Phase 6D · Source-based structural correspondence
Experimental domain comparison
Two original deposited PWWP structures and the source-qualified least-squares comparison. Alignment values are descriptive geometry; ligand potency or binding function is not inferred.
57Globally mapped Cα pairs
3.149 ÅGlobal aligned-core RMSD
23Local mapped Cα pairs
2.696 ÅLocal reference-region RMSD
DNMT3A · 3LLR
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NSD3 · 6G25
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Structural fit and evidence
- Comparison status
- Calculated
- Whole core
- qualified_frozen_MSA_Calpha
- Local region
- NSD2_ligand_site_homology_transferred_reference_patch
- Source reference
- Frozen qualified 39-instance evolutionary alignment and independently observed representative core coordinates
Downloadable precomputed rigid transformation (B into A)
Row-vector convention: coordinate B × R + t → coordinate A. These values correspond to the listed mapped Cα positions and exclude reflections.
Rotation: [[-0.4597465721608835, -0.3009936439459165, -0.8354854371504485], [0.7897049184087359, 0.2917643275767531, -0.5396663033715714], [0.40620097393700166, -0.907896692062398, 0.10355851155162049]]\nTranslation (Å): [-8.6688146388767, 38.49244002541255, 0.7802070078203762]\nAligned MSA columns: ["132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "24", "25", "26", "27", "28", "29", "30", "31", "32", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59"]