UP:Q9Y4C1", "gene": "KDM3A", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 88, "end": 177, "length": 90, "source": "pfam via InterPro API", "evidence": "[{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":88,\"end\":177,\"score\":2.3e-18,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9Y4C1/?page_size=200\"}]", "identifiers": "[\"IPR054504\",\"PF22988\"]", "alternative_annotations": "[{\"source\":\"interpro\",\"identifier\":\"IPR054504\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":88,\"end\":177,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9Y4C1/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":88,\"end\":177,\"score\":2.3e-18,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9Y4C1/?page_size=200\"}]", "membership_tier": "predicted_PWWP_like", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q9Y4C1-F1:v6", "n_domain_CA": 90, "core_mean_plddt": 80.6653 }, { "domain_id": "UP:Q7LBC6:PWWP1", "protein_id": "UP:Q7LBC6", "gene": "KDM3B", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 90, "end": 188, "length": 99, "source": "pfam via InterPro API", "evidence": "[{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":90,\"end\":188,\"score\":1.7e-23,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q7LBC6/?page_size=200\"}]", "identifiers": "[\"IPR054504\",\"PF22988\"]", "alternative_annotations": "[{\"source\":\"interpro\",\"identifier\":\"IPR054504\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":90,\"end\":188,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q7LBC6/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF22988\",\"name\":\"Lysine-specific demethylase 3B, PWWP domain\",\"start\":90,\"end\":188,\"score\":1.7e-23,\"model\":\"PF22988\",\"representative\":true,\"integrated_identifier\":\"IPR054504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q7LBC6/?page_size=200\"}]", "membership_tier": "predicted_PWWP_like", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q7LBC6-F1:v6", "n_domain_CA": 99, "core_mean_plddt": 83.4234 }, { "domain_id": "UP:Q9P267:PWWP1", "protein_id": "UP:Q9P267", "gene": "MBD5", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 1385, "end": 1409, "length": 25, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PS50812\",\"cd20141\"]", "alternative_annotations": "[{\"source\":\"cdd\",\"identifier\":\"cd20141\",\"name\":\"PWWP domain found in methyl-CpG-binding domain protein 5 (MBD5) and similar proteins\",\"start\":1383,\"end\":1466,\"score\":6.98744e-47,\"model\":\"cd20141\",\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9P267/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":1385,\"end\":1409,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9P267/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":1385,\"end\":1409,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9P267/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q9P267-F1:v6", "n_domain_CA": 25, "core_mean_plddt": 76.1952 }, { "domain_id": "UP:Q96L73:PWWP1", "protein_id": "UP:Q96L73", "gene": "NSD1", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 323, "end": 388, "length": 66, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd20161\"]", "alternative_annotations": "[{\"source\":\"cdd\",\"identifier\":\"cd20161\",\"name\":\"first PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins\",\"start\":318,\"end\":433,\"score\":5.40244e-74,\"model\":\"cd20161\",\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":321,\"end\":387,\"score\":0.0018,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":321,\"end\":408,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":323,\"end\":388,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":324,\"end\":408,\"score\":7.9e-09,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q96L73-F1:v6", "n_domain_CA": 66, "core_mean_plddt": 85.9068 }, { "domain_id": "UP:Q96L73:PWWP2", "protein_id": "UP:Q96L73", "gene": "NSD1", "taxonomy_id": "9606", "domain_name": "PWWP2", "start": 1756, "end": 1818, "length": 63, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"IPR047423\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd20164\"]", "alternative_annotations": "[{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":1754,\"end\":1816,\"score\":1.6e-28,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":1754,\"end\":1845,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR047423\",\"name\":\"Nuclear receptor-binding SET domain-containing protein 1, second PWWP domain\",\"start\":1755,\"end\":1850,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"cdd\",\"identifier\":\"cd20164\",\"name\":\"second PWWP domain found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins\",\"start\":1755,\"end\":1850,\"score\":2.1929e-70,\"model\":\"cd20164\",\"representative\":false,\"integrated_identifier\":\"IPR047423\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":1756,\"end\":1818,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":1758,\"end\":1845,\"score\":1.1e-18,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96L73/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q96L73-F1:v6", "n_domain_CA": 63, "core_mean_plddt": 91.8644 }, { "domain_id": "UP:O96028:PWWP2", "protein_id": "UP:O96028", "gene": "NSD2", "taxonomy_id": "9606", "domain_name": "PWWP2", "start": 880, "end": 942, "length": 63, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"IPR047435\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd20165\"]", "alternative_annotations": "[{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":878,\"end\":940,\"score\":4.6e-23,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":878,\"end\":969,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR047435\",\"name\":\"Nuclear SET domain-containing protein 2, second PWWP domain\",\"start\":879,\"end\":974,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"},{\"source\":\"cdd\",\"identifier\":\"cd20165\",\"name\":\"second PWWP domain found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins\",\"start\":879,\"end\":974,\"score\":4.17223e-72,\"model\":\"cd20165\",\"representative\":false,\"integrated_identifier\":\"IPR047435\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":880,\"end\":942,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":882,\"end\":969,\"score\":8.5e-20,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/O96028/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 4, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-O96028-F1:v6", "n_domain_CA": 63, "core_mean_plddt": 89.8052 }, { "domain_id": "UP:Q96N64:PWWP1", "protein_id": "UP:Q96N64", "gene": "PWWP2A", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 655, "end": 715, "length": 61, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd20152\"]", "alternative_annotations": "[{\"source\":\"cdd\",\"identifier\":\"cd20152\",\"name\":\"PWWP domain found in PWWP domain-containing protein 2A (PWWP2A)\",\"start\":634,\"end\":755,\"score\":1.25499e-81,\"model\":\"cd20152\",\"representative\":true,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96N64/?page_size=200\"},{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":653,\"end\":713,\"score\":2.1e-06,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96N64/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":653,\"end\":739,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96N64/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":655,\"end\":715,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96N64/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":656,\"end\":739,\"score\":3.8e-09,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q96N64/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q96N64-F1:v6", "n_domain_CA": 61, "core_mean_plddt": 94.668 }, { "domain_id": "UP:Q5H9M0:PWWP1", "protein_id": "UP:Q5H9M0", "gene": "PWWP3B", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 392, "end": 453, "length": 62, "source": "UniProtKB reviewed feature", "evidence": "[]", "identifiers": "[\"IPR035504\",\"PF20884\",\"cd06080\"]", "alternative_annotations": "[{\"source\":\"pfam\",\"identifier\":\"PF20884\",\"name\":\"MUM1-like, PWWP domain\",\"start\":390,\"end\":469,\"score\":1e-40,\"model\":\"PF20884\",\"representative\":false,\"integrated_identifier\":\"IPR035504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5H9M0/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR035504\",\"name\":\"MUM1-like, PWWP domain\",\"start\":390,\"end\":479,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5H9M0/?page_size=200\"},{\"source\":\"cdd\",\"identifier\":\"cd06080\",\"name\":\"PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins\",\"start\":390,\"end\":479,\"score\":1.04734e-34,\"model\":\"cd06080\",\"representative\":false,\"integrated_identifier\":\"IPR035504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q5H9M0/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q5H9M0-F1:v6", "n_domain_CA": 62, "core_mean_plddt": 89.8427 }, { "domain_id": "UP:A0A494C071:PWWP1", "protein_id": "UP:A0A494C071", "gene": "PWWP4", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 1756, "end": 1817, "length": 62, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR035504\",\"PF20884\",\"cd06080\"]", "alternative_annotations": "[{\"source\":\"interpro\",\"identifier\":\"IPR035504\",\"name\":\"MUM1-like, PWWP domain\",\"start\":1754,\"end\":1841,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/A0A494C071/?page_size=200\"},{\"source\":\"cdd\",\"identifier\":\"cd06080\",\"name\":\"PWWP domain found in mutated melanoma-associated antigen 1 (MUM-1) and similar proteins\",\"start\":1754,\"end\":1841,\"score\":3.21906e-27,\"model\":\"cd06080\",\"representative\":false,\"integrated_identifier\":\"IPR035504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/A0A494C071/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF20884\",\"name\":\"MUM1-like, PWWP domain\",\"start\":1755,\"end\":1833,\"score\":1.9e-24,\"model\":\"PF20884\",\"representative\":false,\"integrated_identifier\":\"IPR035504\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/A0A494C071/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-A0A494C071-F1:v6", "n_domain_CA": 62, "core_mean_plddt": 79.9171 }, { "domain_id": "UP:Q9H0M4:PWWP1", "protein_id": "UP:Q9H0M4", "gene": "ZCWPW1", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 317, "end": 383, "length": 67, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PF00855\",\"PS50812\",\"SM00293\",\"cd20145\"]", "alternative_annotations": "[{\"source\":\"cdd\",\"identifier\":\"cd20145\",\"name\":\"PWWP domain found in zinc finger CW-type PWWP domain protein 1 (ZCWPW1) and similar proteins\",\"start\":310,\"end\":425,\"score\":4.19738e-56,\"model\":\"cd20145\",\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9H0M4/?page_size=200\"},{\"source\":\"smart\",\"identifier\":\"SM00293\",\"name\":\"domain with conserved PWWP motif\",\"start\":315,\"end\":381,\"score\":6.7e-07,\"model\":\"SM00293\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9H0M4/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":315,\"end\":412,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9H0M4/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":317,\"end\":383,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9H0M4/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":318,\"end\":412,\"score\":5e-13,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q9H0M4/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q9H0M4-F1:v6", "n_domain_CA": 67, "core_mean_plddt": 93.506 }, { "domain_id": "UP:Q504Y3:PWWP1", "protein_id": "UP:Q504Y3", "gene": "ZCWPW2", "taxonomy_id": "9606", "domain_name": "PWWP1", "start": 98, "end": 162, "length": 65, "source": "UniProtKB reviewed feature", "evidence": "[{\"evidenceCode\":\"ECO:0000255\",\"source\":\"PROSITE-ProRule\",\"id\":\"PRU00162\"}]", "identifiers": "[\"IPR000313\",\"PF00855\",\"PS50812\",\"cd20146\"]", "alternative_annotations": "[{\"source\":\"cdd\",\"identifier\":\"cd20146\",\"name\":\"PWWP domain found in zinc finger CW-type PWWP domain protein 2 (ZCWPW2) and similar proteins\",\"start\":88,\"end\":195,\"score\":4.24516e-48,\"model\":\"cd20146\",\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q504Y3/?page_size=200\"},{\"source\":\"profile\",\"identifier\":\"PS50812\",\"name\":\"PWWP domain profile\",\"start\":98,\"end\":151,\"score\":null,\"model\":\"PS50812\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q504Y3/?page_size=200\"},{\"source\":\"interpro\",\"identifier\":\"IPR000313\",\"name\":\"PWWP domain\",\"start\":98,\"end\":183,\"score\":null,\"model\":null,\"representative\":false,\"integrated_identifier\":null,\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q504Y3/?page_size=200\"},{\"source\":\"pfam\",\"identifier\":\"PF00855\",\"name\":\"PWWP domain\",\"start\":99,\"end\":183,\"score\":2.9e-07,\"model\":\"PF00855\",\"representative\":false,\"integrated_identifier\":\"IPR000313\",\"source_url\":\"https://www.ebi.ac.uk/interpro/api/entry/all/protein/uniprot/Q504Y3/?page_size=200\"}]", "membership_tier": "annotation_supported", "boundary_scope": "annotation core; not a certified complete folded domain or pocket", "associated_PDB_entries": 0, "observed_core_PDB_entries": 0, "max_CA_core_coverage": 0.0, "model_record_id": "AF-Q504Y3-F1:v6", "n_domain_CA": 65, "core_mean_plddt": 92.8174 } ], "interpretation": "Evidence gaps describe this curated snapshot; absence here is not proof of absence from the literature.", "current_source_checks": [ { "source_url": "https://www.rcsb.org/structure/9E3R", "checked_date": "2026-10-26", "finding": "Current RCSB title still explicitly reports PWWP deletion; frozen mapped ranges overlap the core. Construct interpretation remains a source conflict.", "status": "requires_construct_verification" }, { "source_url": "https://www.rcsb.org/structure/11OA", "checked_date": "2026-10-26", "finding": "Current RCSB metadata identifies a 5.04-Angstrom EM structure with the R882H mutation. Completeness was evaluated directly from the frozen mmCIF, not inferred from resolution.", "status": "metadata_checked" } ], "new_structure_search_scope": "Targeted current RCSB web searches for NSD2 PWWP 2026, NSD3 PWWP 2026 and NSD1 PWWP 2026; no unverified new record promoted. This is not a family-wide exhaustive update.", "search_queries": [ "site.rcsb.org/structure NSD2 PWWP 2026", "site.rcsb.org/structure NSD3 PWWP 2026", "site.rcsb.org/structure \"PWWP\" \"11OA\"", "site.rcsb.org/structure/9E3R PWWP deleted", "site.rcsb.org/structure \"NSD2\" \"UNC10415667\"", "site.rcsb.org/structure \"PWWP\" \"2026\" \"NSD1\"" ] }