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Includes possible literature carry-forward rows; not counted as new independent experiments.", "retrieval_date": "2026-10-26", "source_database": "ChEMBL", "source_id": "P5:S:CARLINO2024", "source_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865176", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "assay_chembl_id": "CHEMBL5511298", "assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by alphascreen assay", "candidate_id": "CAND:CHEMBL:25865177", "document_chembl_id": "CHEMBL5506052", "molecule_chembl_id": "CHEMBL5200945", "original_row": { "action_type": { "action_type": "INHIBITOR", "description": "Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway", "parent_type": "NEGATIVE MODULATOR" }, "activity_comment": null, "activity_id": 25865177, "activity_properties": [], "assay_chembl_id": "CHEMBL5511298", "assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by alphascreen assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=C1COc2cc(C(=O)N(Cc3ccc(C(=O)Nc4ccncn4)cc3)C3CC3)ccc2N1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5506052", "document_journal": "J Med Chem", "document_year": 2024, "ligand_efficiency": { "bei": "15.75", "le": "0.29", "lle": "4.12", "sei": "6.15" }, "modality": null, "molecule_chembl_id": "CHEMBL5200945", "molecule_pref_name": null, "parent_molecule_chembl_id": "CHEMBL5200945", "pchembl_value": "6.98", "potential_duplicate": 1, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 4060431, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "104.0", "target_chembl_id": "CHEMBL3108645", "target_organism": "Homo sapiens", "target_pref_name": "Histone-lysine N-methyltransferase NSD2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "104.0" }, "rationale": "Activity and identity available in ChEMBL, but original primary numerical table/chemical-label attribution not fully verified. Includes possible literature carry-forward rows; not counted as new independent experiments.", "retrieval_date": "2026-10-26", "source_database": "ChEMBL", "source_id": "P5:S:CARLINO2024", "source_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865177", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "assay_chembl_id": "CHEMBL5511299", "assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by NanoBRET target engagement assay", "candidate_id": "CAND:CHEMBL:25865178", "document_chembl_id": "CHEMBL5506052", "molecule_chembl_id": "CHEMBL5200945", "original_row": { "action_type": { "action_type": "INHIBITOR", "description": "Negatively effects (inhibits) the normal functioning of the protein e.g., prevention of enzymatic reaction or activation of downstream pathway", "parent_type": "NEGATIVE MODULATOR" }, "activity_comment": null, "activity_id": 25865178, "activity_properties": [], "assay_chembl_id": "CHEMBL5511299", "assay_description": "Inhibition of NSD2 PWWP1 domain (unknown origin) by NanoBRET target engagement assay", "assay_type": "B", "assay_variant_accession": null, "assay_variant_mutation": null, "bao_endpoint": "BAO_0000190", "bao_format": "BAO_0000357", "bao_label": "single protein format", "canonical_smiles": "O=C1COc2cc(C(=O)N(Cc3ccc(C(=O)Nc4ccncn4)cc3)C3CC3)ccc2N1", "data_validity_comment": null, "data_validity_description": null, "document_chembl_id": "CHEMBL5506052", "document_journal": "J Med Chem", "document_year": 2024, "ligand_efficiency": { "bei": "20.09", "le": "0.37", "lle": "6.05", "sei": "7.85" }, "modality": null, "molecule_chembl_id": "CHEMBL5200945", "molecule_pref_name": null, "parent_molecule_chembl_id": "CHEMBL5200945", "pchembl_value": "8.91", "potential_duplicate": 0, "qudt_units": "http://www.openphacts.org/units/Nanomolar", "record_id": 4060431, "relation": "=", "src_id": 1, "standard_flag": 1, "standard_relation": "=", "standard_text_value": null, "standard_type": "IC50", "standard_units": "nM", "standard_upper_value": null, "standard_value": "1.23", "target_chembl_id": "CHEMBL3108645", "target_organism": "Homo sapiens", "target_pref_name": "Histone-lysine N-methyltransferase NSD2", "target_tax_id": "9606", "text_value": null, "toid": null, "type": "IC50", "units": "nM", "uo_units": "UO_0000065", "upper_value": null, "value": "1.23" }, "rationale": "Activity and identity available in ChEMBL, but original primary numerical table/chemical-label attribution not fully verified. Includes possible literature carry-forward rows; not counted as new independent experiments.", "retrieval_date": "2026-10-26", "source_database": "ChEMBL", "source_id": "P5:S:CARLINO2024", "source_url": "https://www.ebi.ac.uk/chembl/explore/activity/25865178", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:BINDINGDB:O96028", "rationale": "Exact accession query, no sequence similarity transfer. Returned endpoint values lack source/construct context in this API response and may represent SET/other-domain assays. No values promoted to PWWP evidence.", "retrieval_date": "2026-10-26", "row_count": 92, "source_database": "BindingDB", "source_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=O96028&response=application/json", "status": "target_level_discovery_only", "uniprot": "O96028", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:BINDINGDB:Q9BZ95", "rationale": "Exact accession query, no sequence similarity transfer. Returned endpoint values lack source/construct context in this API response and may represent SET/other-domain assays. No values promoted to PWWP evidence.", "retrieval_date": "2026-10-26", "row_count": 5, "source_database": "BindingDB", "source_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=Q9BZ95&response=application/json", "status": "target_level_discovery_only", "uniprot": "Q9BZ95", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:BINDINGDB:O75475", "rationale": "Exact accession query, no sequence similarity transfer. Returned endpoint values lack source/construct context in this API response and may represent SET/other-domain assays. No values promoted to PWWP evidence.", "retrieval_date": "2026-10-26", "row_count": 7, "source_database": "BindingDB", "source_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=O75475&response=application/json", "status": "target_level_discovery_only", "uniprot": "O75475", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:BINDINGDB:Q7Z4V5", "rationale": "Exact accession query, no sequence similarity transfer. Returned endpoint values lack source/construct context in this API response and may represent SET/other-domain assays. No values promoted to PWWP evidence.", "retrieval_date": "2026-10-26", "row_count": 0, "source_database": "BindingDB", "source_url": "https://www.bindingdb.org/rest/getLigandsByUniprot?uniprot=Q7Z4V5&response=application/json", "status": "target_level_discovery_only", "uniprot": "Q7Z4V5", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:HS13", "name": "HS13", "rationale": "Already represented as pending baseline association. Primary abstract reports Kd8.33µM, but assay-specific construct/method and full identity remain unverified; library-size conflict943/968 in publisher text versus abstract preserved.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://doi.org/10.1016/j.bmc.2026.118751", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:HRP_family_fragment_series", "name": "HRP family fragment series", "rationale": "Primary abstract and ChEMBL assay descriptions found; per-compound primary values/identity not fully verified.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://doi.org/10.1016/j.ejmech.2024.116960", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:XSY12", "name": "XSY12", "rationale": "New2026 NSD3 hydrophobic-tag degrader lead; do not promote from abstract alone.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://pubmed.ncbi.nlm.nih.gov/42503659/", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:LY-06", "name": "LY-06", "rationale": "Current NSD3 fluorescent-ligand lead identified by independent structural audit; not yet verified.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://pubmed.ncbi.nlm.nih.gov/41820229/", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:NSD2-LDD", "name": "NSD2-LDD", "rationale": "Current NSD2 degrader lead; source/construct/chemical identity verification pending.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://doi.org/10.1182/blood.2025031998", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:LIT:UNC10415667_/_UNC10088", "name": "UNC10415667 / UNC10088", "rationale": "Current structural recruitment study; pending exact assay/identity/ligand-instance reconciliation.", "retrieval_date": "2026-10-26", "source_database": "primary literature", "source_url": "https://www.nature.com/articles/s41467-026-72235-9", "status": "candidate_not_promoted", "version": "phase5.chemical_curation.1.1.0" }, { "candidate_id": "CAND:NAME:MR927", "name": "MR927", "queries": [ "\"MR927\" PWWP", "\"MR927\" inhibitor NSD2" ], "rationale": "Exact-name searches combined with PWWP/NSD2 did not recover primary evidence. Do not silently substitute MR837 or assert identity. This is a scoped search result, not proof of nonexistence.", "retrieval_date": "2026-10-26", "status": "excluded_unverified_name", "version": "phase5.chemical_curation.1.1.0" } ] }