{
  "database_sha256": "0c53107a39e222b48611302b21fda5fb4ed50b190b6b39d41423ccc5ca5958f6",
  "scope": "Read-only fixed-release examples; no pooled potency or selectivity ranking",
  "evidence_denominators": {
    "all_assay_association_records": 46,
    "structural_projection_rows": 2027,
    "assay_linked_projection_rows": 103,
    "distinct_assays_with_exact_contact_link": 17,
    "assays_without_exact_contact_link": 29
  },
  "compound_11_preparation": [
    {
      "preparation_id": "PREP:COLLIE2025_11",
      "name": "compound 11 (Collie 2025)",
      "chemical_id": null,
      "identity_status": "assayed_stereoisomeric_mixture_not_single_chemical_identity",
      "modeled_candidate_ccd_ids": "[\"A1IEG\", \"A1IFS\"]",
      "identity_note": "Assayed diastereomeric preparation: pyrrolidine 2S fixed and sulfolane center racemic in the SI name. A1IEG/A1IFS are modeled candidates in 9FOC; mixture affinity is not assigned to either pure stereoisomer. Composition ratio and fraction-to-CCD assignment remain unresolved."
    }
  ],
  "compound_11_observations": [
    {
      "assay_record_id": "PWWP:ASSAY:0018",
      "gene": "NSD2",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_type": "SPR Kd",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "value_operator": "=",
      "value_uM": 1.02,
      "qualitative_result": null,
      "chemical_id": null,
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233",
      "assay_value_transferred_to_modeled_stereoisomers": 0
    },
    {
      "assay_record_id": "PWWP:ASSAY:0025",
      "gene": "NSD2",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_type": "SPR Kd",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "value_operator": "=",
      "value_uM": 2.3,
      "qualitative_result": null,
      "chemical_id": null,
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233",
      "assay_value_transferred_to_modeled_stereoisomers": 0
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0005",
      "gene": "NSD3",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_type": "SPR Kd counter-screen",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "value_operator": null,
      "value_uM": null,
      "qualitative_result": "No binding",
      "chemical_id": null,
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233",
      "assay_value_transferred_to_modeled_stereoisomers": 0
    }
  ],
  "compound_11_exact_contact_affinity_links": 0,
  "NSD3_counter_screens": [
    {
      "assay_record_id": "PWWP11:ASSAY:0001",
      "compound_name": "UNC6934",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": ">",
      "value_uM": 30.0,
      "qualitative_result": null,
      "preparation_id": "PREP:UNC6934",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0005",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": null,
      "value_uM": null,
      "qualitative_result": "No binding",
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0006",
      "compound_name": "compound 12 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": null,
      "value_uM": null,
      "qualitative_result": "No binding",
      "preparation_id": "PREP:COLLIE2025_12",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0007",
      "compound_name": "compound 13 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": null,
      "value_uM": null,
      "qualitative_result": "No binding",
      "preparation_id": "PREP:COLLIE2025_13",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0002",
      "compound_name": "compound 5 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": ">",
      "value_uM": 30.0,
      "qualitative_result": null,
      "preparation_id": "PREP:COLLIE2025_5",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0003",
      "compound_name": "compound 6 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": ">",
      "value_uM": 30.0,
      "qualitative_result": null,
      "preparation_id": "PREP:COLLIE2025_6",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP11:ASSAY:0004",
      "compound_name": "compound 7 (Collie 2025)",
      "assay_construct_start": 263,
      "assay_construct_end": 398,
      "assay_type": "SPR Kd counter-screen",
      "value_operator": ">",
      "value_uM": 30.0,
      "qualitative_result": null,
      "preparation_id": "PREP:COLLIE2025_7",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    }
  ],
  "NSD2_paired_construct_measurements": [
    {
      "assay_record_id": "PWWP:ASSAY:0014",
      "compound_name": "UNC6934",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.24,
      "preparation_id": "PREP:UNC6934",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0021",
      "compound_name": "UNC6934",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 1.33,
      "preparation_id": "PREP:UNC6934",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0018",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 1.02,
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0025",
      "compound_name": "compound 11 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 2.3,
      "preparation_id": "PREP:COLLIE2025_11",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0019",
      "compound_name": "compound 12 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 1.47,
      "preparation_id": "PREP:COLLIE2025_12",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0026",
      "compound_name": "compound 12 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 2.8,
      "preparation_id": "PREP:COLLIE2025_12",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0020",
      "compound_name": "compound 13 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.75,
      "preparation_id": "PREP:COLLIE2025_13",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0027",
      "compound_name": "compound 13 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 1.52,
      "preparation_id": "PREP:COLLIE2025_13",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0015",
      "compound_name": "compound 5 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.16,
      "preparation_id": "PREP:COLLIE2025_5",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0022",
      "compound_name": "compound 5 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.92,
      "preparation_id": "PREP:COLLIE2025_5",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0016",
      "compound_name": "compound 6 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.71,
      "preparation_id": "PREP:COLLIE2025_6",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0023",
      "compound_name": "compound 6 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 5.83,
      "preparation_id": "PREP:COLLIE2025_6",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0017",
      "compound_name": "compound 7 (Collie 2025)",
      "assay_construct_start": 208,
      "assay_construct_end": 368,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.15,
      "preparation_id": "PREP:COLLIE2025_7",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    },
    {
      "assay_record_id": "PWWP:ASSAY:0024",
      "compound_name": "compound 7 (Collie 2025)",
      "assay_construct_start": 211,
      "assay_construct_end": 350,
      "assay_type": "SPR Kd",
      "value_operator": "=",
      "value_uM": 0.76,
      "preparation_id": "PREP:COLLIE2025_7",
      "source_id": "S05",
      "reference_id": "PMID:40959233"
    }
  ]
}