Original experimental coordinate assessment

6XCG · NSD2 PWWP1

Label protein chain C · author chain(s) C · canonical annotation core 222–286

assessed from original mmcifrequires structural reviewX-RAY DIFFRACTION

Original deposited structure Protein/domain evidence Original-coordinate 3D viewer Download record as JSON

63 / 65Core Cα observations

63Residues with coordinates

4Missing heavy side-chain atoms in observed residues

1Verified local PWWP research-ligand instances

Independent actual-atom audit

Core residue completeness

All residue records CSV

The annotation core is shown only at positions supported by the original protein/entity-to-UniProt mapping. Unobserved residues are separate from observed residues whose side chains lack deposited atoms. Partial occupancies and alternate conformations are recorded independently.

Canonical	Author residue	Component	Source presence	Observed heavy atoms	Missing backbone atoms	Missing side-chain atoms	Alternate/occupancy warnings
222	C:222	VAL	Observed	7		None
223	C:223	GLY	Observed	4		None
224	C:224	ASP	Observed	8		None
225	C:225	LEU	Observed	8		None
226	C:226	VAL	Observed	7		None
227	C:227	TRP	Observed	14		None
228	C:228	SER	Observed	6		None
229	C:229	LYS	Observed	9		None
230	C:230	VAL	Observed	7		None
231	C:231	SER	Observed	6		None
232	C:232	GLY	Observed	4		None
233	C:233	TYR	Observed	12		None
234	C:234	PRO	Observed	7		None
235	C:235	TRP	Observed	14		None
236	C:236	TRP	Observed	14		None
237	C:237	PRO	Observed	7		None
238	C:238	CYS	Observed	6		None
239	C:239	MET	Observed	8		None
240	C:240	VAL	Observed	7		None
241	C:241	SER	Observed	6		None
242	C:242	ALA	Observed	5		None
243	C:243	ASP	Observed	8		None
244	C:244	PRO	Observed	7		None
245	C:245	LEU	Observed	8		None
246	C:246	LEU	Observed	8		None
247	C:247	HIS	Observed	10		None
248	C:248	SER	Observed	6		None
249	C:249	TYR	Observed	12		None
250	C:250	THR	Observed	7		None
251	C:251	LYS	Observed	9		None
252	C:252	LEU	Observed	8		None
253	C:253	LYS	Observed	9		None
254	C:254	GLY	Observed	4		None
255	C:255	GLN	Observed	9		None
256	C:—	LYS	Unobserved entire residue	0	N/A	N/A
257	C:—	LYS	Unobserved entire residue	0	N/A	N/A
258	C:258	SER	Observed	6		None
259	C:259	ALA	Observed	5		None
260	C:260	ARG	Observed	11		None
261	C:261	GLN	Observed	9		None
262	C:262	TYR	Observed	12		None
263	C:263	HIS	Observed	10		None
264	C:264	VAL	Observed	7		None
265	C:265	GLN	Observed	9		None
266	C:266	PHE	Observed	11		None
267	C:267	PHE	Observed	11		None
268	C:268	GLY	Observed	4		None
269	C:269	ASP	Observed	8		None
270	C:270	ALA	Observed	5		None
271	C:271	PRO	Observed	7		None
272	C:272	GLU	Observed	9		None	Alternate A, B Partial occupancy: C, CA, CB, CD, CG, N, O, OE1, OE2
273	C:273	ARG	Observed	11		None
274	C:274	ALA	Observed	5		None
275	C:275	TRP	Observed	14		None
276	C:276	ILE	Observed	8		None
277	C:277	PHE	Observed	11		None
278	C:278	GLU	Observed	9		None
279	C:279	LYS	Observed	5		CD, CE, CG, NZ
280	C:280	SER	Observed	6		None
281	C:281	LEU	Observed	8		None
282	C:282	VAL	Observed	7		None
283	C:283	ALA	Observed	5		None
284	C:284	PHE	Observed	11		None
285	C:285	GLU	Observed	9		None
286	C:286	GLY	Observed	4		None

Exact deposited instances

Experimentally defined PWWP ligand environments

12 contacting core residues at ≤ 5 Å11 at ≤ 4 Å2.886 Å minimum0 missing side-chain atoms in observed contacting residues

Local flags: alternate conformations, partially occupied nearest atom

Actual atom-to-atom contact distances (first model; no symmetry expansion)

Canonical position	Author position	Protein atom	Ligand atom	Distance Å	Scope	Missing side-chain atoms
230	C:230	VAL CG2	V01 C2	3.7533	Native PWWP core	None
233	C:233	TYR OH	V01 O	3.326	Native PWWP core	None
236	C:236	TRP CE3	V01 C3	3.5912	Native PWWP core	None
266	C:266	PHE CB	V01 O2	3.1984	Native PWWP core	None
267	C:267	PHE O	V01 C19	3.2908	Native PWWP core	None
268	C:268	GLY C	V01 O3	3.1601	Native PWWP core	None
269	C:269	ASP N	V01 O3	3.206	Native PWWP core	None
270	C:270	ALA O	V01 C20	2.9688	Native PWWP core	None
271	C:271	PRO C	V01 O2	4.4163	Native PWWP core	None
272	C:272	GLU CG	V01 C14	3.4199	Native PWWP core	None
273	C:273	ARG O	V01 N1	2.886	Native PWWP core	None
274	C:274	ALA CB	V01 C8	3.7615	Native PWWP core	None
318	C:318	LEU CD2	V01 C22	3.3244	Mapped construct outside core	None
321	C:321	GLN OE1	V01 N4	2.794	Mapped construct outside core	None

Source and interpretation

PDB source: 6XCG; domain: UP:O96028:PWWP1.

Original coordinate SHA-256: 2c370701c9b83de7ae6137f91d2130519a48c261a93ec5bc480dfcc3bc982200. The program never creates modeled missing atoms, rescores affinities, or declares a docking-ready receptor. Official validation reports and experimental maps were not independently inspected.

Core residue completeness

Experimentally defined PWWP ligand environments

V01 · label ligand I

Source and interpretation