{ "version": { "version": "phase5-1.0.0", "date": "2026-10-26", "frozen_database_sha256": "0c53107a39e222b48611302b21fda5fb4ed50b190b6b39d41423ccc5ca5958f6", "chemical_identities": 148, "profiles": 163, "relevant_profiles": 132, "preparations": 30, "observations": 80, "frozen_observations": 46, "new_observations": 34, "bioactivity_only_profiles": 21, "exact_PWWP_structural_profiles": 130, "verified_depictions": 139, "reconciled_duplicate_rows": 0, "candidate_records": 150, "curated_scope": "Documented targeted snapshot; not an exhaustive inventory of all literature compounds. Coordinate proximity and assay measurements are independent evidence dimensions." }, "filters": { "q": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "protein": "", "domain": "", "bound": "", "pdb": "", "identity": "", "role": "", "method": "", "endpoint": "", "relation": "", "potency_min": "", "potency_max": "", "source": "", "year": "", "organism": "", "construct": "", "status": "", "missing": "", "scope": "all_components", "view": "gallery", "sort": "" }, "compounds": [ { "aliases": [ "UNC8153" ], "assay_count": 3, "associated_pdb_ids": [], "bound_structure_count": 0, "category": "Bioactivity only", "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "classifications": [], "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "curation_version": "phase5-1.0.0", "depiction": { "calculated_HBA": 6, "calculated_HBD": 4, "calculated_TPSA": 142.86, "calculated_formula": "C33H37N5O5", "calculated_logP": 4.3235, "calculated_molecular_weight": 583.689, "computed_inchikey": "MDIKJIFCQAJLPD-UHFFFAOYSA-N", "descriptor_scope": "RDKit calculation for the source identity; not an experimental measurement", "files": { "dark": "84e76b36f3023386133c-dark.svg", "light": "84e76b36f3023386133c-light.svg" }, "rdkit_version": "2025.09.3", "status": "verified_smiles_full_inchikey_match" }, "development_status": "Not independently curated", "domain_ids": [ "UP:O96028:PWWP1" ], "entity_kind": "chemical_identity", "genes": [ "NSD2" ], "has_bioactivity_only": true, "has_source_conflict": false, "identity": { "aliases": [], "bound_pose": false, "canonical_smiles": "C1CC1N(CC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C(=O)NCCCCCCN)C(=O)C4=CC5=C(C=C4)NC(=O)CO5", "ccd_ids": [], "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "clinical_status": "not independently assessed", "curation_version": "phase5-1.0.0", "external_identifiers": { "PubChem CID": "168893163" }, "identity_status": "resolved_reference_identity", "identity_verification": "PubChem full neutral-parent identity compared with primary Nie2024 Table1 chemical drawing; preparation salt form retained as unresolved", "inchi": "InChI=1S/C33H37N5O5/c34-17-3-1-2-4-18-35-31(40)23-9-12-26(13-10-23)36-32(41)24-7-5-22(6-8-24)20-38(27-14-15-27)33(42)25-11-16-28-29(19-25)43-21-30(39)37-28/h5-13,16,19,27H,1-4,14-15,17-18,20-21,34H2,(H,35,40)(H,36,41)(H,37,39)", "inchikey": "MDIKJIFCQAJLPD-UHFFFAOYSA-N", "isomeric_smiles": "C1CC1N(CC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C(=O)NCCCCCCN)C(=O)C4=CC5=C(C=C4)NC(=O)CO5", "molecular_formula": "C33H37N5O5", "molecular_weight": "583.7", "name": "UNC8153", "primary_name": "UNC8153", "pubchem_cid": "168893163", "retrieval_date": "2026-10-26", "smiles": "C1CC1N(CC2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C(=O)NCCCCCCN)C(=O)C4=CC5=C(C=C4)NC(=O)CO5", "source_url": "https://pubchem.ncbi.nlm.nih.gov/compound/168893163", "source_urls": [ "https://pubchem.ncbi.nlm.nih.gov/compound/168893163" ], "version": "phase5.chemical_curation.1.1.0" }, "identity_note": "Neutral parent/reference identity shown separately from the experimentally assayed preparation; salt, solvent and lot composition not independently established.", "identity_resolved": true, "is_control": false, "is_probe": false, "measured_observation_count": 3, "name": "UNC8153", "negative_count": 0, "observation_ids": [ "PWWP5:ASSAY:0009", "PWWP5:ASSAY:0010", "PWWP5:ASSAY:0011" ], "pdb_structure_count": 0, "preparation_count": 1, "preparation_ids": [ "PREP:UNC8153" ], "protein_ids": [ "UP:O96028" ], "relationships": [ { "direction": "inverse", "object_id": "PREP:UNC8587", "object_preparation_id": "PREP:UNC8153", "original_object_id": "PREP:UNC8153", "original_subject_id": "PREP:UNC8587", "predicate": "negative_control_for", "relationship": "has negative control for", "relationship_id": "P5:REL:UNC8587", "retrieval_date": "2026-10-26", "scope": "matched degradation-study negative control", "source_id": "P5:S:HANLEY2023", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "subject_id": "PREP:UNC8587", "subject_preparation_id": "PREP:UNC8587", "version": "phase5.chemical_curation.1.1.0" }, { "direction": "inverse", "object_id": "PREP:UNC7753", "object_preparation_id": "PREP:UNC8153", "original_object_id": "PREP:UNC8153", "original_subject_id": "PREP:UNC7753", "predicate": "reported_cellular_precursor_of", "relationship": "has reported cellular precursor of", "relationship_id": "P5:REL:UNC7753", "retrieval_date": "2026-10-26", "scope": "Source reports cellular proteolysis; not an interchangeable chemical identity", "source_id": "P5:S:HANLEY2023", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "subject_id": "PREP:UNC7753", "subject_preparation_id": "PREP:UNC7753", "version": "phase5.chemical_curation.1.1.0" } ], "relevant": true, "search_text": "unc8153 inchikey:mdikjifcqajlpd-uhfffaoysa-n unc8153 nsd2 up:o96028:pwwp1 {\"aliases\":[],\"bound_pose\":false,\"canonical_smiles\":\"c1cc1n(cc2=cc=c(c=c2)c(=o)nc3=cc=c(c=c3)c(=o)nccccccn)c(=o)c4=cc5=c(c=c4)nc(=o)co5\",\"ccd_ids\":[],\"chemical_id\":\"inchikey:mdikjifcqajlpd-uhfffaoysa-n\",\"clinical_status\":\"not independently assessed\",\"curation_version\":\"phase5-1.0.0\",\"external_identifiers\":{\"pubchem cid\":\"168893163\"},\"identity_status\":\"resolved_reference_identity\",\"identity_verification\":\"pubchem full neutral-parent identity compared with primary nie2024 table1 chemical drawing; preparation salt form retained as unresolved\",\"inchi\":\"inchi=1s/c33h37n5o5/c34-17-3-1-2-4-18-35-31(40)23-9-12-26(13-10-23)36-32(41)24-7-5-22(6-8-24)20-38(27-14-15-27)33(42)25-11-16-28-29(19-25)43-21-30(39)37-28/h5-13,16,19,27h,1-4,14-15,17-18,20-21,34h2,(h,35,40)(h,36,41)(h,37,39)\",\"inchikey\":\"mdikjifcqajlpd-uhfffaoysa-n\",\"isomeric_smiles\":\"c1cc1n(cc2=cc=c(c=c2)c(=o)nc3=cc=c(c=c3)c(=o)nccccccn)c(=o)c4=cc5=c(c=c4)nc(=o)co5\",\"molecular_formula\":\"c33h37n5o5\",\"molecular_weight\":\"583.7\",\"name\":\"unc8153\",\"primary_name\":\"unc8153\",\"pubchem_cid\":\"168893163\",\"retrieval_date\":\"2026-10-26\",\"smiles\":\"c1cc1n(cc2=cc=c(c=c2)c(=o)nc3=cc=c(c=c3)c(=o)nccccccn)c(=o)c4=cc5=c(c=c4)nc(=o)co5\",\"source_url\":\"https://pubchem.ncbi.nlm.nih.gov/compound/168893163\",\"source_urls\":[\"https://pubchem.ncbi.nlm.nih.gov/compound/168893163\"],\"version\":\"phase5.chemical_curation.1.1.0\"} pmid:36976643 2023 https://pmc.ncbi.nlm.nih.gov/articles/pmc10116495/ pmid:36976643 2023 https://pmc.ncbi.nlm.nih.gov/articles/pmc10116495/ pmid:36976643 2023 https://pmc.ncbi.nlm.nih.gov/articles/pmc10116495/", "source_urls": [ "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "https://pubchem.ncbi.nlm.nih.gov/compound/168893163" ], "verification_pending": false, "context_observations": [ { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "curation_version": "phase5-1.0.0", "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "SPR", "normalized_exact_uM": 0.024, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "bef834f30c55d8d859e4c0bfb28b5fe5f0d30c9888ca4f578d7276e92b5b2a5f", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "domain_specific", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0010", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "curation_version": "phase5-1.0.0", "domain": null, "domain_id": null, "endpoint": "DC50", "evidence_class": "cellular_protein_degradation", "evidence_location": "Results; Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "In-cell western degradation", "normalized_exact_uM": 0.35, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "21b6b2ff4b1f4753a13fb67dd66945de9c7cbcb5477902063ea083e9b10c9404", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0010", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "domain": null, "domain_id": null, "endpoint": "DC50", "evidence_class": "cellular_protein_degradation", "evidence_location": "Results; Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "0.13", "source_reported_units": "µM", "source_reported_value": "0.35", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 0.13, "uncertainty_type": null, "uncertainty_uM": 0.13, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:DC50", "units": "µM", "value": 0.35, "value_operator": "=", "value_uM": 0.35, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "0.13", "source_reported_units": "µM", "source_reported_value": "0.35", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "protein_level", "uncertainty": 0.13, "uncertainty_type": null, "uncertainty_uM": 0.13, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:DC50", "units": "µM", "value": 0.35, "value_operator": "=", "value_uM": 0.35, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0011", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "curation_version": "phase5-1.0.0", "domain": null, "domain_id": null, "endpoint": "Dmax", "evidence_class": "cellular_protein_degradation", "evidence_location": "Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "In-cell western degradation", "normalized_exact_uM": null, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "a6788189aec4b4366f6ead2f305355169751dad29a1ae3bff312736c031d352d", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0011", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "domain": null, "domain_id": null, "endpoint": "Dmax", "evidence_class": "cellular_protein_degradation", "evidence_location": "Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "1", "source_reported_units": "percent", "source_reported_value": "79", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 1, "uncertainty_type": null, "uncertainty_uM": null, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:Dmax", "units": "percent", "value": 79, "value_operator": "=", "value_uM": null, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "1", "source_reported_units": "percent", "source_reported_value": "79", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "protein_level", "uncertainty": 1, "uncertainty_type": null, "uncertainty_uM": null, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:Dmax", "units": "percent", "value": 79, "value_operator": "=", "value_uM": null, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" } ], "context_structures": [], "context_assay_count": 3, "context_measured_count": 3, "context_bound_count": 0, "context_pdb_count": 0, "context_negative_count": 0, "context_is_probe": false, "context_bioactivity_only": true, "context_kind": "Bioactivity only", "science": { "studied_compound": true, "measured_count": 3, "structural_research_ligand": false, "research_pdb_count": 0, "other_component": false, "component_site_count": 0, "verification_queue": false, "positive_direct_binder": true, "reported_probe": false, "reported_control": false, "cellular_activity": false, "protein_degradation": true, "bioactivity_only": true, "research_site_count": 0, "unknown_site_count": 0, "annotation_roles": [ "studied" ] }, "science_label": "Studied · no deposited PWWP research ligand", "science_profile": { "annotation_roles": [ "studied" ], "cellular_activity": false, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "entity_kind": "chemical_identity", "identity_resolved": true, "measured_observation_count": 3, "name": "UNC8153", "other_pdb_component": false, "other_site_count": 0, "positive_direct_binder": true, "primary_view": "studied", "protein_degradation": true, "reported_control": false, "reported_probe": false, "rule": "Independent source observations + per-site coordinate role, not universal pharmacology", "source_observation_ids": [ "PWWP5:ASSAY:0010", "PWWP5:ASSAY:0011", "PWWP5:ASSAY:0009" ], "source_site_ids": [], "structural_research_ligand": false, "structural_research_site_count": 0, "studied_compound": true, "total_observation_count": 3, "uncertain_site_count": 0, "uncertainty": "Classification is evidence- and experiment-scoped; missing assays do not prove nonbinding.", "verification_queue": false, "verification_status": "source_scoped_mixed" }, "science_site_roles": {}, "science_assay_roles": { "PWWP5:ASSAY:0009": { "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_type": "direct_binding", "explicitly_negative": false, "measured": true, "method": "SPR", "molecular_entity_type": "small_molecule_preparation", "observation_id": "PWWP5:ASSAY:0009", "operator": "=", "positive_direct_binder": true, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "reported_cellular": false, "reported_control": false, "reported_probe": false, "rule": "Phase5 source-curated evidence_class, material, target_scope, source role; no inferred affinities", "source_id": "P5:S:HANLEY2023", "source_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "source_role": "reported_degrader", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "studied_compound": true, "target_scope": "domain_specific", "target_variant": null, "units": "nM", "value": 24, "verification_status": "primary_source_verified" }, "PWWP5:ASSAY:0010": { "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "domain_id": null, "endpoint": "DC50", "evidence_type": "protein_degradation", "explicitly_negative": false, "measured": true, "method": "In-cell western degradation", "molecular_entity_type": "small_molecule_preparation", "observation_id": "PWWP5:ASSAY:0010", "operator": "=", "positive_direct_binder": false, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "reported_cellular": true, "reported_control": false, "reported_probe": false, "rule": "Phase5 source-curated evidence_class, material, target_scope, source role; no inferred affinities", "source_id": "P5:S:HANLEY2023", "source_location": "Results; Figure 3A; reused-data row Nie 2024 Table 1", "source_role": "reported_degrader", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "studied_compound": true, "target_scope": "protein_level", "target_variant": null, "units": "µM", "value": 0.35, "verification_status": "primary_source_verified" }, "PWWP5:ASSAY:0011": { "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "domain_id": null, "endpoint": "Dmax", "evidence_type": "protein_degradation", "explicitly_negative": false, "measured": true, "method": "In-cell western degradation", "molecular_entity_type": "small_molecule_preparation", "observation_id": "PWWP5:ASSAY:0011", "operator": "=", "positive_direct_binder": false, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "reported_cellular": true, "reported_control": false, "reported_probe": false, "rule": "Phase5 source-curated evidence_class, material, target_scope, source role; no inferred affinities", "source_id": "P5:S:HANLEY2023", "source_location": "Figure 3A; reused-data row Nie 2024 Table 1", "source_role": "reported_degrader", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "studied_compound": true, "target_scope": "protein_level", "target_variant": null, "units": "percent", "value": 79, "verification_status": "primary_source_verified" } }, "example": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "curation_version": "phase5-1.0.0", "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "SPR", "normalized_exact_uM": 0.024, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "bef834f30c55d8d859e4c0bfb28b5fe5f0d30c9888ca4f578d7276e92b5b2a5f", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "domain_specific", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "matched_observations": [ { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "curation_version": "phase5-1.0.0", "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "SPR", "normalized_exact_uM": 0.024, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "bef834f30c55d8d859e4c0bfb28b5fe5f0d30c9888ca4f578d7276e92b5b2a5f", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "purified_domain", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0009", "assay_type": "SPR Kd", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": {}, "domain": "PWWP1", "domain_id": "UP:O96028:PWWP1", "endpoint": "Kd", "evidence_class": "direct_binding_affinity", "evidence_location": "Figure 3A; numeric value visually verified in asterisk-marked original-data row of Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original value and uncertainty preserved from later primary-table reprint; original Figure 3 numeric image not separately opened. Original experiment replicate/statistic assignment and construct remain uncurated; this is not a second 2024 experiment.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "7", "source_reported_units": "nM", "source_reported_value": "24", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "domain_specific", "uncertainty": 7, "uncertainty_type": null, "uncertainty_uM": 0.007, "underlying_measurement_id": "HANLEY2023:UNC8153:SPR", "units": "nM", "value": 24, "value_operator": "=", "value_uM": 0.024, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0010", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "curation_version": "phase5-1.0.0", "domain": null, "domain_id": null, "endpoint": "DC50", "evidence_class": "cellular_protein_degradation", "evidence_location": "Results; Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "In-cell western degradation", "normalized_exact_uM": 0.35, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "21b6b2ff4b1f4753a13fb67dd66945de9c7cbcb5477902063ea083e9b10c9404", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0010", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "domain": null, "domain_id": null, "endpoint": "DC50", "evidence_class": "cellular_protein_degradation", "evidence_location": "Results; Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "0.13", "source_reported_units": "µM", "source_reported_value": "0.35", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 0.13, "uncertainty_type": null, "uncertainty_uM": 0.13, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:DC50", "units": "µM", "value": 0.35, "value_operator": "=", "value_uM": 0.35, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "0.13", "source_reported_units": "µM", "source_reported_value": "0.35", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "protein_level", "uncertainty": 0.13, "uncertainty_type": null, "uncertainty_uM": 0.13, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:DC50", "units": "µM", "value": 0.35, "value_operator": "=", "value_uM": 0.35, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0011", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "curation_version": "phase5-1.0.0", "domain": null, "domain_id": null, "endpoint": "Dmax", "evidence_class": "cellular_protein_degradation", "evidence_location": "Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_measured": true, "is_negative": false, "method": "In-cell western degradation", "normalized_exact_uM": null, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "organism": "Homo sapiens", "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_database": "Primary literature (Phase 5)", "source_id": "P5:S:HANLEY2023", "source_measurement_key": "a6788189aec4b4366f6ead2f305355169751dad29a1ae3bff312736c031d352d", "source_original": { "additional_source_urls": [ "https://www.nature.com/articles/s41589-024-01660-y/tables/1" ], "assay_construct_end": null, "assay_construct_start": null, "assay_context": "cellular_full_protein", "assay_organism": "Homo sapiens", "assay_record_id": "PWWP5:ASSAY:0011", "assay_type": "In-cell western degradation", "assay_value_transferred_to_modeled_stereoisomers": false, "ccd_id": null, "chemical_id": "INCHIKEY:MDIKJIFCQAJLPD-UHFFFAOYSA-N", "compound_name": "UNC8153", "conditions": { "cell_line": "U2OS", "duration_hours": 24, "readout": "total NSD2 including major long/short isoforms" }, "domain": null, "domain_id": null, "endpoint": "Dmax", "evidence_class": "cellular_protein_degradation", "evidence_location": "Figure 3A; reused-data row Nie 2024 Table 1", "evidence_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10116495/", "gene": "NSD2", "inclusion_rationale": "Primary source explicitly identifies this preparation, target context and observation.", "is_negative": false, "numeric_transcription_status": "source_preserved", "numeric_value_inferred_from_structure": false, "pdb_id": null, "preparation_id": "PREP:UNC8153", "protein_id": "UP:O96028", "publication_year": 2023, "reference_id": "PMID:36976643", "remaining_uncertainty": "Original numerical values and uncertainties are corroborated by the explicitly reused row of Nie 2024 Table 1. Original Figure 3 has multiple statistic/replicate annotations; its numeric panel was not independently opened, so the relevant annotation is left uncurated. No independent 2024 replicate is counted.", "replicates": null, "retrieval_date": "2026-10-26", "role": "reported_degrader", "source_id": "P5:S:HANLEY2023", "source_reported_uncertainty": "1", "source_reported_units": "percent", "source_reported_value": "79", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "uncertainty": 1, "uncertainty_type": null, "uncertainty_uM": null, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:Dmax", "units": "percent", "value": 79, "value_operator": "=", "value_uM": null, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" }, "source_reported_uncertainty": "1", "source_reported_units": "percent", "source_reported_value": "79", "source_verification_scope": "NCBI BioC primary full text and captions; exact UNC8153 values additionally checked in reused original-data row of Nie 2024 Table 1", "target_scope": "protein_level", "uncertainty": 1, "uncertainty_type": null, "uncertainty_uM": null, "underlying_measurement_id": "HANLEY2023:UNC8153:ICW:Dmax", "units": "percent", "value": 79, "value_operator": "=", "value_uM": null, "verification_level": "primary_source_verified", "version": "phase5.chemical_curation.1.1.0" } ], "matched_assay_count": 3 } ] }