Phase 6C.1 · Original deposited experimental coordinates

Comprehensive structure quality

Residue and heavy-atom completeness calculated directly from 230 source PDBx/mmCIF files, each verified against its frozen historical checksum. Each mapped PWWP chain/domain, NMR model and qualified source-supported ligand environment is tracked individually.

230Historically verified coordinate files

496Chain/domains with an observed PWWP core

283Source-supported ligand environments calculated

170Mapped chain/domains lacking observed core coordinates

Experimental-coordinate case studies

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9FOC · NSD2 PWWP1

Newly assessed ligand-bearing structure

Protein and bound ligand coordinates are deposited, but the literature's assayed compound 11 preparation remains stereochemically unresolved. Structural components do not fix that ambiguity.

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2M16 · PSIP1 PWWP

Deposited NMR ensemble

All model-specific atom observations are retained. Ensemble variation is not represented by a single first-model structure alone.

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11OA · DNMT3A PWWP1

Independently confirmed side-chain gaps

Five observed-core chains each lack 198 standard side-chain heavy atoms; 13 other mapped chains contain no observed core coordinates.

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All 666 original chain/domain mappings

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666 matching chain/domain records. Filters must be satisfied by the same experimental chain/domain. Model-specific assessment is available within each detail record.

PDB · chain	Target/domain	Core observed	Experiment	Missing side-chain atoms	Backbone gaps	Research ligand environments	Assessment
6UE6 · D	NSD2 PWWP1	61 / 65	X-RAY DIFFRACTION · 2.4 Å	19	3	2	atomic completeness calculated
6UE6 · E	NSD2 PWWP1	63 / 65	X-RAY DIFFRACTION · 2.4 Å	29	2	2	atomic completeness calculated
6UE6 · F	NSD2 PWWP1	60 / 65	X-RAY DIFFRACTION · 2.4 Å	14	0	2	atomic completeness calculated
6UE6 · G	NSD2 PWWP1	62 / 65	X-RAY DIFFRACTION · 2.4 Å	12	0	2	atomic completeness calculated
6UE6 · H	NSD2 PWWP1	60 / 65	X-RAY DIFFRACTION · 2.4 Å	10	0	2	atomic completeness calculated
6XCG · A	NSD2 PWWP1	65 / 65	X-RAY DIFFRACTION · 1.64 Å	6	0	1	atomic completeness calculated
6XCG · B	NSD2 PWWP1	65 / 65	X-RAY DIFFRACTION · 1.64 Å	12	0	1	atomic completeness calculated
6XCG · C	NSD2 PWWP1	63 / 65	X-RAY DIFFRACTION · 1.64 Å	4	0	1	atomic completeness calculated
7CRO · K	NSD2 PWWP2	0 / 63	ELECTRON MICROSCOPY · 3.75 Å	Core not observed	0	0	domain not observed in deposit
7CRP · K	NSD3 PWWP2	0 / 63	ELECTRON MICROSCOPY · 3.2 Å	Core not observed	0	0	domain not observed in deposit
7CRQ · K	NSD3 PWWP2	0 / 63	ELECTRON MICROSCOPY · 3.15 Å	Core not observed	0	0	domain not observed in deposit
7CRQ · L	NSD3 PWWP2	0 / 63	ELECTRON MICROSCOPY · 3.15 Å	Core not observed	0	0	domain not observed in deposit
7CRR · K	NSD3 PWWP2	0 / 63	ELECTRON MICROSCOPY · 3.48 Å	Core not observed	0	0	domain not observed in deposit
7E29 · A	IOC4 PWWP1	101 / 151	X-RAY DIFFRACTION · 2.303 Å	0	0	0	atomic completeness calculated
7HG0 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.58 Å	2	0	1	atomic completeness calculated
7HG0 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.58 Å	9	0	1	atomic completeness calculated
7HG0 · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.58 Å	18	0	0	atomic completeness calculated
7HG1 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.81 Å	5	0	1	atomic completeness calculated
7HG1 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.81 Å	9	0	1	atomic completeness calculated
7HG1 · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.81 Å	18	0	0	atomic completeness calculated
7HG2 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.7 Å	5	0	2	atomic completeness calculated
7HG2 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.7 Å	9	0	1	atomic completeness calculated
7HG2 · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.7 Å	18	0	0	atomic completeness calculated
7HG3 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.45 Å	5	0	1	atomic completeness calculated
7HG3 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.45 Å	9	0	1	atomic completeness calculated
7HG3 · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.45 Å	18	0	0	atomic completeness calculated
7HG4 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.57 Å	2	0	1	atomic completeness calculated
7HG4 · B	HDGFL2 PWWP1	52 / 58	X-RAY DIFFRACTION · 1.57 Å	5	0	1	atomic completeness calculated
7HG4 · C	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.57 Å	18	0	0	atomic completeness calculated
7HG5 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.57 Å	5	0	1	atomic completeness calculated
7HG5 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.57 Å	9	0	1	atomic completeness calculated
7HG5 · C	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.57 Å	15	0	1	atomic completeness calculated
7HG6 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.52 Å	2	0	1	atomic completeness calculated
7HG6 · B	HDGFL2 PWWP1	52 / 58	X-RAY DIFFRACTION · 1.52 Å	5	0	1	atomic completeness calculated
7HG6 · C	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.52 Å	18	0	0	atomic completeness calculated
7HG7 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.76 Å	5	0	1	atomic completeness calculated
7HG7 · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.76 Å	6	0	1	atomic completeness calculated
7HG7 · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.76 Å	11	0	0	atomic completeness calculated
7HG8 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.67 Å	5	0	1	atomic completeness calculated
7HG8 · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.67 Å	9	0	1	atomic completeness calculated
7HG8 · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.67 Å	18	0	0	atomic completeness calculated
7HG9 · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.58 Å	0	0	1	atomic completeness calculated
7HG9 · B	HDGFL2 PWWP1	52 / 58	X-RAY DIFFRACTION · 1.58 Å	5	0	1	atomic completeness calculated
7HG9 · C	HDGFL2 PWWP1	52 / 58	X-RAY DIFFRACTION · 1.58 Å	15	0	1	atomic completeness calculated
7HGA · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.57 Å	5	0	1	atomic completeness calculated
7HGA · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.57 Å	6	0	1	atomic completeness calculated
7HGA · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.57 Å	12	0	0	atomic completeness calculated
7HGB · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.52 Å	2	0	1	atomic completeness calculated
7HGB · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.52 Å	9	0	1	atomic completeness calculated
7HGB · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.52 Å	18	0	0	atomic completeness calculated
7HGC · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.51 Å	2	0	1	atomic completeness calculated
7HGC · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.51 Å	6	0	1	atomic completeness calculated
7HGC · C	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.51 Å	12	0	0	atomic completeness calculated
7HGD · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.65 Å	0	0	2	atomic completeness calculated
7HGD · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.65 Å	6	0	1	atomic completeness calculated
7HGD · C	HDGFL2 PWWP1	50 / 58	X-RAY DIFFRACTION · 1.65 Å	8	0	0	atomic completeness calculated
7HGE · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.77 Å	5	0	1	atomic completeness calculated
7HGE · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.77 Å	6	0	1	atomic completeness calculated
7HGE · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.77 Å	18	0	0	atomic completeness calculated
7HGF · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.55 Å	2	0	1	atomic completeness calculated
7HGF · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.55 Å	9	0	1	atomic completeness calculated
7HGF · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.55 Å	18	0	0	atomic completeness calculated
7HGG · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.61 Å	5	0	1	atomic completeness calculated
7HGG · B	HDGFL2 PWWP1	52 / 58	X-RAY DIFFRACTION · 1.61 Å	5	0	1	atomic completeness calculated
7HGG · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.61 Å	11	0	0	atomic completeness calculated
7HGH · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.74 Å	3	0	1	atomic completeness calculated
7HGH · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.74 Å	7	0	1	atomic completeness calculated
7HGH · C	HDGFL2 PWWP1	50 / 58	X-RAY DIFFRACTION · 1.74 Å	8	0	0	atomic completeness calculated
7HGI · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.71 Å	2	0	1	atomic completeness calculated
7HGI · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.71 Å	9	0	1	atomic completeness calculated
7HGI · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.71 Å	11	0	1	atomic completeness calculated
7HGJ · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.75 Å	0	0	1	atomic completeness calculated
7HGJ · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.75 Å	9	0	1	atomic completeness calculated
7HGJ · C	HDGFL2 PWWP1	56 / 58	X-RAY DIFFRACTION · 1.75 Å	18	0	1	atomic completeness calculated
7HGK · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.59 Å	5	0	1	atomic completeness calculated
7HGK · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.59 Å	6	0	1	atomic completeness calculated
7HGK · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.59 Å	12	0	0	atomic completeness calculated
7HGL · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.73 Å	2	0	1	atomic completeness calculated
7HGL · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.73 Å	9	0	1	atomic completeness calculated
7HGL · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.73 Å	15	0	1	atomic completeness calculated
7HGM · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.61 Å	5	0	2	atomic completeness calculated
7HGM · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.61 Å	9	0	1	atomic completeness calculated
7HGM · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.61 Å	18	0	1	atomic completeness calculated
7HGN · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.55 Å	2	0	1	atomic completeness calculated
7HGN · B	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.55 Å	9	0	1	atomic completeness calculated
7HGN · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.55 Å	12	0	1	atomic completeness calculated
7HGO · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.44 Å	2	0	1	atomic completeness calculated
7HGO · B	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.44 Å	9	0	1	atomic completeness calculated
7HGO · C	HDGFL2 PWWP1	53 / 58	X-RAY DIFFRACTION · 1.44 Å	18	0	0	atomic completeness calculated
7HGP · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.62 Å	2	0	1	atomic completeness calculated
7HGP · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.62 Å	9	0	0	atomic completeness calculated
7HGP · C	HDGFL2 PWWP1	50 / 58	X-RAY DIFFRACTION · 1.62 Å	8	0	0	atomic completeness calculated
7HGQ · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.76 Å	2	0	1	atomic completeness calculated
7HGQ · B	HDGFL2 PWWP1	55 / 58	X-RAY DIFFRACTION · 1.76 Å	9	0	1	atomic completeness calculated
7HGQ · C	HDGFL2 PWWP1	51 / 58	X-RAY DIFFRACTION · 1.76 Å	10	0	0	atomic completeness calculated
7HGR · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.41 Å	3	0	1	atomic completeness calculated
7HGR · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.41 Å	7	0	1	atomic completeness calculated
7HGR · C	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.41 Å	15	0	1	atomic completeness calculated
7HGS · A	HDGFL2 PWWP1	58 / 58	X-RAY DIFFRACTION · 1.51 Å	5	0	1	atomic completeness calculated
7HGS · B	HDGFL2 PWWP1	54 / 58	X-RAY DIFFRACTION · 1.51 Å	7	0	1	atomic completeness calculated

Reproducible scientific exports

Individual experimental mmCIF files are verified by their original SHA-256. Core coordinates, standard heavy-atom templates and source UniProt mappings are analyzed model-by-model. Union-of-alternates and conformer-consistent completeness are distinct; 5 Å and 6 Å geometric proximity are not equivalent to a validated interaction.

NMR and model assessments Ligand environment evidence Contact residue distances Coordinate provenance Calculation manifest