STRUCTURAL BIOLOGY & CHEMICAL EVIDENCEDataset v1.2 · Phase 6D · Comparative experimental recognition environments

Measured experimental coordinates · Phase 6C.1

8Z6C · HDGFL2 PWWP1

Source chain A, canonical annotation-core residues 7–64. X-RAY DIFFRACTION · reported 1.93 Å. Original-coordinate SHA-256: a52b0ce0d915a4ec6357f5dce14e0dbbacdb5fa856c24981a9187cf4168156c2.

58Core residues with observed coordinates (58 annotated)
0Missing heavy side-chain atoms in observed core
1Experimental models evaluated
1Source-supported ligand environments

Open deposited-coordinate molecular viewer Protein/domain context Original PDB entry

Model-aware structural assessment

Counts concern the annotated PWWP core. Different NMR models are evaluated independently, without averaging their coordinates into an artificial model.

ModelCore residues observedMissing backboneMissing side-chain (union)Missing side-chain (consistent conformer)Partial occupancy residuesUnassessable chemistry
15800000

Experimental ligand environments

Only separately source-classified research ligands are listed. Native annotation-core contacts and broader Pfam-fold contacts are identified separately. A simple distance is not an experimental affinity or density-quality score.

A1D73 · calculated observed ligand environment

Deposited instance PDB:8Z6C:LIG:D:A1D73:101:.. Closest calculated PWWP-region atom distance: 2.488 Å. Five-Å native core contacts: 9; broader-Pfam contacts: 0; source-coordinate model 1.

Limitations: partial occupancy contact atoms; multi chain environment source annotation

Canonical residueRegionProtein atomLigand atomDistance (Å)Occupancy
13 ALAnative annotation coreOBR125.0911.0 / 0.59
14 LYSnative annotation coreCBR125.84281.0 / 0.59
15 METnative annotation coreCEN033.23051.0 / 0.59
18 TYRnative annotation coreCE2C053.47571.0 / 0.59
19 PROnative annotation coreOBR125.07251.0 / 0.59
21 TRPnative annotation coreCE2C093.32311.0 / 0.59
44 PHEnative annotation coreCBN103.36861.0 / 0.59
45 PHEnative annotation coreON104.97511.0 / 0.59
47 THRnative annotation coreOG1N102.4881.0 / 0.59
48 HISnative annotation coreNN105.34621.0 / 0.59
49 GLUnative annotation coreOE1N113.3061.0 / 0.59
50 THRnative annotation coreOC024.37981.0 / 0.59
51 ALAnative annotation coreCBC023.90371.0 / 0.59

Residue-level coordinate and atom completeness

"Missing" applies only to residues with observed atoms and supported chemical templates. Unobserved residues are reported separately. Alternate-conformer union presence is distinct from a single internally consistent conformer.

Canonical / entity positionComponentObservedMissing backboneMissing side-chain (union)Missing side-chain (consistent)Alt & occupancy
7 / 7PROYes————; occupancy ≥ 1.0
8 / 8GLYYes————; occupancy ≥ 1.0
9 / 9ASPYes————; occupancy ≥ 1.0
10 / 10LEUYes————; occupancy ≥ 1.0
11 / 11VALYes————; occupancy ≥ 1.0
12 / 12PHEYes————; occupancy ≥ 1.0
13 / 13ALAYes————; occupancy ≥ 1.0
14 / 14LYSYes————; occupancy ≥ 1.0
15 / 15METYes————; occupancy ≥ 1.0
16 / 16LYSYes————; occupancy ≥ 1.0
17 / 17GLYYes————; occupancy ≥ 1.0
18 / 18TYRYes————; occupancy ≥ 1.0
19 / 19PROYes————; occupancy ≥ 1.0
20 / 20HISYes————; occupancy ≥ 1.0
21 / 21TRPYes————; occupancy ≥ 1.0
22 / 22PROYes————; occupancy ≥ 1.0
23 / 23ALAYes————; occupancy ≥ 1.0
24 / 24ARGYes————; occupancy ≥ 1.0
25 / 25ILEYes————; occupancy ≥ 1.0
26 / 26ASPYes————; occupancy ≥ 1.0
27 / 27ASPYes————; occupancy ≥ 1.0
28 / 28ILEYes————; occupancy ≥ 1.0
29 / 29ALAYes————; occupancy ≥ 1.0
30 / 30ASPYes————; occupancy ≥ 1.0
31 / 31GLYYes————; occupancy ≥ 1.0
32 / 32ALAYes————; occupancy ≥ 1.0
33 / 33VALYes————; occupancy ≥ 1.0
34 / 34LYSYes————; occupancy ≥ 1.0
35 / 35PROYes————; occupancy ≥ 1.0
36 / 36PROYes————; occupancy ≥ 1.0
37 / 37PROYes————; occupancy ≥ 1.0
38 / 38ASNYes————; occupancy ≥ 1.0
39 / 39LYSYes————; occupancy ≥ 1.0
40 / 40TYRYes————; occupancy ≥ 1.0
41 / 41PROYes————; occupancy ≥ 1.0
42 / 42ILEYes————; occupancy ≥ 1.0
43 / 43PHEYes————; occupancy ≥ 1.0
44 / 44PHEYes————; occupancy ≥ 1.0
45 / 45PHEYes————; occupancy ≥ 1.0
46 / 46GLYYes————; occupancy ≥ 1.0
47 / 47THRYes————; occupancy ≥ 1.0
48 / 48HISYes————; occupancy ≥ 1.0
49 / 49GLUYes————; occupancy ≥ 1.0
50 / 50THRYes————; occupancy ≥ 1.0
51 / 51ALAYes————; occupancy ≥ 1.0
52 / 52PHEYes————; occupancy ≥ 1.0
53 / 53LEUYes————; occupancy ≥ 1.0
54 / 54GLYYes————; occupancy ≥ 1.0
55 / 55PROYes————; occupancy ≥ 1.0
56 / 56LYSYes————; occupancy ≥ 1.0
57 / 57ASPYes————; occupancy ≥ 1.0
58 / 58LEUYes————; occupancy ≥ 1.0
59 / 59PHEYes————; occupancy ≥ 1.0
60 / 60PROYes————; occupancy ≥ 1.0
61 / 61TYRYes————; occupancy ≥ 1.0
62 / 62ASPYes————; occupancy ≥ 1.0
63 / 63LYSYes————; occupancy ≥ 1.0
64 / 64CYSYes————; occupancy ≥ 1.0

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