Experimental coordinates · Exact deposited instances
Ligand contacts & pocket quality
Inspect the atoms that are present, the residues that are missing, and the precise scope of each chemical association.
Phase 6C historical atom / receptor assessment Phase 6C.1 full-atom experimental quality inventory
Full-coordinate Phase 6C.1 atom and ligand environment assessment
Load the checksum-verified original coordinates to explore the selected chain and ligand.
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Atom completeness · selected chain and annotation core
What can these coordinates support?
A fully observed annotation core is not a complete-receptor certification. Short annotation intervals, absent peripheral residues, alternate conformers and unexamined density can limit structural interpretation. No receptor preparation was performed.
Frozen 5 Å heavy-atom proximity observations
Contacting residues · A1J21
Heavy-atom distances use the first deposited model and asymmetric unit, occupancy >0 and retained alternate locations. No symmetry expansion or affinity inference. Proximity alone is not evidence of affinity or a functional interaction.
| Canonical residue | Deposited residue | Scope | Minimum distance | Atom quality | Inspect |
|---|---|---|---|---|---|
| VAL 230 | B:230 · entity 230 · label B | outside PWWP annotations | 4.8527 Å | Unassessed | |
| TYR 233 | B:233 · entity 233 · label B | outside PWWP annotations | 4.0164 Å | Unassessed | |
| LYS 251 | B:251 · entity 251 · label B | outside PWWP annotations | 3.2050 Å | Unassessed | |
| PHE 266 | B:266 · entity 266 · label B | outside PWWP annotations | 3.3228 Å | Unassessed | |
| PHE 267 | B:267 · entity 267 · label B | outside PWWP annotations | 4.0913 Å | Unassessed | |
| GLY 268 | B:268 · entity 268 · label B | outside PWWP annotations | 3.1610 Å | Unassessed | |
| ASP 269 | B:269 · entity 269 · label B | outside PWWP annotations | 2.2590 Å | Unassessed | |
| ALA 270 | B:270 · entity 270 · label B | outside PWWP annotations | 3.9707 Å | Unassessed | |
| GLU 272 | B:272 · entity 272 · label B | outside PWWP annotations | 2.9318 Å | Unassessed | |
| ARG 273 | B:273 · entity 273 · label B | outside PWWP annotations | 2.8456 Å | Unassessed | |
| ALA 274 | B:274 · entity 274 · label B | outside PWWP annotations | 3.6534 Å | Unassessed | |
| TRP 275 | B:275 · entity 275 · label B | outside PWWP annotations | 3.2811 Å | Unassessed | |
| GLN 321 | B:321 · entity 321 · label B | outside PWWP annotations | 3.7260 Å | Unassessed | |
| MET 324 | B:324 · entity 324 · label B | outside PWWP annotations | 3.0131 Å | Unassessed | |
| GLN 328 | B:328 · entity 328 · label B | outside PWWP annotations | 3.5302 Å | Unassessed |
Identity, native target and exact site links
Linked experimental assays
| Measured preparation | Method / endpoint | Original observation | Tested construct | Evidence |
|---|---|---|---|---|
| No exact site-to-assay link is established in the frozen evidence graph. Visit the domain's Ligands & Bioactivity section for newly curated or structure-free observations. | ||||
Filterable structural assessment inventory
Coordinate coverage & quality
| PDB / chain | Domain | Core Cα coverage | PWWP-contact ligand instances | Atom assessment | Missing core heavy atoms |
|---|---|---|---|---|---|
| 29HG · B | NSD2 PWWP2 | 0 / 63 | 0 | Unassessed | — |
| 29HH · B | NSD2 PWWP2 | 0 / 63 | 0 | Unassessed | — |
| 29HI · B | NSD2 PWWP2 | 0 / 63 | 0 | Unassessed | — |
| 7CRO · K | NSD2 PWWP2 | 0 / 63 | 0 | Unassessed | — |
Source bytes, methods and provenance
Detailed atom completeness only for the three packaged original-coordinate files; quality uses observed atom-name union across positive-occupancy alternate conformers, with per-alt differences retained. Missing entire residues are separate. Nonstandard amino-acid templates are unassessed. No density reinterpretation, receptor repair, docking or MD.
Coordinate SHA-256: c006a7e843b63ecfdfaf2bcda3c6f288df350def6fa1f60ed8201cbe9fbdeafd
Source PDB: https://www.rcsb.org/structure/29HI. Original coordinate file: mmCIF. Original annotation and contact calculations are retained unchanged; the additional completeness assessment is PWWP_POCKET_QUALITY_1.0.0.
Methods and reproducible builder are included under analysis/phase5_pockets and scripts/build_phase5_pockets.py in the downloadable release.