Measured experimental coordinates · Phase 6C.1
29HI · NSD2 PWWP1
Source chain B, canonical annotation-core residues 222–286. ELECTRON MICROSCOPY · reported 5.9 Å. Original-coordinate SHA-256: c006a7e843b63ecfdfaf2bcda3c6f288df350def6fa1f60ed8201cbe9fbdeafd.
Open deposited-coordinate molecular viewer Protein/domain context Original PDB entry
Model-aware structural assessment
Counts concern the annotated PWWP core. Different NMR models are evaluated independently, without averaging their coordinates into an artificial model.
| Model | Core residues observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent conformer) | Partial occupancy residues | Unassessable chemistry |
|---|---|---|---|---|---|---|
| 1 | 65 | 0 | 19 | 19 | 0 | 0 |
Experimental ligand environments
Only separately source-classified research ligands are listed. Native annotation-core contacts and broader Pfam-fold contacts are identified separately. A simple distance is not an experimental affinity or density-quality score.
A1J21 · calculated observed ligand environment
Deposited instance PDB:29HI:LIG:F:A1J21:501:.. Closest calculated PWWP-region atom distance: 2.259 Å. Five-Å native core contacts: 12; broader-Pfam contacts: 3; source-coordinate model 1.
| Canonical residue | Region | Protein atom | Ligand atom | Distance (Å) | Occupancy |
|---|---|---|---|---|---|
| 230 VAL | native annotation core | CG2 | C44 | 4.8527 | 1.0 / 1.0 |
| 233 TYR | native annotation core | CD2 | C44 | 4.0164 | 1.0 / 1.0 |
| 243 ASP | native annotation core | OD1 | C16 | 5.3101 | 1.0 / 1.0 |
| 251 LYS | native annotation core | NZ | O14 | 3.205 | 1.0 / 1.0 |
| 263 HIS | native annotation core | CD2 | C17 | 5.5023 | 1.0 / 1.0 |
| 266 PHE | native annotation core | CE2 | C43 | 3.3228 | 1.0 / 1.0 |
| 267 PHE | native annotation core | O | O40 | 4.0913 | 1.0 / 1.0 |
| 268 GLY | native annotation core | CA | C39 | 3.161 | 1.0 / 1.0 |
| 269 ASP | native annotation core | CG | O38 | 2.259 | 1.0 / 1.0 |
| 270 ALA | native annotation core | N | O38 | 3.9707 | 1.0 / 1.0 |
| 272 GLU | native annotation core | OE2 | C32 | 2.9318 | 1.0 / 1.0 |
| 273 ARG | native annotation core | O | N21 | 2.8456 | 1.0 / 1.0 |
| 274 ALA | native annotation core | CB | C47 | 3.6534 | 1.0 / 1.0 |
| 275 TRP | native annotation core | CD1 | C17 | 3.2811 | 1.0 / 1.0 |
| 321 GLN | broader pfam outside annotation core | NE2 | C41 | 3.726 | 1.0 / 1.0 |
| 324 MET | broader pfam outside annotation core | CE | O38 | 3.0131 | 1.0 / 1.0 |
| 328 GLN | broader pfam outside annotation core | OE1 | O38 | 3.5302 | 1.0 / 1.0 |
Residue-level coordinate and atom completeness
"Missing" applies only to residues with observed atoms and supported chemical templates. Unobserved residues are reported separately. Alternate-conformer union presence is distinct from a single internally consistent conformer.
| Canonical / entity position | Component | Observed | Missing backbone | Missing side-chain (union) | Missing side-chain (consistent) | Alt & occupancy |
|---|---|---|---|---|---|---|
| 222 / 222 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 223 / 223 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 224 / 224 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 225 / 225 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 226 / 226 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 227 / 227 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 228 / 228 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 229 / 229 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 230 / 230 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 231 / 231 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 232 / 232 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 233 / 233 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 234 / 234 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 235 / 235 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 236 / 236 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 237 / 237 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 238 / 238 | CYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 239 / 239 | MET | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 240 / 240 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 241 / 241 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 242 / 242 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 243 / 243 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 244 / 244 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 245 / 245 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 246 / 246 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 247 / 247 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 248 / 248 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 249 / 249 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 250 / 250 | THR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 251 / 251 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 252 / 252 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 253 / 253 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 254 / 254 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 255 / 255 | GLN | Yes | — | CD, CG, NE2, OE1 | CD, CG, NE2, OE1 | —; occupancy ≥ 1.0 |
| 256 / 256 | LYS | Yes | — | CB, CD, CE, CG, NZ | CB, CD, CE, CG, NZ | —; occupancy ≥ 1.0 |
| 257 / 257 | LYS | Yes | — | CD, CE, CG, NZ | CD, CE, CG, NZ | —; occupancy ≥ 1.0 |
| 258 / 258 | SER | Yes | — | CB, OG | CB, OG | —; occupancy ≥ 1.0 |
| 259 / 259 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 260 / 260 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 261 / 261 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 262 / 262 | TYR | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 263 / 263 | HIS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 264 / 264 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 265 / 265 | GLN | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 266 / 266 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 267 / 267 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 268 / 268 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 269 / 269 | ASP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 270 / 270 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 271 / 271 | PRO | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 272 / 272 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 273 / 273 | ARG | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 274 / 274 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 275 / 275 | TRP | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 276 / 276 | ILE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 277 / 277 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 278 / 278 | GLU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 279 / 279 | LYS | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 280 / 280 | SER | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 281 / 281 | LEU | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 282 / 282 | VAL | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 283 / 283 | ALA | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 284 / 284 | PHE | Yes | — | — | — | —; occupancy ≥ 1.0 |
| 285 / 285 | GLU | Yes | — | CD, CG, OE1, OE2 | CD, CG, OE1, OE2 | —; occupancy ≥ 1.0 |
| 286 / 286 | GLY | Yes | — | — | — | —; occupancy ≥ 1.0 |
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