Experimental coordinates · Exact deposited instances
Ligand contacts & pocket quality
Inspect the atoms that are present, the residues that are missing, and the precise scope of each chemical association.
Phase 6C historical atom / receptor assessment Phase 6C.1 full-atom experimental quality inventory
Full-coordinate Phase 6C.1 atom and ligand environment assessment
Load the checksum-verified original coordinates to explore the selected chain and ligand.
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Atom completeness · selected chain and annotation core
What can these coordinates support?
A fully observed annotation core is not a complete-receptor certification. Short annotation intervals, absent peripheral residues, alternate conformers and unexamined density can limit structural interpretation. No receptor preparation was performed.
Frozen 5 Å heavy-atom proximity observations
Contacting residues · EPE
Heavy-atom distances use the first deposited model and asymmetric unit, occupancy >0 and retained alternate locations. No symmetry expansion or affinity inference. Proximity alone is not evidence of affinity or a functional interaction.
| Canonical residue | Deposited residue | Scope | Minimum distance | Atom quality | Inspect |
|---|---|---|---|---|---|
| TYR 281 | A:281 · entity 36 · label A | annotation core | 3.3584 Å | Unassessed | |
| TRP 284 | A:284 · entity 39 · label A | annotation core | 3.2804 Å | Unassessed | |
| PHE 312 | A:312 · entity 67 · label A | annotation core | 3.3789 Å | Unassessed | |
| PHE 313 | A:313 · entity 68 · label A | annotation core | 4.8323 Å | Unassessed | |
| SER 314 | A:314 · entity 69 · label A | annotation core | 3.3667 Å | Unassessed | |
| GLN 316 | A:316 · entity 71 · label A | annotation core | 3.8851 Å | Unassessed | |
| GLU 318 | A:318 · entity 73 · label A | annotation core | 2.9234 Å | Unassessed | |
| PRO 361 | A:361 · entity 116 · label A | broader Pfam PWWP | 4.4615 Å | Unassessed | |
| ARG 363 | A:363 · entity 118 · label A | broader Pfam PWWP | 3.3902 Å | Unassessed | |
| GLU 364 | A:364 · entity 119 · label A | broader Pfam PWWP | 3.8604 Å | Unassessed | |
| GLN 367 | A:367 · entity 122 · label A | broader Pfam PWWP | 3.7711 Å | Unassessed |
Identity, native target and exact site links
Linked experimental assays
| Measured preparation | Method / endpoint | Original observation | Tested construct | Evidence |
|---|---|---|---|---|
| No exact site-to-assay link is established in the frozen evidence graph. Visit the domain's Ligands & Bioactivity section for newly curated or structure-free observations. | ||||
Filterable structural assessment inventory
Coordinate coverage & quality
| PDB / chain | Domain | Core Cα coverage | PWWP-contact ligand instances | Atom assessment | Missing core heavy atoms |
|---|---|---|---|---|---|
| 6G24 · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G25 · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G27 · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G29 · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G2B · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G2C · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G2E · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G2F · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G2O · A | NSD3 PWWP1 | 64 / 64 | 1 | Assessed | 0 |
| 6G3P · A | NSD3 PWWP1 | 64 / 64 | 0 | Unassessed | — |
| 6G3P · B | NSD3 PWWP1 | 64 / 64 | 0 | Unassessed | — |
| 6G3P · C | NSD3 PWWP1 | 64 / 64 | 0 | Unassessed | — |
| 6G3P · D | NSD3 PWWP1 | 64 / 64 | 0 | Unassessed | — |
| 6G3T · A | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G3T · B | NSD3 PWWP1 | 64 / 64 | 2 | Unassessed | — |
| 6G3T · C | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
| 6G3T · D | NSD3 PWWP1 | 64 / 64 | 1 | Unassessed | — |
Source bytes, methods and provenance
Detailed atom completeness only for the three packaged original-coordinate files; quality uses observed atom-name union across positive-occupancy alternate conformers, with per-alt differences retained. Missing entire residues are separate. Nonstandard amino-acid templates are unassessed. No density reinterpretation, receptor repair, docking or MD.
Coordinate SHA-256: bcb9eefd74501eef94395c8084b387e431f9bd9bff20e41b2999992d42af23c5
Source PDB: https://www.rcsb.org/structure/6G3T. Original coordinate file: mmCIF. Original annotation and contact calculations are retained unchanged; the additional completeness assessment is PWWP_POCKET_QUALITY_1.0.0.
Methods and reproducible builder are included under analysis/phase5_pockets and scripts/build_phase5_pockets.py in the downloadable release.