{
  "version": {
    "version": "phase5-1.0.0",
    "date": "2026-10-26",
    "frozen_database_sha256": "0c53107a39e222b48611302b21fda5fb4ed50b190b6b39d41423ccc5ca5958f6",
    "chemical_identities": 148,
    "profiles": 163,
    "relevant_profiles": 132,
    "preparations": 30,
    "observations": 80,
    "frozen_observations": 46,
    "new_observations": 34,
    "bioactivity_only_profiles": 21,
    "exact_PWWP_structural_profiles": 130,
    "verified_depictions": 139,
    "reconciled_duplicate_rows": 0,
    "candidate_records": 150,
    "curated_scope": "Documented targeted snapshot; not an exhaustive inventory of all literature compounds. Coordinate proximity and assay measurements are independent evidence dimensions."
  },
  "filters": {
    "q": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
    "protein": "",
    "domain": "",
    "bound": "",
    "pdb": "",
    "identity": "",
    "role": "",
    "method": "",
    "endpoint": "",
    "relation": "",
    "potency_min": "",
    "potency_max": "",
    "source": "",
    "year": "",
    "organism": "",
    "construct": "",
    "status": "",
    "missing": "",
    "scope": "all_components",
    "view": "gallery",
    "sort": ""
  },
  "compounds": [
    {
      "aliases": [
        "1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione"
      ],
      "assay_count": 0,
      "associated_pdb_ids": [
        "9Y61"
      ],
      "bound_structure_count": 1,
      "category": "Structure-supported identity",
      "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
      "classifications": [],
      "compound_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
      "curation_version": "phase5-1.0.0",
      "depiction": {
        "calculated_HBA": 7,
        "calculated_HBD": 2,
        "calculated_TPSA": 114.53,
        "calculated_formula": "C39H49Cl2FN6O5",
        "calculated_logP": 5.5638,
        "calculated_molecular_weight": 771.762,
        "computed_inchikey": "LDKYLKMCPUFNTL-PJTQZDKOSA-N",
        "descriptor_scope": "RDKit calculation for the source identity; not an experimental measurement",
        "files": {
          "dark": "b73cfe57eabe372da74e-dark.svg",
          "light": "b73cfe57eabe372da74e-light.svg"
        },
        "rdkit_version": "2025.09.3",
        "status": "verified_smiles_full_inchikey_match"
      },
      "development_status": "Not independently curated",
      "domain_ids": [
        "UP:O96028:PWWP1"
      ],
      "entity_kind": "chemical_identity",
      "genes": [
        "NSD2"
      ],
      "has_bioactivity_only": false,
      "has_source_conflict": false,
      "identity": {
        "aliases": [
          "1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione"
        ],
        "ccd_ids": [
          "A1CSQ"
        ],
        "ccd_names": "[\"1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione\"]",
        "ccd_types": "[\"non-polymer\"]",
        "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
        "connectivity_block": "LDKYLKMCPUFNTL",
        "curated_source_sha256": null,
        "curation_version": "frozen-v1.2",
        "external_identifiers": {},
        "formal_charge_by_ccd": "{\"A1CSQ\": 0}",
        "formulae": "[\"C39 H49 Cl2 F N6 O5\"]",
        "geometry_note": "CCD ideal SDF is a reference chemical geometry, not a deposited bound pose.",
        "identity_status": "complete_deposited_InChIKey",
        "inchikey": "LDKYLKMCPUFNTL-PJTQZDKOSA-N",
        "inventory_origin": "v1_CCD_inventory",
        "isomeric_smiles": "Cc1ccc(cc1N2CCC(=O)NC2=O)C(=O)N3CCC4(CCC(CC4)CN5CCN(CC5)CC[C@@H]6[C@@H](OCC(=O)N6)c7cc(c(c(c7)Cl)F)Cl)CC3",
        "primary_name": "1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione",
        "retrieval_date": "2026-10-24",
        "smiles_stereo_by_ccd": "{\"A1CSQ\": \"Cc1ccc(cc1N2CCC(=O)NC2=O)C(=O)N3CCC4(CCC(CC4)CN5CCN(CC5)CC[C@@H]6[C@@H](OCC(=O)N6)c7cc(c(c(c7)Cl)F)Cl)CC3\"}",
        "source_metadata_sha256": "{\"A1CSQ\": \"b75d4250ea6f12583bb5c9f1ae38ef5843b98989d47fc8726d05e1d5c211c869\"}",
        "source_urls": [
          "https://www.rcsb.org/ligand/A1CSQ"
        ]
      },
      "identity_note": "complete_deposited_InChIKey",
      "identity_resolved": true,
      "is_control": false,
      "is_probe": false,
      "measured_observation_count": 0,
      "name": "1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione",
      "negative_count": 0,
      "observation_ids": [],
      "pdb_structure_count": 1,
      "preparation_count": 0,
      "preparation_ids": [],
      "protein_ids": [
        "UP:O96028"
      ],
      "relationships": [],
      "relevant": true,
      "search_text": "1-(5-{9-[(4-{2-[(2s,3r)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione inchikey:ldkylkmcpufntl-pjtqzdkosa-n 1-(5-{9-[(4-{2-[(2s,3r)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione nsd2 up:o96028:pwwp1 9y61 {\"aliases\":[\"1-(5-{9-[(4-{2-[(2s,3r)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione\"],\"ccd_ids\":[\"a1csq\"],\"ccd_names\":\"[\\\"1-(5-{9-[(4-{2-[(2s,3r)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione\\\"]\",\"ccd_types\":\"[\\\"non-polymer\\\"]\",\"chemical_id\":\"inchikey:ldkylkmcpufntl-pjtqzdkosa-n\",\"connectivity_block\":\"ldkylkmcpufntl\",\"curated_source_sha256\":null,\"curation_version\":\"frozen-v1.2\",\"external_identifiers\":{},\"formal_charge_by_ccd\":\"{\\\"a1csq\\\": 0}\",\"formulae\":\"[\\\"c39 h49 cl2 f n6 o5\\\"]\",\"geometry_note\":\"ccd ideal sdf is a reference chemical geometry, not a deposited bound pose.\",\"identity_status\":\"complete_deposited_inchikey\",\"inchikey\":\"ldkylkmcpufntl-pjtqzdkosa-n\",\"inventory_origin\":\"v1_ccd_inventory\",\"isomeric_smiles\":\"cc1ccc(cc1n2ccc(=o)nc2=o)c(=o)n3ccc4(ccc(cc4)cn5ccn(cc5)cc[c@@h]6[c@@h](occ(=o)n6)c7cc(c(c(c7)cl)f)cl)cc3\",\"primary_name\":\"1-(5-{9-[(4-{2-[(2s,3r)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione\",\"retrieval_date\":\"2026-10-24\",\"smiles_stereo_by_ccd\":\"{\\\"a1csq\\\": \\\"cc1ccc(cc1n2ccc(=o)nc2=o)c(=o)n3ccc4(ccc(cc4)cn5ccn(cc5)cc[c@@h]6[c@@h](occ(=o)n6)c7cc(c(c(c7)cl)f)cl)cc3\\\"}\",\"source_metadata_sha256\":\"{\\\"a1csq\\\": \\\"b75d4250ea6f12583bb5c9f1ae38ef5843b98989d47fc8726d05e1d5c211c869\\\"}\",\"source_urls\":[\"https://www.rcsb.org/ligand/a1csq\"]}",
      "source_urls": [
        "https://www.rcsb.org/ligand/A1CSQ"
      ],
      "verification_pending": false,
      "context_observations": [],
      "context_structures": [
        {
          "Pfam_contacts_5A": "[{\"auth_asym_id\": \"A\", \"auth_seq_id\": \"230\", \"component\": \"VAL\", \"entity_position\": 30, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.5034, \"uniprot_position\": 230}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"233\", \"component\": \"TYR\", \"entity_position\": 33, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.0811, \"uniprot_position\": 233}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"234\", \"component\": \"PRO\", \"entity_position\": 34, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.7823, \"uniprot_position\": 234}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"236\", \"component\": \"TRP\", \"entity_position\": 36, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.3744, \"uniprot_position\": 236}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"266\", \"component\": \"PHE\", \"entity_position\": 66, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.3411, \"uniprot_position\": 266}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"267\", \"component\": \"PHE\", \"entity_position\": 67, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6551, \"uniprot_position\": 267}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"268\", \"component\": \"GLY\", \"entity_position\": 68, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6256, \"uniprot_position\": 268}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"269\", \"component\": \"ASP\", \"entity_position\": 69, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6387, \"uniprot_position\": 269}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"270\", \"component\": \"ALA\", \"entity_position\": 70, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.2427, \"uniprot_position\": 270}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"272\", \"component\": \"GLU\", \"entity_position\": 72, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.223, \"uniprot_position\": 272}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"274\", \"component\": \"ALA\", \"entity_position\": 74, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 4.9239, \"uniprot_position\": 274}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"321\", \"component\": \"GLN\", \"entity_position\": 121, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 2.8979, \"uniprot_position\": 321}]",
          "biochemical_activity_inferred": 0,
          "ccd_id": "A1CSQ",
          "chain_contacts_5A": "[{\"auth_asym_id\": \"A\", \"auth_seq_id\": \"230\", \"component\": \"VAL\", \"entity_position\": 30, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.5034, \"uniprot_position\": 230}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"233\", \"component\": \"TYR\", \"entity_position\": 33, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.0811, \"uniprot_position\": 233}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"234\", \"component\": \"PRO\", \"entity_position\": 34, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.7823, \"uniprot_position\": 234}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"236\", \"component\": \"TRP\", \"entity_position\": 36, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.3744, \"uniprot_position\": 236}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"266\", \"component\": \"PHE\", \"entity_position\": 66, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.3411, \"uniprot_position\": 266}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"267\", \"component\": \"PHE\", \"entity_position\": 67, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6551, \"uniprot_position\": 267}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"268\", \"component\": \"GLY\", \"entity_position\": 68, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6256, \"uniprot_position\": 268}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"269\", \"component\": \"ASP\", \"entity_position\": 69, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.6387, \"uniprot_position\": 269}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"270\", \"component\": \"ALA\", \"entity_position\": 70, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.2427, \"uniprot_position\": 270}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"272\", \"component\": \"GLU\", \"entity_position\": 72, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 3.223, \"uniprot_position\": 272}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"274\", \"component\": \"ALA\", \"entity_position\": 74, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 4.9239, \"uniprot_position\": 274}, {\"auth_asym_id\": \"A\", \"auth_seq_id\": \"321\", \"component\": \"GLN\", \"entity_position\": 121, \"label_asym_id\": \"A\", \"minimum_distance_angstrom\": 2.8979, \"uniprot_position\": 321}]",
          "chain_id": "PDB:9Y61:CHAIN:A:UP:O96028",
          "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
          "contact_class": "native_annotation_core_contact",
          "contact_distance_rank": 1,
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          "covalent_connection_ids": "[]",
          "cutoff_angstrom": 5.0,
          "domain_id": "UP:O96028:PWWP1",
          "exact_pwwp_contact": true,
          "gene": "NSD2",
          "geometry_scope": "first deposited model; asymmetric unit; heavy atoms with occupancy >0; alternate locations retained; no symmetry expansion",
          "instance": {
            "alternate_locations": "[]",
            "auth_asym_ids": "[\"A\"]",
            "auth_seq_id": "4000",
            "ccd_id": "A1CSQ",
            "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
            "component_context": "nonpolymer_component",
            "contacted_polymer_partners": "[{\"description\": \"Histone-lysine N-methyltransferase NSD2\", \"entity_id\": \"1\", \"is_PWWP_family_protein\": true, \"label_asym_id\": \"A\", \"sequence_length\": 174, \"uniprot_ids\": [\"O96028\"]}, {\"description\": \"Protein cereblon\", \"entity_id\": \"2\", \"is_PWWP_family_protein\": false, \"label_asym_id\": \"B\", \"sequence_length\": 467, \"uniprot_ids\": [\"Q96SW2\"]}]",
            "covalent_connection_ids": "[]",
            "heavy_atom_row_count": 53,
            "ideal_CCD_SDF_is_source_pose": 0,
            "label_asym_id": "C",
            "label_seq_id": null,
            "ligand_instance_id": "PDB:9Y61:LIG:C:A1CSQ:4000:.",
            "nearest_polypeptide_distance_angstrom": 2.8979,
            "nearest_polypeptide_label_asym_id": "A",
            "occupancy_max": 1.0,
            "occupancy_min": 1.0,
            "pdb_id": "9Y61",
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{\"auth_asym_id\": \"B\", \"auth_seq_id\": \"357\", \"component\": \"HIS\", \"entity_position\": 382, \"label_asym_id\": \"B\", \"minimum_distance_angstrom\": 3.4426, \"uniprot_position\": null}, {\"auth_asym_id\": \"B\", \"auth_seq_id\": \"377\", \"component\": \"GLU\", \"entity_position\": 402, \"label_asym_id\": \"B\", \"minimum_distance_angstrom\": 4.1869, \"uniprot_position\": null}, {\"auth_asym_id\": \"B\", \"auth_seq_id\": \"378\", \"component\": \"HIS\", \"entity_position\": 403, \"label_asym_id\": \"B\", \"minimum_distance_angstrom\": 3.11, \"uniprot_position\": null}, {\"auth_asym_id\": \"B\", \"auth_seq_id\": \"379\", \"component\": \"SER\", \"entity_position\": 404, \"label_asym_id\": \"B\", \"minimum_distance_angstrom\": 3.8792, \"uniprot_position\": null}, {\"auth_asym_id\": \"B\", \"auth_seq_id\": \"380\", \"component\": \"TRP\", \"entity_position\": 405, \"label_asym_id\": \"B\", \"minimum_distance_angstrom\": 3.077, \"uniprot_position\": null}, {\"auth_asym_id\": 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            "pose_kind": "deposited_source_coordinates",
            "reference_model": "1",
            "source_coordinate_file": "Structures/NSD2__HUMAN__O96028/Complexes/9Y61/original.cif",
            "source_coordinate_sha256": "5205373a6fdf371bbd5e46ee7386aa47865eefdad8f6e3ea8462b6d0ada2bf94",
            "unique_heavy_atom_names": 53
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          "ligand_instance_id": "PDB:9Y61:LIG:C:A1CSQ:4000:.",
          "ligand_label_asym_id": "C",
          "minimum_Pfam_distance_angstrom": 2.8979,
          "minimum_chain_distance_angstrom": 2.8979,
          "minimum_core_distance_angstrom": 3.0811,
          "multiple_contacting_mapped_chains": 0,
          "pdb_id": "9Y61",
          "protein_id": "UP:O96028",
          "protein_label_asym_id": "A",
          "rank_interpretation": "Distance rank among mapped chains only; crystal packing and biological site assignment require separate review.",
          "role": "experimentally studied degrader",
          "role_category": "functional",
          "site_id": "PDB:9Y61:LIG:C:A1CSQ:4000:.:SITE:UP:O96028:PWWP1:A",
          "source_coordinate_sha256": "5205373a6fdf371bbd5e46ee7386aa47865eefdad8f6e3ea8462b6d0ada2bf94"
        }
      ],
      "context_assay_count": 0,
      "context_measured_count": 0,
      "context_bound_count": 1,
      "context_pdb_count": 1,
      "context_negative_count": 0,
      "context_is_probe": false,
      "context_bioactivity_only": false,
      "context_kind": "PWWP-proximal structure",
      "science": {
        "studied_compound": false,
        "measured_count": 0,
        "structural_research_ligand": true,
        "research_pdb_count": 1,
        "other_component": false,
        "component_site_count": 0,
        "verification_queue": false,
        "positive_direct_binder": false,
        "reported_probe": false,
        "reported_control": false,
        "cellular_activity": false,
        "protein_degradation": false,
        "bioactivity_only": false,
        "research_site_count": 1,
        "unknown_site_count": 0,
        "annotation_roles": [
          "structural"
        ]
      },
      "science_label": "Deposited research ligand · no curated assay",
      "science_profile": {
        "annotation_roles": [
          "structural"
        ],
        "cellular_activity": false,
        "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
        "compound_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
        "entity_kind": "chemical_identity",
        "identity_resolved": true,
        "measured_observation_count": 0,
        "name": "1-(5-{9-[(4-{2-[(2S,3R)-2-(3,5-dichloro-4-fluorophenyl)-5-oxomorpholin-3-yl]ethyl}piperazin-1-yl)methyl]-3-azaspiro[5.5]undecane-3-carbonyl}-2-methylphenyl)-1,3-diazinane-2,4-dione",
        "other_pdb_component": false,
        "other_site_count": 0,
        "positive_direct_binder": false,
        "primary_view": "structural",
        "protein_degradation": false,
        "reported_control": false,
        "reported_probe": false,
        "rule": "Independent source observations + per-site coordinate role, not universal pharmacology",
        "source_observation_ids": [],
        "source_site_ids": [
          "PDB:9Y61:LIG:C:A1CSQ:4000:.:SITE:UP:O96028:PWWP1:A"
        ],
        "structural_research_ligand": true,
        "structural_research_site_count": 1,
        "studied_compound": false,
        "total_observation_count": 0,
        "uncertain_site_count": 0,
        "uncertainty": "Classification is evidence- and experiment-scoped; missing assays do not prove nonbinding.",
        "verification_queue": false,
        "verification_status": "source_scoped_mixed"
      },
      "science_site_roles": {
        "PDB:9Y61:LIG:C:A1CSQ:4000:.:SITE:UP:O96028:PWWP1:A": {
          "ccd_url": "https://www.rcsb.org/ligand/A1CSQ",
          "chemical_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
          "compound_id": "INCHIKEY:LDKYLKMCPUFNTL-PJTQZDKOSA-N",
          "contact_class": "native_annotation_core_contact",
          "coordinate_sha256": "5205373a6fdf371bbd5e46ee7386aa47865eefdad8f6e3ea8462b6d0ada2bf94",
          "domain_id": "UP:O96028:PWWP1",
          "exact_pwwp_contact": true,
          "ligand_instance_id": "PDB:9Y61:LIG:C:A1CSQ:4000:.",
          "observed_other_component": false,
          "pdb_id": "9Y61",
          "protein_id": "UP:O96028",
          "role_code": "reported_degrader_structural_ligand",
          "role_group": "research_ligand",
          "rule": "Phase5 exact deposited site role, measured heavy-atom contacts and native-domain scope",
          "site_id": "PDB:9Y61:LIG:C:A1CSQ:4000:.:SITE:UP:O96028:PWWP1:A",
          "source_role": "experimentally studied degrader",
          "source_url": "https://www.rcsb.org/structure/9Y61",
          "structural_research_ligand": true,
          "uncertainty": "Role is source-annotated; deposited proximity alone does not establish solution binding or biological activity.",
          "verification_status": "phase5_derived_deposited_geometry"
        }
      },
      "science_assay_roles": {},
      "example": null,
      "matched_observations": [],
      "matched_assay_count": 0
    }
  ]
}