Measured experimental coordinates · Phase 6C.1
6G24 · NSD3 PWWP1
Source chain A, canonical annotation-core residues 270–333. X-RAY DIFFRACTION · reported 2.1 Å. Original-coordinate SHA-256: 62eba139ed2e869ab368ee8e6432d8bae192e1c8ba651b01c3cde95d75cd5d7a.
Open deposited-coordinate molecular viewer Protein/domain context Original PDB entry
Model-aware structural assessment
Counts concern the annotated PWWP core. Different NMR models are evaluated independently, without averaging their coordinates into an artificial model.
| Model | Core residues observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent conformer) | Partial occupancy residues | Unassessable chemistry |
|---|---|---|---|---|---|---|
| 1 | 64 | 0 | 0 | 0 | 0 | 0 |
Experimental ligand environments
Only separately source-classified research ligands are listed. Native annotation-core contacts and broader Pfam-fold contacts are identified separately. A simple distance is not an experimental affinity or density-quality score.
EH2 · calculated observed ligand environment
Deposited instance PDB:6G24:LIG:B:EH2:401:.. Closest calculated PWWP-region atom distance: 3.3228 Å. Five-Å native core contacts: 5; broader-Pfam contacts: 4; source-coordinate model 1.
| Canonical residue | Region | Protein atom | Ligand atom | Distance (Å) | Occupancy |
|---|---|---|---|---|---|
| 284 TRP | native annotation core | NE1 | C16 | 5.986 | 1.0 / 1.0 |
| 311 GLN | native annotation core | NE2 | C11 | 4.194 | 1.0 / 1.0 |
| 312 PHE | native annotation core | O | C9 | 4.4744 | 1.0 / 1.0 |
| 313 PHE | native annotation core | C | C14 | 3.6039 | 1.0 / 1.0 |
| 314 SER | native annotation core | C | C16 | 3.4863 | 1.0 / 1.0 |
| 315 ASN | native annotation core | N | C15 | 3.4759 | 1.0 / 1.0 |
| 316 GLN | native annotation core | N | C13 | 5.9256 | 1.0 / 1.0 |
| 367 GLN | broader pfam outside annotation core | OE1 | C15 | 3.3228 | 1.0 / 1.0 |
| 370 ILE | broader pfam outside annotation core | CG2 | C15 | 3.6863 | 1.0 / 1.0 |
| 371 GLY | broader pfam outside annotation core | N | C16 | 3.5838 | 1.0 / 1.0 |
| 374 HIS | broader pfam outside annotation core | NE2 | C2 | 3.3293 | 1.0 / 1.0 |
Residue-level coordinate and atom completeness
"Missing" applies only to residues with observed atoms and supported chemical templates. Unobserved residues are reported separately. Alternate-conformer union presence is distinct from a single internally consistent conformer.
| Canonical / entity position | Component | Observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent) | Alt & occupancy |
|---|---|---|---|---|---|---|
| 270 / 8 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 271 / 9 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 272 / 10 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 273 / 11 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 274 / 12 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 275 / 13 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 276 / 14 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 277 / 15 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 278 / 16 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 279 / 17 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 280 / 18 | THR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 281 / 19 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 282 / 20 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 283 / 21 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 284 / 22 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 285 / 23 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 286 / 24 | CYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 287 / 25 | MET | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 288 / 26 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 289 / 27 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 290 / 28 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 291 / 29 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 292 / 30 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 293 / 31 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 294 / 32 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 295 / 33 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 296 / 34 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 297 / 35 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 298 / 36 | THR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 299 / 37 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 300 / 38 | ILE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 301 / 39 | ASN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 302 / 40 | THR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 303 / 41 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 304 / 42 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 305 / 43 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 306 / 44 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 307 / 45 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 308 / 46 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 309 / 47 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 310 / 48 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 311 / 49 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 312 / 50 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 313 / 51 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 314 / 52 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 315 / 53 | ASN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 316 / 54 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 317 / 55 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 318 / 56 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 319 / 57 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 320 / 58 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 321 / 59 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 322 / 60 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 323 / 61 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 324 / 62 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 325 / 63 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 326 / 64 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 327 / 65 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 328 / 66 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 329 / 67 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 330 / 68 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 331 / 69 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 332 / 70 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 333 / 71 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
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