Phase 6D · Source-based structural correspondence
Experimental domain comparison
Two original deposited PWWP structures and the source-qualified least-squares comparison. Alignment values are descriptive geometry; ligand potency or binding function is not inferred.
57Globally mapped Cα pairs
3.362 ÅGlobal aligned-core RMSD
23Local mapped Cα pairs
2.748 ÅLocal reference-region RMSD
BRD1 · 4Z02
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NSD3 · 6G25
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Structural fit and evidence
- Comparison status
- Calculated
- Whole core
- qualified_frozen_MSA_Calpha
- Local region
- NSD2_ligand_site_homology_transferred_reference_patch
- Source reference
- Frozen qualified 39-instance evolutionary alignment and independently observed representative core coordinates
Downloadable precomputed rigid transformation (B into A)
Row-vector convention: coordinate B × R + t → coordinate A. These values correspond to the listed mapped Cα positions and exclude reflections.
Rotation: [[0.7976218814534639, -0.4132541909601948, -0.43934076510206743], [-0.00481103701087295, 0.7240188166542796, -0.6897634428218242], [0.6031386143744366, 0.5522840997026534, 0.5755050695398887]]\nTranslation (Å): [57.62388709156903, 41.52524870730413, 16.194193626579043]\nAligned MSA columns: ["132", "133", "134", "135", "136", "137", "138", "139", "140", "141", "142", "143", "144", "145", "146", "152", "153", "154", "155", "156", "157", "158", "159", "160", "161", "162", "163", "164", "165", "166", "167", "24", "25", "26", "27", "28", "29", "30", "31", "32", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59"]