{
  "comparators": [
    {
      "domain_id": "UP:Q9VAA9:PWWP1",
      "gene": "Jasper",
      "organism": "Drosophila melanogaster",
      "uniprot": "Q9VAA9",
      "review_status": "UniProtKB unreviewed (TrEMBL)",
      "source_construct": "6KCO",
      "analysis_start": 8,
      "analysis_end": 91,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 0.935897
    },
    {
      "domain_id": "UP:O88509:PWWP1",
      "gene": "Dnmt3b",
      "organism": "Mus musculus",
      "uniprot": "O88509",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "1KHC",
      "analysis_start": 219,
      "analysis_end": 362,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 1.0
    },
    {
      "domain_id": "UP:Q9JMG7:PWWP1",
      "gene": "Hdgfl3",
      "organism": "Mus musculus",
      "uniprot": "Q9JMG7",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "1N27",
      "analysis_start": 8,
      "analysis_end": 90,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 0.948718
    },
    {
      "domain_id": "UP:Q8R5C8:PWWP1",
      "gene": "Zmynd11",
      "organism": "Mus musculus",
      "uniprot": "Q8R5C8",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "4N4G",
      "analysis_start": 275,
      "analysis_end": 371,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 0.923077
    },
    {
      "domain_id": "UP:Q8VHK7:PWWP1",
      "gene": "Hdgf",
      "organism": "Rattus norvegicus",
      "uniprot": "Q8VHK7",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "5XSK",
      "analysis_start": 1,
      "analysis_end": 100,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 0.987179
    },
    {
      "domain_id": "UP:Q586Y0:PWWP1",
      "gene": "28H13_90",
      "organism": "Trypanosoma brucei brucei (strain 927/4 GUTat10.1)",
      "uniprot": "Q586Y0",
      "review_status": "UniProtKB unreviewed (TrEMBL)",
      "source_construct": "2NAS",
      "analysis_start": 1,
      "analysis_end": 110,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 0.871795
    },
    {
      "domain_id": "UP:O59676:PWWP1",
      "gene": "pdp1",
      "organism": "Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
      "uniprot": "O59676",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "2L89",
      "analysis_start": 45,
      "analysis_end": 152,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 1.0
    },
    {
      "domain_id": "UP:O94312:PWWP1",
      "gene": "pdp2",
      "organism": "Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
      "uniprot": "O94312",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "1H3Z",
      "analysis_start": 118,
      "analysis_end": 225,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 1.0
    },
    {
      "domain_id": "UP:Q04213:PWWP1",
      "gene": "IOC4",
      "organism": "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
      "uniprot": "Q04213",
      "review_status": "UniProtKB reviewed (Swiss-Prot)",
      "source_construct": "7E29",
      "analysis_start": 1,
      "analysis_end": 178,
      "decision": "retain_as_structure_supported_comparator",
      "suitability": "Exact canonical sequence mapping to a deposited PWWP domain construct, except Zmynd11 subdomain within its mapped cassette.",
      "limitation": "Selected for experimental structural availability; not a justified outgroup, representative taxonomic survey, or one-to-one orthology assignment.",
      "retained_alignment_coverage": 1.0
    }
  ],
  "additional_taxa_added": 0,
  "decision": "No broad origin, duplication chronology, ancestral state or species-tree claim is made. Adding isolated taxa cannot repair short divergent alignment; balanced per-subfamily sampling is a prerequisite for those questions."
}