Measured experimental coordinates · Phase 6C.1
6UE6 · NSD2 PWWP1
Source chain E, canonical annotation-core residues 222–286. X-RAY DIFFRACTION · reported 2.4 Å. Original-coordinate SHA-256: fbf22f430937d8ed0ad110294f251af23fd33f7e8bf3164fe0dc9e3cb4f21d27.
Open deposited-coordinate molecular viewer Protein/domain context Original PDB entry
Model-aware structural assessment
Counts concern the annotated PWWP core. Different NMR models are evaluated independently, without averaging their coordinates into an artificial model.
| Model | Core residues observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent conformer) | Partial occupancy residues | Unassessable chemistry |
|---|---|---|---|---|---|---|
| 1 | 63 | 2 | 29 | 29 | 0 | 0 |
Experimental ligand environments
Only separately source-classified research ligands are listed. Native annotation-core contacts and broader Pfam-fold contacts are identified separately. A simple distance is not an experimental affinity or density-quality score.
Q5D · calculated observed ligand environment
Deposited instance PDB:6UE6:LIG:LB:Q5D:2001:.. Closest calculated PWWP-region atom distance: 3.5141 Å. Five-Å native core contacts: 1; broader-Pfam contacts: 4; source-coordinate model 1.
Limitations: multi chain environment source annotation
| Canonical residue | Region | Protein atom | Ligand atom | Distance (Å) | Occupancy |
|---|---|---|---|---|---|
| 269 ASP | native annotation core | OD2 | C15 | 3.8076 | 1.0 / 1.0 |
| 316 GLY | broader pfam outside annotation core | O | C13 | 4.9647 | 1.0 / 1.0 |
| 317 LYS | broader pfam outside annotation core | CD | O | 3.5858 | 1.0 / 1.0 |
| 320 ALA | broader pfam outside annotation core | CB | C14 | 3.5141 | 1.0 / 1.0 |
| 321 GLN | broader pfam outside annotation core | CG | C15 | 4.2323 | 1.0 / 1.0 |
Q5D · calculated observed ligand environment
Deposited instance PDB:6UE6:LIG:OA:Q5D:2001:.. Closest calculated PWWP-region atom distance: 3.0334 Å. Five-Å native core contacts: 12; broader-Pfam contacts: 1; source-coordinate model 1.
Limitations: multi chain environment source annotation
| Canonical residue | Region | Protein atom | Ligand atom | Distance (Å) | Occupancy |
|---|---|---|---|---|---|
| 228 SER | native annotation core | O | C10 | 5.5967 | 1.0 / 1.0 |
| 230 VAL | native annotation core | CG2 | C10 | 3.853 | 1.0 / 1.0 |
| 233 TYR | native annotation core | OH | O | 3.2909 | 1.0 / 1.0 |
| 234 PRO | native annotation core | O | C10 | 5.1787 | 1.0 / 1.0 |
| 236 TRP | native annotation core | CD2 | C9 | 3.4961 | 1.0 / 1.0 |
| 266 PHE | native annotation core | CE1 | C10 | 3.6318 | 1.0 / 1.0 |
| 267 PHE | native annotation core | O | N | 3.8951 | 1.0 / 1.0 |
| 268 GLY | native annotation core | CA | N | 3.3535 | 1.0 / 1.0 |
| 269 ASP | native annotation core | N | N | 3.4682 | 1.0 / 1.0 |
| 270 ALA | native annotation core | O | C5 | 3.0334 | 1.0 / 1.0 |
| 271 PRO | native annotation core | N | N | 4.3552 | 1.0 / 1.0 |
| 272 GLU | native annotation core | CG | C2 | 3.3482 | 1.0 / 1.0 |
| 273 ARG | native annotation core | O | C15 | 3.6266 | 1.0 / 1.0 |
| 274 ALA | native annotation core | CB | C14 | 3.902 | 1.0 / 1.0 |
| 276 ILE | native annotation core | CD1 | C13 | 5.9547 | 1.0 / 1.0 |
| 321 GLN | broader pfam outside annotation core | OE1 | C6 | 3.536 | 1.0 / 1.0 |
Residue-level coordinate and atom completeness
"Missing" applies only to residues with observed atoms and supported chemical templates. Unobserved residues are reported separately. Alternate-conformer union presence is distinct from a single internally consistent conformer.
| Canonical / entity position | Component | Observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent) | Alt & occupancy |
|---|---|---|---|---|---|---|
| 222 / 13 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 223 / 14 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 224 / 15 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 225 / 16 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 226 / 17 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 227 / 18 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 228 / 19 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 229 / 20 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 230 / 21 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 231 / 22 | SER | Yes | — | OG | OG | —; occupancy ≥ 1.0 |
| 232 / 23 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 233 / 24 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 234 / 25 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 235 / 26 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 236 / 27 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 237 / 28 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 238 / 29 | CYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 239 / 30 | MET | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 240 / 31 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 241 / 32 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 242 / 33 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 243 / 34 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 244 / 35 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 245 / 36 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 246 / 37 | LEU | Yes | — | CD1, CD2, CG | CD1, CD2, CG | —; occupancy ≥ 1.0 |
| 247 / 38 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 248 / 39 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 249 / 40 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 250 / 41 | THR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 251 / 42 | LYS | Yes | — | CE, NZ | CE, NZ | —; occupancy ≥ 1.0 |
| 252 / 43 | LEU | Yes | — | CD1 | CD1 | —; occupancy ≥ 1.0 |
| 253 / 44 | LYS | Yes | — | CE, NZ | CE, NZ | —; occupancy ≥ 1.0 |
| 254 / 45 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 255 / 46 | GLN | Yes | C, O | CB, CD, CG, NE2, OE1 | CB, CD, CG, NE2, OE1 | —; occupancy ≥ 1.0 |
| 256 / 47 | LYS | No coordinates | — | — | — | — |
| 257 / 48 | LYS | No coordinates | — | — | — | — |
| 258 / 49 | SER | Yes | — | OG | OG | —; occupancy ≥ 1.0 |
| 259 / 50 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 260 / 51 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 261 / 52 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 262 / 53 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 263 / 54 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 264 / 55 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 265 / 56 | GLN | Yes | — | NE2, OE1 | NE2, OE1 | —; occupancy ≥ 1.0 |
| 266 / 57 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 267 / 58 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 268 / 59 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 269 / 60 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 270 / 61 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 271 / 62 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 272 / 63 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 273 / 64 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 274 / 65 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 275 / 66 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 276 / 67 | ILE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 277 / 68 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 278 / 69 | GLU | Yes | — | CD, CG, OE1, OE2 | CD, CG, OE1, OE2 | —; occupancy ≥ 1.0 |
| 279 / 70 | LYS | Yes | — | CD, CE, CG, NZ | CD, CE, CG, NZ | —; occupancy ≥ 1.0 |
| 280 / 71 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 281 / 72 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 282 / 73 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 283 / 74 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 284 / 75 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 285 / 76 | GLU | Yes | — | CD, CG, OE1, OE2 | CD, CG, OE1, OE2 | —; occupancy ≥ 1.0 |
| 286 / 77 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
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